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Enzyme Commission (EC): Other carbon--nitrogen ligases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Ligases [6] <6>(96|123) (95|112|69)
+ 1:   Forming carbon-nitrogen bonds [6.3] <5>(59|78) (58|59|38)
0:   Other carbon--nitrogen ligases [6.3.4] <24>(28|31) (27|28|19)
- 1:   5-(carboxyamino)imidazole ribonucleotide synthase [6.3.4.18](3|3) (3|2|1)
- 1:   7-cyano-7-deazaguanine synthase [6.3.4.20](1|1) (1|1|0)
- 1:   Adenylosuccinate synthase [6.3.4.4](1|1) (1|0|0)
- 1:   Argininosuccinate synthase [6.3.4.5](2|2) (2|1|0)
- 1:   Biotin carboxylase [6.3.4.14](5|5) (5|2|1)
- 1:   Biotin--[biotin carboxyl-carrier protein] ligase [6.3.4.15](4|3) (4|4|3)
- 1:   Biotin--[methylcrotonoyl-CoA-carboxylase] ligase [6.3.4.11](1|1) (1|0|0)
- 1:   Biotin--[methylmalonyl-CoA-carboxytransferase] ligase [6.3.4.9](1|1) (1|0|0)
- 1:   Biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase [6.3.4.10](1|1) (1|0|0)
- 1:   CTP synthase (glutamine hydrolyzing) [6.3.4.2](3|2) (2|3|1)
- 1:   Carbamoyl-phosphate synthase (ammonia) [6.3.4.16](5|4) (5|6|6)
- 1:   Formate--dihydrofolate ligase [6.3.4.17](0|0) (0|0|0)
- 1:   Formate--phosphoribosylaminoimidazolecarboxamide ligase [6.3.4.23](2|2) (2|1|0)
- 1:   Formate--tetrahydrofolate ligase [6.3.4.3](2|3) (2|1|0)
- 1:   Glutamate--methylamine ligase [6.3.4.12](0|0) (0|0|0)
- 1:   Imidazoleacetate--phosphoribosyldiphosphate ligase [6.3.4.8](0|0) (0|0|0)
- 1:   Nicotinate phosphoribosyltransferase [6.3.4.21](2|4) (2|1|0)
- 1:   Phosphoribosylamine--glycine ligase [6.3.4.13](6|6) (6|6|6)
- 1:   Ribose-5-phosphate--ammonia ligase [6.3.4.7](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.5.2 [6.3.4.1](0|0) (0|0|0)
- 1:   Tyramine--L-glutamate ligase [6.3.4.24](0|0) (0|0|0)
- 1:   Urea carboxylase [6.3.4.6](6|6) (6|4|2)
- 1:   tRNA(Ile)(2)-agmatinylcytidine synthase [6.3.4.22](1|0) (1|0|0)
- 1:   tRNA(Ile)-lysidine synthetase [6.3.4.19](3|4) (3|4|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Argininosuccinate synthetase, C-terminal domain0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
C-terminal domain of transcriptional repressors0Direct
Nicotinate/Quinolinate PRTase N-terminal domain-like0Direct
Single hybrid motif0Direct
Rudiment single hybrid motif0Direct
MesJ substrate recognition domain-like0Direct
Nicotinate/Quinolinate PRTase C-terminal domain-like0Direct
PheT/TilS domain0Direct
Adenine nucleotide alpha hydrolases-like0Direct
PH0987 N-terminal domain-like0.000002206Direct
Class I glutamine amidotransferase-like0.002462Inherited
SCOP hierarchy in SUPERFAMILY0.02981Inherited
Cyclophilin-like0.827Inherited
Formyltransferase1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
Methylglyoxal synthase-like1Inherited
PurM C-terminal domain-like1Inherited
"Winged helix" DNA-binding domain1Inherited
PurM N-terminal domain-like1Inherited
Carbamoyl phosphate synthetase, large subunit connection domain1Inherited
Actin-like ATPase domain1Inherited
Nucleic acid-binding proteins1Inherited
Aminoacid dehydrogenase-like, N-terminal domain1Inherited
Class II aaRS and biotin synthetases1Inherited
PreATP-grasp domain1Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain1Inherited
ClpP/crotonase1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
PurP ATP-binding domain-like0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
PurP N-terminal domain-like0Direct
Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like0Direct
MesJ substrate recognition domain-like0Direct
N-type ATP pyrophosphatases0Direct
NadC C-terminal domain-like0Direct
NadC N-terminal domain-like0Direct
Nitrogenase iron protein-like0Direct
tRNA-Ile-lysidine synthetase, TilS, C-terminal domain0Direct
PP-loop ATPase0Direct
Biotin repressor (BirA)0Direct
BC C-terminal domain-like0Direct
Monomeric nicotinate phosphoribosyltransferase C-terminal domain0Direct
Argininosuccinate synthetase, C-terminal domain0Direct
Biotin holoenzyme synthetase0Direct
PH0987 N-terminal domain-like0.000000834Direct
PH0987 C-terminal domain-like0.000002432Direct
BC ATP-binding domain-like0.00007354Direct
BC N-terminal domain-like0.0001785Direct
Class I glutamine amidotransferases (GAT)0.0001959Direct
Deoxycytidylate deaminase-like0.01227Inherited
Biotin dependent carboxylase carboxyltransferase domain0.1423Inherited
Tetrahydrofolate dehydrogenase/cyclohydrolase0.4645Inherited
CoaX-like0.9036Inherited
Carbamoyl phosphate synthetase, large subunit connection domain1Inherited
Aminoacid dehydrogenase-like, C-terminal domain1Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain1Inherited
PurM N-terminal domain-like1Inherited
PurM C-terminal domain-like1Inherited
Formyltransferase1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Adenine nucleotide alpha hydrolases-like0Direct
PheT/TilS domain0Direct
Single hybrid motif0Direct
Rudiment single hybrid motif0Direct
Nicotinate/Quinolinate PRTase C-terminal domain-like0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Argininosuccinate synthetase, C-terminal domain0Direct
MesJ substrate recognition domain-like0Direct
Nicotinate/Quinolinate PRTase N-terminal domain-like0Direct
C-terminal domain of transcriptional repressors0Direct
PH0987 N-terminal domain-like0.000001732Direct
Class I glutamine amidotransferase-like0.002054Inherited
Cyclophilin-like0.7624Inherited
Formyltransferase0.957Inherited
Nucleic acid-binding proteins1Inherited
PurM C-terminal domain-like1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain1Inherited
PurM N-terminal domain-like1Inherited
Class II aaRS and biotin synthetases1Inherited
ClpP/crotonase1Inherited
Carbamoyl phosphate synthetase, large subunit connection domain1Inherited
Actin-like ATPase domain1Inherited
"Winged helix" DNA-binding domain1Inherited
Methylglyoxal synthase-like1Inherited
PreATP-grasp domain1Inherited
Aminoacid dehydrogenase-like, N-terminal domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55681,50037
  • 55681 - Class II aaRS and biotin synthetases
  • 50037 - C-terminal domain of transcriptional repressors
  • 0Direct
    82829,56037
  • 82829 - MesJ substrate recognition domain-like
  • 56037 - PheT/TilS domain
  • 0Direct
    -7,52317
  • -7 - CATH
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    50037,53067
  • 50037 - C-terminal domain of transcriptional repressors
  • 53067 - Actin-like ATPase domain
  • 0Direct
    52402,56037
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 56037 - PheT/TilS domain
  • 0Direct
    52540,52317
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    50891,160467
  • 50891 - Cyclophilin-like
  • 160467 - PH0987 N-terminal domain-like
  • 0Direct
    54675,51690
  • 54675 - Nicotinate/Quinolinate PRTase N-terminal domain-like
  • 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like
  • 0Direct
    52402,69864
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 69864 - Argininosuccinate synthetase, C-terminal domain
  • 0Direct
    56042,53328
  • 56042 - PurM C-terminal domain-like
  • 53328 - Formyltransferase
  • 0Direct
    56037,53271
  • 56037 - PheT/TilS domain
  • 53271 - PRTase-like
  • 0Direct
    51246,55326
  • 51246 - Rudiment single hybrid motif
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    52402,82829
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 82829 - MesJ substrate recognition domain-like
  • 0Direct
    52540,-7
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -7 - CATH
  • 0.00000000003963Direct
    46785,55681
  • 46785 - "Winged helix" DNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0.000000002203Direct
    160467,50891
  • 160467 - PH0987 N-terminal domain-like
  • 50891 - Cyclophilin-like
  • 0.000001732Direct
    52317,52440
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0.5581Inherited
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 1Inherited
    56059,52335
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 1Inherited
    52021,52317
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 1Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited
    56042,55326
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 1Inherited
    56059,48108
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 1Inherited
    56235,52402
  • 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 1Inherited
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 1Inherited
    48108,52440
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    82829,56037,53271
  • 82829 - MesJ substrate recognition domain-like
  • 56037 - PheT/TilS domain
  • 53271 - PRTase-like
  • 0Direct
    52402,82829,56037
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 82829 - MesJ substrate recognition domain-like
  • 56037 - PheT/TilS domain
  • 0Direct
    56059,51246,55326
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    52540,-7,52317
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -7 - CATH
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    50891,160467,50891
  • 50891 - Cyclophilin-like
  • 160467 - PH0987 N-terminal domain-like
  • 50891 - Cyclophilin-like
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    55681,50037,53067
  • 55681 - Class II aaRS and biotin synthetases
  • 50037 - C-terminal domain of transcriptional repressors
  • 53067 - Actin-like ATPase domain
  • 0Direct
    46785,55681,50037
  • 46785 - "Winged helix" DNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 50037 - C-terminal domain of transcriptional repressors
  • 0Direct
    51246,55326,56042
  • 51246 - Rudiment single hybrid motif
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    50037,53067,53067
  • 50037 - C-terminal domain of transcriptional repressors
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    55326,56042,53328
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 53328 - Formyltransferase
  • 0Direct
    52021,52317,52440
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0.5581Inherited
    52317,52440,56059
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.5581Inherited
    56042,55326,56042
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 1Inherited
    56059,48108,52440
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 1Inherited
    52440,56059,48108
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 1Inherited
    55326,56042,55326
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 1Inherited
    52440,56059,52335
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 1Inherited
    48108,52440,56059
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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