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Enzyme Commission (EC): Carbon--nitrogen ligases with glutamine as amido-N-donor

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Ligases [6] <6>(96|123) (95|112|69)
+ 1:   Forming carbon-nitrogen bonds [6.3] <5>(59|78) (58|59|38)
0:   Carbon--nitrogen ligases with glutamine as amido-N-donor [6.3.5] <13>(20|17) (20|19|15)
- 1:   Adenosylcobyric acid synthase (glutamine-hydrolyzing) [6.3.5.10](0|0) (0|0|0)
- 1:   Asparagine synthase (glutamine-hydrolyzing) [6.3.5.4](2|2) (2|1|0)
- 1:   Asparaginyl-tRNA synthase (glutamine-hydrolyzing) [6.3.5.6](0|0) (0|0|0)
- 1:   Carbamoyl-phosphate synthase (glutamine-hydrolyzing) [6.3.5.5](8|7) (8|8|8)
- 1:   Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing) [6.3.5.11](2|0) (2|1|0)
- 1:   GMP synthase (glutamine-hydrolyzing) [6.3.5.2](3|3) (3|3|2)
- 1:   Glutaminyl-tRNA synthase (glutamine-hydrolyzing) [6.3.5.7](1|1) (1|0|0)
- 1:   Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing) [6.3.5.9](1|0) (1|1|0)
- 1:   Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) [6.3.5.13](1|0) (1|0|0)
- 1:   NAD(+) synthase (glutamine-hydrolyzing) [6.3.5.1](2|1) (2|1|0)
- 1:   Ni-sirohydrochlorin a,c-diamide synthase [6.3.5.12](1|0) (1|1|0)
- 1:   Phosphoribosylformylglycinamidine synthase [6.3.5.3](4|5) (4|5|5)
- 1:   Transferred entry: 2.6.1.85 [6.3.5.8](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Methylglyoxal synthase-like0Direct
PurM C-terminal domain-like0Direct
GMP synthetase C-terminal dimerisation domain0Direct
PurM N-terminal domain-like0Direct
Carbamoyl phosphate synthetase, large subunit connection domain0Direct
FGAM synthase PurL, linker domain0Direct
Amidase signature (AS) enzymes0Direct
PurS-like0Direct
Class I glutamine amidotransferase-like0Direct
Carbamoyl phosphate synthetase, small subunit N-terminal domain0Direct
Carbon-nitrogen hydrolase0.000000000000916Direct
Adenine nucleotide alpha hydrolases-like0.00000000012Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000008155Direct
PreATP-grasp domain0.3515Inherited
Aspartate/ornithine carbamoyltransferase0.5947Inherited
Glutathione synthetase ATP-binding domain-like0.7131Inherited
Composite domain of metallo-dependent hydrolases0.8244Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
MurD-like peptide ligases, catalytic domain1Inherited
Metallo-dependent hydrolases1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Carbamoyl phosphate synthetase, large subunit connection domain0Direct
BC N-terminal domain-like0Direct
Carbamoyl phosphate synthetase, small subunit N-terminal domain0Direct
PurM N-terminal domain-like0Direct
GMP synthetase C-terminal dimerisation domain0Direct
FGAM synthase PurL, linker domain0Direct
PurM C-terminal domain-like0Direct
FGAM synthase PurL, PurS-like domain0Direct
N-type ATP pyrophosphatases0Direct
Class I glutamine amidotransferases (GAT)0Direct
PurS subunit of FGAM synthetase0Direct
Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain0Direct
Class II glutamine amidotransferases0Direct
Amidase signature (AS) enzymes0Direct
BC ATP-binding domain-like0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0.00001987Direct
Aspartate/ornithine carbamoyltransferase0.6346Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PurM C-terminal domain-like0Direct
Carbamoyl phosphate synthetase, small subunit N-terminal domain0Direct
Amidase signature (AS) enzymes0Direct
PurM N-terminal domain-like0Direct
PurS-like0Direct
Carbamoyl phosphate synthetase, large subunit connection domain0Direct
GMP synthetase C-terminal dimerisation domain0Direct
Methylglyoxal synthase-like0Direct
Class I glutamine amidotransferase-like0Direct
FGAM synthase PurL, linker domain0Direct
Carbon-nitrogen hydrolase0.0000000000006579Direct
Adenine nucleotide alpha hydrolases-like0.00000000008834Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000006358Direct
PreATP-grasp domain0.3181Inherited
Aspartate/ornithine carbamoyltransferase0.546Inherited
Glutathione synthetase ATP-binding domain-like0.656Inherited
Composite domain of metallo-dependent hydrolases0.7598Inherited
Metallo-dependent hydrolases0.994Inherited
MurD-like peptide ligases, catalytic domain1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52402,54810
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 0Direct
    82697,109736
  • 82697 - PurS-like
  • 109736 - FGAM synthase PurL, linker domain
  • 0Direct
    56317,52402
  • 56317 - Carbon-nitrogen hydrolase
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    56059,52335
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 0Direct
    109736,55326
  • 109736 - FGAM synthase PurL, linker domain
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    56042,52317
  • 56042 - PurM C-terminal domain-like
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    52021,52317
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    52335,51556
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    52317,52402
  • 52317 - Class I glutamine amidotransferase-like
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 0Direct
    56042,55326
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    56059,48108
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 0Direct
    56235,52402
  • 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 0Direct
    54810,54810
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 0Direct
    48108,52440
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    52317,52440
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0.00001419Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.09914Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.2278Inherited
    52540,52317
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52317 - Class I glutamine amidotransferase-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56042,55326,56042
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    52335,51556,51338
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    56059,48108,52440
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    55326,56042,52317
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    56059,52335,51556
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    52402,54810,54810
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 0Direct
    52440,56059,48108
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 0Direct
    82697,109736,55326
  • 82697 - PurS-like
  • 109736 - FGAM synthase PurL, linker domain
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    52317,52402,54810
  • 52317 - Class I glutamine amidotransferase-like
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 0Direct
    55326,56042,55326
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    52440,56059,52335
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 0Direct
    109736,55326,56042
  • 109736 - FGAM synthase PurL, linker domain
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    48108,52440,56059
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    52021,52317,52440
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0.00001419Direct
    52317,52440,56059
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.00001419Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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