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Phenotypic Abnormality (PA): Abnormality of the genitourinary system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the genitourinary system [HP:0000119] <5>(73|72) (80|28|9)
- 1:   Urogenital fistula [HP:0100589] <5>(1|0) (1|0|0)
- 1:   Abnormality of the urinary system [HP:0000079] <4>(38|41) (45|15|7)
- 1:   Neoplasm of the genitourinary tract [HP:0007379] <4>(7|6) (9|2|1)
- 1:   Abnormality of the genital system [HP:0000078] <3>(35|34) (37|10|3)
- 1:   Cloacal abnormality [HP:0012620] <2>(0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Tricorn protease domain 20Direct
Putative DNA-binding domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Methylglyoxal synthase-like0Direct
Sec63 N-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
DNA-glycosylase0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Restriction endonuclease-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
DNA repair protein MutS, domain III0Direct
Smc hinge domain0Direct
SAND domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
PRTase-like0Direct
ARID-like0Direct
Zn-finger domain of Sec23/240Direct
Insulin-like0Direct
NAD kinase/diacylglycerol kinase-like0Direct
Ribonuclease H-like0.01283Inherited
ClpP/crotonase0.02018Inherited
Alkaline phosphatase-like0.0222Inherited
RING/U-box0.0243Inherited
NagB/RpiA/CoA transferase-like0.03978Inherited
Bromodomain0.04646Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.04838Inherited
SET domain0.05952Inherited
(Trans)glycosidases0.06314Inherited
Transcription factor STAT-4 N-domain0.064Inherited
STAT0.064Inherited
"Winged helix" DNA-binding domain0.06767Inherited
Clavaminate synthase-like0.07118Inherited
BRCT domain0.07282Inherited
WD40 repeat-like0.07951Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1024Inherited
Acyl-CoA dehydrogenase NM domain-like0.1024Inherited
CalX-like0.1027Inherited
GroEL equatorial domain-like0.1027Inherited
HMG-box0.1111Inherited
Actin-like ATPase domain0.1117Inherited
C-type lectin-like0.1448Inherited
FYVE/PHD zinc finger0.16Inherited
Adenine nucleotide alpha hydrolases-like0.1607Inherited
GAF domain-like0.1634Inherited
RuvA domain 2-like0.1634Inherited
L-aspartase-like0.1634Inherited
4Fe-4S ferredoxins0.1634Inherited
Homeodomain-like0.1674Inherited
Protein kinase-like (PK-like)0.1777Inherited
HD-domain/PDEase-like0.202Inherited
PreATP-grasp domain0.202Inherited
MHC antigen-recognition domain0.233Inherited
RNA-binding domain, RBD0.2788Inherited
Glutathione synthetase ATP-binding domain-like0.3319Inherited
Acyl-CoA N-acyltransferases (Nat)0.3325Inherited
TPR-like0.3412Inherited
Clc chloride channel0.3734Inherited
Chromo domain-like0.4005Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4081Inherited
Nuclear receptor ligand-binding domain0.4109Inherited
Fibrinogen C-terminal domain-like0.5192Inherited
Cysteine-rich domain0.5359Inherited
Mitochondrial carrier0.5391Inherited
Trypsin-like serine proteases0.6044Inherited
Cytochrome P4500.6134Inherited
Ribosomal protein S5 domain 2-like0.6957Inherited
Complement control module/SCR domain0.7563Inherited
L domain-like0.8311Inherited
Family A G protein-coupled receptor-like0.8453Inherited
Cytokine0.8572Inherited
DEATH domain0.954Inherited
TNF-like0.9761Inherited
Immunoglobulin1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
DNA repair protein MutS, domain III0Direct
DNA gyrase/MutL, second domain0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Lamin A/C globular tail domain0Direct
Cytochrome b50Direct
ARID domain0Direct
beta-glycanases0Direct
Diacylglycerol kinase-like0Direct
Cystathionine synthase-like0Direct
Smc hinge domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Insulin-like0Direct
DIX domain0Direct
HCDH C-domain-like0Direct
Dual specificity phosphatase-like0Direct
Integrin alpha N-terminal domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Phosphoribosyltransferases (PRTases)0Direct
Fibrinogen coiled-coil and central regions0Direct
DNA gyrase/MutL, N-terminal domain0Direct
DNA polymerase I0Direct
Sec63 N-terminal domain0Direct
IF2B-like0Direct
TBP-associated factors, TAFs0Direct
PHD domain0.001068Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.01036Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.01036Inherited
Bromodomain0.03684Inherited
Arylsulfatase0.03804Inherited
Histone lysine methyltransferases0.03804Inherited
RecA protein-like (ATPase-domain)0.03804Inherited
BC N-terminal domain-like0.05109Inherited
POU-specific domain0.05109Inherited
Transcription factor STAT-4 N-domain0.05109Inherited
Crotonase-like0.05109Inherited
STAT DNA-binding domain0.05109Inherited
STAT0.05109Inherited
BC ATP-binding domain-like0.05109Inherited
CalX-beta domain0.08465Inherited
RING finger domain, C3HC40.09462Inherited
HMG-box0.09462Inherited
GAF domain0.1387Inherited
Extended AAA-ATPase domain0.1629Inherited
Cytoplasmic domain of inward rectifier potassium channel0.1762Inherited
Actin/HSP700.1762Inherited
Noncollagenous (NC1) domain of collagen IV0.2039Inherited
Extracellular domain of cell surface receptors0.2039Inherited
Homeodomain0.2044Inherited
MHC antigen-recognition domain0.2059Inherited
PDEase0.247Inherited
WD40-repeat0.3017Inherited
C1 set domains (antibody constant domain-like)0.3201Inherited
ABC transporter ATPase domain-like0.3314Inherited
Clc chloride channel0.341Inherited
Chromo domain0.3685Inherited
Nuclear receptor0.3772Inherited
Nuclear receptor ligand-binding domain0.3847Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.404Inherited
Canonical RBD0.4067Inherited
Fibrinogen C-terminal domain-like0.4881Inherited
Mitochondrial carrier0.5106Inherited
Fibroblast growth factors (FGF)0.5984Inherited
Eukaryotic proteases0.6459Inherited
Cytochrome P4500.661Inherited
Complement control module/SCR domain0.7373Inherited
Rhodopsin-like0.8108Inherited
TNF-like0.9699Inherited
Ngr ectodomain-like0.9796Inherited
Voltage-gated potassium channels0.9867Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Insulin-like0Direct
ARID-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Tricorn protease domain 20Direct
NAD kinase/diacylglycerol kinase-like0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Restriction endonuclease-like0Direct
SAND domain-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Putative DNA-binding domain0Direct
DNA-glycosylase0Direct
DNA repair protein MutS, domain III0Direct
PRTase-like0Direct
Sec63 N-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
Zn-finger domain of Sec23/240Direct
Methylglyoxal synthase-like0Direct
Ribonuclease H-like0.008418Inherited
Integrin domains0.009622Inherited
ClpP/crotonase0.01375Inherited
Alkaline phosphatase-like0.01526Inherited
RING/U-box0.01678Inherited
DNA/RNA polymerases0.0286Inherited
NagB/RpiA/CoA transferase-like0.0286Inherited
Bromodomain0.03393Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03548Inherited
SET domain0.04462Inherited
(Trans)glycosidases0.04766Inherited
Transcription factor STAT-4 N-domain0.04835Inherited
STAT0.04835Inherited
"Winged helix" DNA-binding domain0.05137Inherited
Clavaminate synthase-like0.05429Inherited
BRCT domain0.05564Inherited
WD40 repeat-like0.06123Inherited
Acyl-CoA dehydrogenase NM domain-like0.08052Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.08052Inherited
CalX-like0.08086Inherited
GroEL equatorial domain-like0.08086Inherited
HMG-box0.08772Inherited
Actin-like ATPase domain0.08821Inherited
C-type lectin-like0.1179Inherited
FYVE/PHD zinc finger0.1312Inherited
Adenine nucleotide alpha hydrolases-like0.1317Inherited
RuvA domain 2-like0.1339Inherited
GAF domain-like0.1339Inherited
L-aspartase-like0.1339Inherited
4Fe-4S ferredoxins0.1339Inherited
Homeodomain-like0.1376Inherited
Protein kinase-like (PK-like)0.1468Inherited
PreATP-grasp domain0.1691Inherited
lambda repressor-like DNA-binding domains0.1691Inherited
HD-domain/PDEase-like0.1691Inherited
MHC antigen-recognition domain0.1976Inherited
RNA-binding domain, RBD0.2403Inherited
Glutathione synthetase ATP-binding domain-like0.2906Inherited
Acyl-CoA N-acyltransferases (Nat)0.2912Inherited
TPR-like0.2997Inherited
E set domains0.3044Inherited
Clc chloride channel0.3305Inherited
Chromo domain-like0.3572Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3647Inherited
Nuclear receptor ligand-binding domain0.3674Inherited
CBS-domain pair0.3755Inherited
ARM repeat0.3963Inherited
Fibrinogen C-terminal domain-like0.4749Inherited
Cysteine-rich domain0.4918Inherited
Mitochondrial carrier0.4951Inherited
Trypsin-like serine proteases0.5621Inherited
Cytochrome P4500.5715Inherited
Ribosomal protein S5 domain 2-like0.6568Inherited
Complement control module/SCR domain0.7194Inherited
L domain-like0.7977Inherited
Family A G protein-coupled receptor-like0.8125Inherited
Cytokine0.8252Inherited
DEATH domain0.929Inherited
TNF-like0.9531Inherited
Voltage-gated potassium channels0.9641Inherited
Immunoglobulin0.9871Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.02244Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04835Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04835Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.04835Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.05564Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.07208Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.08052Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1339Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.1339Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.1339Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.1691Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.197Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1976Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.4643Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.4951Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04835Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04835Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.08052Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08606Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1182Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1339Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.4749Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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