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Phenotypic Abnormality (PA): Abnormality of the nervous system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
- 1:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
- 1:   Abnormality of nervous system morphology [HP:0012639] <5>(70|97) (81|48|16)
- 1:   Abnormality of the peripheral nervous system [HP:0410008] <3>(2|1) (2|2|0)
- 1:   Abnormality of ganglion [HP:0410014] <2>(0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
SNARE fusion complex0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Smc hinge domain0Direct
Transcription factor STAT-4 N-domain0Direct
S15/NS1 RNA-binding domain0Direct
SNF-like0Direct
Nicotinic receptor ligand binding domain-like0Direct
Adenine nucleotide alpha hydrolases-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
CalX-like0Direct
Pseudouridine synthase0Direct
EF-G C-terminal domain-like0Direct
GroEL apical domain-like0Direct
Notch domain0Direct
A DNA-binding domain in eukaryotic transcription factors0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Lamin A/C globular tail domain0Direct
BRK domain-like0Direct
GroEL equatorial domain-like0Direct
GAF domain-like0Direct
L-aspartase-like0Direct
Fibrinogen coiled-coil and central regions0Direct
UBA-like0Direct
Arginase/deacetylase0Direct
Calcium-dependent phosphotriesterase0Direct
ThrRS/AlaRS common domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
LuxS/MPP-like metallohydrolase0Direct
ADC-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
CCCH zinc finger0Direct
Hook domain0Direct
CRAL/TRIO domain0Direct
Actin depolymerizing proteins0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
TB module/8-cys domain0Direct
GroEL-intermediate domain like0Direct
Methylglyoxal synthase-like0Direct
Restriction endonuclease-like0Direct
Translation proteins0Direct
STAT0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Putative DNA-binding domain0Direct
Helical domain of Sec23/240Direct
4Fe-4S ferredoxins0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Subtilisin-like0Direct
Ribonuclease PH domain 2-like0Direct
Tricorn protease domain 20Direct
Proton glutamate symport protein0Direct
DBL homology domain (DH-domain)0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Hect, E3 ligase catalytic domain0Direct
JAB1/MPN domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
RuvA domain 2-like0Direct
Cyclin-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Zn-finger domain of Sec23/240Direct
GroES-like0Direct
HIT-like0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
beta-sandwich domain of Sec23/240Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
SAND domain-like0Direct
Alkaline phosphatase-like0Direct
DNA/RNA polymerases0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
CoA-dependent acyltransferases0Direct
FKBP-like0Direct
Apolipoprotein A-I0Direct
Nucleoside diphosphate kinase, NDK0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Thiolase-like0Direct
PP2C-like0Direct
Multidrug resistance efflux transporter EmrE0Direct
L27 domain0Direct
Nucleotidylyl transferase0.01769Inherited
Voltage-gated potassium channels0.03722Inherited
Ribosomal protein S5 domain 2-like0.0402Inherited
Bromodomain0.04874Inherited
Actin-like ATPase domain0.05939Inherited
ARM repeat0.06283Inherited
cAMP-binding domain-like0.07247Inherited
Ribonuclease H-like0.08792Inherited
Nucleotide-diphospho-sugar transferases0.09091Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1289Inherited
Acyl-CoA dehydrogenase NM domain-like0.1289Inherited
(Trans)glycosidases0.1401Inherited
Periplasmic binding protein-like II0.1556Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1575Inherited
WD40 repeat-like0.1747Inherited
Class II aaRS and biotin synthetases0.1836Inherited
Single hybrid motif0.1877Inherited
PreATP-grasp domain0.1877Inherited
Glycosyl hydrolase domain0.1877Inherited
Chaperone J-domain0.2611Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.271Inherited
GST C-terminal domain-like0.2723Inherited
GLA-domain0.2723Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.2723Inherited
MIR domain0.2723Inherited
POZ domain0.2814Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.3017Inherited
SET domain0.3066Inherited
ARID-like0.3278Inherited
HSP20-like chaperones0.3278Inherited
Cysteine proteinases0.3282Inherited
RNI-like0.3469Inherited
Periplasmic binding protein-like I0.3909Inherited
Kelch motif0.3909Inherited
FabD/lysophospholipase-like0.3966Inherited
Sema domain0.46Inherited
SH2 domain0.4634Inherited
Cap-Gly domain0.4786Inherited
DNA repair protein MutS, domain III0.4786Inherited
Rudiment single hybrid motif0.4786Inherited
Anaphylotoxins (complement system)0.4786Inherited
Mitochondrial carrier0.5067Inherited
Thioredoxin-like0.5187Inherited
Alpha-macroglobulin receptor domain0.5237Inherited
p53-like transcription factors0.5342Inherited
RNA-binding domain, RBD0.5761Inherited
NagB/RpiA/CoA transferase-like0.593Inherited
MHC antigen-recognition domain0.5996Inherited
Tubulin nucleotide-binding domain-like0.6035Inherited
Nuclear receptor ligand-binding domain0.6449Inherited
Tubulin C-terminal domain-like0.6542Inherited
Fibrinogen C-terminal domain-like0.6595Inherited
Terpenoid cyclases/Protein prenyltransferases0.6595Inherited
Myosin rod fragments0.6595Inherited
Integrin domains0.7208Inherited
ClpP/crotonase0.7583Inherited
Tropomyosin0.7832Inherited
PH domain-like0.7917Inherited
vWA-like0.8344Inherited
KRAB domain (Kruppel-associated box)0.9005Inherited
TIMP-like0.9027Inherited
Snake toxin-like0.9078Inherited
DEATH domain0.9499Inherited
Intermediate filament protein, coiled coil region0.9667Inherited
Homeodomain-like0.9739Inherited
Cytochrome P4500.9993Inherited
Immunoglobulin1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
a tRNA synthase domain0Direct
beta-glycanases0Direct
Myotubularin-like phosphatases0Direct
Ferredoxin domains from multidomain proteins0Direct
FAD/NAD-linked reductases, N-terminal and central domains0Direct
GAF domain0Direct
CAT-like0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0Direct
Glycosyl transferases group 10Direct
beta-sandwich domain of Sec23/240Direct
Single strand DNA-binding domain, SSB0Direct
DNA polymerase I0Direct
Lamin A/C globular tail domain0Direct
Histone lysine methyltransferases0Direct
Amylase, catalytic domain0Direct
UBA domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
MPP-like0Direct
Caspase recruitment domain, CARD0Direct
L27 domain0Direct
CCCH zinc finger0Direct
Long-chain cytokines0Direct
DBL homology domain (DH-domain)0Direct
FKBP immunophilin/proline isomerase0Direct
Prefoldin0Direct
RhoGDI-like0Direct
Smc hinge domain0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Pyridoxal-dependent decarboxylase0Direct
IF2B-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
p120GAP domain-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
PWWP domain0Direct
PP2C-like0Direct
Proton glutamate symport protein0Direct
Filamin repeat (rod domain)0Direct
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0Direct
DNA gyrase/MutL, second domain0Direct
Apolipoprotein A-I0Direct
Anticodon-binding domain0Direct
Histone deacetylase, HDAC0Direct
Subtilases0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
N-acetyl transferase, NAT0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
SPRY domain0Direct
JAB1/MPN domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Phosphate binding protein-like0Direct
Cyclin0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Fibrinogen coiled-coil and central regions0Direct
SNARE fusion complex0Direct
TBP-associated factors, TAFs0Direct
SNF-like0Direct
DNA gyrase/MutL, N-terminal domain0Direct
Translational machinery components0Direct
Ribonuclease PH domain 1-like0Direct
STAT DNA-binding domain0Direct
L-aspartase/fumarase0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
Ribonuclease PH domain 2-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Choline/Carnitine O-acyltransferase0Direct
Elongation factors0Direct
Arylsulfatase0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
STAT0Direct
DEP domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0Direct
Clathrin adaptor core protein0Direct
Exostosin0Direct
Hect, E3 ligase catalytic domain0Direct
Trunk domain of Sec23/240Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
EF-G/eEF-2 domains III and V0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Zn-finger domain of Sec23/240Direct
Cold shock DNA-binding domain-like0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Notch domain0Direct
CUT domain0Direct
A DNA-binding domain in eukaryotic transcription factors0Direct
TB module/8-cys domain0Direct
SWIRM domain0Direct
Putative glucosidase YicI, domain 30Direct
Cytochrome b50Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Protein serine/threonine phosphatase0Direct
Nicotinic receptor ligand binding domain-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
CalX-beta domain0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
Helical domain of Sec23/240Direct
BRK domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
G proteins0.02617Inherited
Bromodomain0.03496Inherited
Voltage-gated potassium channels0.07137Inherited
Extended AAA-ATPase domain0.07958Inherited
Tyrosine-dependent oxidoreductases0.07958Inherited
cAMP-binding domain0.08262Inherited
PHD domain0.1097Inherited
FHA domain0.1254Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.1539Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1539Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.1539Inherited
HMG-box0.1717Inherited
Actin/HSP700.1897Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1897Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2199Inherited
Chaperone J-domain0.2199Inherited
Transforming growth factor (TGF)-beta0.228Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.228Inherited
MIR domain0.2329Inherited
GLA-domain0.2329Inherited
Tetramerization domain of potassium channels0.2585Inherited
BC ATP-binding domain-like0.2854Inherited
ARID domain0.2854Inherited
Clathrin coat assembly domain0.2854Inherited
BC N-terminal domain-like0.2854Inherited
Kelch motif0.3423Inherited
Pyrin domain, PYD0.352Inherited
28-residue LRR0.3543Inherited
Transducin (alpha subunit), insertion domain0.3543Inherited
SH2 domain0.41Inherited
Sema domain0.4131Inherited
BC C-terminal domain-like0.4337Inherited
Anaphylotoxins (complement system)0.4337Inherited
Glutathione S-transferase (GST), C-terminal domain0.4337Inherited
Cap-Gly domain0.4337Inherited
DNA repair protein MutS, domain III0.4337Inherited
Netrin-like domain (NTR/C345C module)0.4337Inherited
ZZ domain0.4337Inherited
L-arabinose binding protein-like0.4405Inherited
Mitochondrial carrier0.4567Inherited
Alpha-macroglobulin receptor domain0.4766Inherited
Complement components0.4766Inherited
Nuclear receptor0.515Inherited
VWC domain0.5488Inherited
MHC antigen-recognition domain0.5543Inherited
Tubulin, GTPase domain0.5565Inherited
PDZ domain0.5573Inherited
Nuclear receptor ligand-binding domain0.5975Inherited
Tubulin, C-terminal domain0.6103Inherited
C1 set domains (antibody constant domain-like)0.6103Inherited
RecA protein-like (ATPase-domain)0.6175Inherited
Myosin rod fragments0.6175Inherited
Fibrinogen C-terminal domain-like0.6175Inherited
Canonical RBD0.6272Inherited
Ras-binding domain, RBD0.6288Inherited
Integrin domains0.6829Inherited
Tropomyosin0.7501Inherited
ABC transporter ATPase domain-like0.7666Inherited
Integrin A (or I) domain0.7765Inherited
T-box0.7989Inherited
KRAB domain (Kruppel-associated box)0.8786Inherited
Crotonase-like0.8786Inherited
Intermediate filament protein, coiled coil region0.9498Inherited
Complement control module/SCR domain0.9695Inherited
Cytochrome P4500.9702Inherited
Nucleotide and nucleoside kinases0.984Inherited
Homeodomain0.9866Inherited
Second domain of FERM0.9948Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nucleoside diphosphate kinase, NDK0Direct
LuxS/MPP-like metallohydrolase0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
beta-sandwich domain of Sec23/240Direct
JAB1/MPN domain0Direct
HIT-like0Direct
SAND domain-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Subtilisin-like0Direct
GroEL equatorial domain-like0Direct
GAF domain-like0Direct
PP2C-like0Direct
L27 domain0Direct
BRK domain-like0Direct
Nicotinic receptor ligand binding domain-like0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
CalX-like0Direct
S15/NS1 RNA-binding domain0Direct
CRAL/TRIO domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
GroEL-intermediate domain like0Direct
Multidrug resistance efflux transporter EmrE0Direct
ADC-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Smc hinge domain0Direct
Tricorn protease domain 20Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
ValRS/IleRS/LeuRS editing domain0Direct
A DNA-binding domain in eukaryotic transcription factors0Direct
Adenine nucleotide alpha hydrolases-like0Direct
GroEL apical domain-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Hect, E3 ligase catalytic domain0Direct
Ribonuclease PH domain 2-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Arginase/deacetylase0Direct
GroES-like0Direct
Thiolase-like0Direct
Apolipoprotein A-I0Direct
Helical domain of Sec23/240Direct
Pseudouridine synthase0Direct
RuvA domain 2-like0Direct
Restriction endonuclease-like0Direct
Transcription factor STAT-4 N-domain0Direct
Hook domain0Direct
DNA/RNA polymerases0Direct
TB module/8-cys domain0Direct
SNF-like0Direct
UBA-like0Direct
Actin depolymerizing proteins0Direct
STAT0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
DBL homology domain (DH-domain)0Direct
FKBP-like0Direct
Calcium-dependent phosphotriesterase0Direct
EF-G C-terminal domain-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Proton glutamate symport protein0Direct
CCCH zinc finger0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Methylglyoxal synthase-like0Direct
Fibrinogen coiled-coil and central regions0Direct
SNARE fusion complex0Direct
CoA-dependent acyltransferases0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
4Fe-4S ferredoxins0Direct
Zn-finger domain of Sec23/240Direct
Lamin A/C globular tail domain0Direct
Notch domain0Direct
Cyclin-like0Direct
ThrRS/AlaRS common domain0Direct
Alkaline phosphatase-like0Direct
Putative DNA-binding domain0Direct
Translation proteins0Direct
L-aspartase-like0Direct
Nucleotidylyl transferase0.012Inherited
Voltage-gated potassium channels0.02692Inherited
Ribosomal protein S5 domain 2-like0.0292Inherited
Bromodomain0.03621Inherited
Actin-like ATPase domain0.04495Inherited
ARM repeat0.04776Inherited
cAMP-binding domain-like0.05564Inherited
Ribonuclease H-like0.06859Inherited
Nucleotide-diphospho-sugar transferases0.07118Inherited
Acyl-CoA dehydrogenase NM domain-like0.1042Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1042Inherited
Glutathione synthetase ATP-binding domain-like0.1042Inherited
(Trans)glycosidases0.1143Inherited
Periplasmic binding protein-like II0.1281Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1298Inherited
WD40 repeat-like0.1447Inherited
Class II aaRS and biotin synthetases0.153Inherited
Glycosyl hydrolase domain0.1567Inherited
Single hybrid motif0.1567Inherited
PreATP-grasp domain0.1567Inherited
BRCT domain0.1567Inherited
HMG-box0.1768Inherited
Chaperone J-domain0.2246Inherited
"Winged helix" DNA-binding domain0.2309Inherited
Cystine-knot cytokines0.232Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.2343Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.2354Inherited
MIR domain0.2354Inherited
GST C-terminal domain-like0.2354Inherited
GLA-domain0.2354Inherited
POZ domain0.2439Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.2634Inherited
SET domain0.268Inherited
HSP20-like chaperones0.2882Inherited
ARID-like0.2882Inherited
Cysteine proteinases0.2886Inherited
FAD/NAD(P)-binding domain0.2983Inherited
RNI-like0.3064Inherited
Kelch motif0.3489Inherited
Periplasmic binding protein-like I0.3489Inherited
FabD/lysophospholipase-like0.3547Inherited
Transducin (alpha subunit), insertion domain0.359Inherited
Sema domain0.417Inherited
SH2 domain0.4205Inherited
DNA repair protein MutS, domain III0.4352Inherited
Cap-Gly domain0.4352Inherited
Anaphylotoxins (complement system)0.4352Inherited
Rudiment single hybrid motif0.4352Inherited
Mitochondrial carrier0.4632Inherited
Thioredoxin-like0.4753Inherited
SMAD/FHA domain0.4753Inherited
Alpha-macroglobulin receptor domain0.4804Inherited
p53-like transcription factors0.4911Inherited
RNA-binding domain, RBD0.5342Inherited
NagB/RpiA/CoA transferase-like0.5514Inherited
MHC antigen-recognition domain0.5583Inherited
Tubulin nucleotide-binding domain-like0.5624Inherited
Nuclear receptor ligand-binding domain0.6056Inherited
Tubulin C-terminal domain-like0.6151Inherited
Fibrinogen C-terminal domain-like0.6206Inherited
Myosin rod fragments0.6206Inherited
Terpenoid cyclases/Protein prenyltransferases0.6206Inherited
PDZ domain-like0.6363Inherited
Integrin domains0.6834Inherited
ClpP/crotonase0.7223Inherited
HAD-like0.7481Inherited
Tropomyosin0.7482Inherited
PH domain-like0.7571Inherited
vWA-like0.8017Inherited
(Phosphotyrosine protein) phosphatases II0.8322Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.8405Inherited
TNF receptor-like0.8405Inherited
Calcium ATPase, transmembrane domain M0.8529Inherited
KRAB domain (Kruppel-associated box)0.8716Inherited
TIMP-like0.8738Inherited
Snake toxin-like0.8793Inherited
Calcium ATPase, transduction domain A0.8861Inherited
DEATH domain0.9241Inherited
Intermediate filament protein, coiled coil region0.9427Inherited
Homeodomain-like0.9506Inherited
Complement control module/SCR domain0.9592Inherited
Cytochrome P4500.9797Inherited
Second domain of FERM0.9878Inherited
Immunoglobulin0.9978Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    49265,49899
  • 49265 - Fibronectin type III
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    81296,48239
  • 81296 - E set domains
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    50447,-8
  • 50447 - Translation proteins
  • -8 - ECOD
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    -8,54980
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04939Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.06859Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1042Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1567Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1914Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1921Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.3083Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.3547Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3547Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.359Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.417Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.417Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4352Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.4352Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.4352Inherited
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.4352Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.5583Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6081Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.6151Inherited
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.6294Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.658Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.7223Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.8405Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8794Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.9589Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    50447,-8,54980
  • 50447 - Translation proteins
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1042Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1921Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.4352Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.446Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.4804Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.658Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8269Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.8405Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9106Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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