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Phenotypic Abnormality (PA): Muscle weakness

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the musculature [HP:0003011] <3>(62|74) (69|31|7)
+ 1:   Abnormal muscle physiology [HP:0011804] <12>(43|55) (52|22|4)
0:   Muscle weakness [HP:0001324] <22>(14|14) (15|4|0)
- 1:   Distal muscle weakness [HP:0002460] <6>(1|0) (1|2|0)
- 1:   Proximal muscle weakness [HP:0003701] <5>(4|4) (4|2|0)
- 1:   Facial palsy [HP:0010628] <4>(0|0) (0|1|0)
- 1:   Limb muscle weakness [HP:0003690] <4>(5|4) (6|1|0)
- 1:   Weakness of muscles of respiration [HP:0004347] <4>(1|0) (1|2|0)
- 1:   Fatigable weakness [HP:0003473] <3>(6|6) (6|2|0)
- 1:   Limb-girdle muscle weakness [HP:0003325] <2>(3|3) (3|2|0)
- 1:   Abdominal wall muscle weakness [HP:0009023] <1>(0|0) (0|0|0)
- 1:   Abnormality of occipitofrontalis muscle [HP:0040172] <1>(0|0) (0|0|0)
- 1:   Diaphragmatic weakness [HP:0009113] <1>(1|1) (1|1|0)
- 1:   Muscle flaccidity [HP:0010547] <1>(1|0) (1|0|0)
- 1:   Neck muscle weakness [HP:0000467] <1>(3|3) (3|1|0)
- 1:   Progressive muscle weakness [HP:0003323] <1>(1|1) (1|1|0)
- 1:   Ankle weakness [HP:0031374](2|2) (2|1|0)
- 1:   Axial muscle weakness [HP:0003327](1|1) (1|0|0)
- 1:   Bulbar palsy [HP:0001283](0|0) (0|0|0)
- 1:   Cold paresis [HP:0031372](0|0) (0|0|0)
- 1:   Generalized muscle weakness [HP:0003324](2|2) (2|1|0)
- 1:   Intercostal muscle weakness [HP:0004878](0|0) (0|0|0)
- 1:   Poor head control [HP:0002421](1|1) (1|0|0)
- 1:   Scapuloperoneal weakness [HP:0003704](0|0) (0|0|0)
- 1:   Weakness of orbicularis oculi muscle [HP:0012507](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Ribonuclease PH domain 2-like0Direct
HSP20-like chaperones0.01302Inherited
Calcium-dependent phosphotriesterase0.01321Inherited
RNA-binding domain, RBD0.04874Inherited
S15/NS1 RNA-binding domain0.1051Inherited
MIR domain0.1075Inherited
Tropomyosin0.1447Inherited
SNARE fusion complex0.2294Inherited
Voltage-gated potassium channels0.4331Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.4855Inherited
Nicotinic receptor ligand binding domain-like0.5133Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.5133Inherited
Intermediate filament protein, coiled coil region0.5344Inherited
vWA-like0.6219Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Myotubularin-like phosphatases0Direct
Ribonuclease PH domain 1-like0Direct
Ribonuclease PH domain 2-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Myosin rod fragments0.02512Inherited
Canonical RBD0.05719Inherited
a tRNA synthase domain0.08841Inherited
MIR domain0.08841Inherited
Tropomyosin0.1254Inherited
SNARE fusion complex0.2043Inherited
Integrin A (or I) domain0.3883Inherited
Intermediate filament protein, coiled coil region0.489Inherited
Nicotinic receptor ligand binding domain-like0.4914Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4914Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Ribonuclease PH domain 2-like0Direct
HSP20-like chaperones0.008662Inherited
Calcium-dependent phosphotriesterase0.008799Inherited
Myosin rod fragments0.02481Inherited
RNA-binding domain, RBD0.0362Inherited
S15/NS1 RNA-binding domain0.08317Inherited
MIR domain0.08522Inherited
Tropomyosin0.1184Inherited
SNARE fusion complex0.1948Inherited
Voltage-gated potassium channels0.3902Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.4418Inherited
Nicotinic receptor ligand binding domain-like0.47Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.47Inherited
Intermediate filament protein, coiled coil region0.4914Inherited
vWA-like0.582Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.01178Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.02651Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.47Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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