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Phenotypic Abnormality (PA): Abnormality of the integument

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the integument [HP:0001574] <4>(48|69) (59|36|15)
- 1:   Abnormality of skin adnexa physiology [HP:0025276] <6>(2|2) (3|3|1)
- 1:   Abnormality of skin adnexa morphology [HP:0011138] <5>(16|19) (17|6|2)
- 1:   Abnormality of the skin [HP:0000951] <4>(34|55) (45|35|12)
- 1:   Abnormality of platysma [HP:3000013](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Caspase-like0Direct
Smc hinge domain0Direct
Notch domain0Direct
Integrin beta tail domain0Direct
Translation proteins SH3-like domain0Direct
HIT-like0Direct
Plakin repeat0Direct
SAND domain-like0Direct
Zn-finger domain of Sec23/240Direct
CCCH zinc finger0Direct
Apolipoprotein A-I0Direct
Tricorn protease domain 20Direct
RuvA domain 2-like0Direct
JAB1/MPN domain0Direct
DHS-like NAD/FAD-binding domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Lamin A/C globular tail domain0Direct
DEATH domain0.00245Inherited
Intermediate filament protein, coiled coil region0.02211Inherited
ABC transporter transmembrane region0.02604Inherited
MHC antigen-recognition domain0.03567Inherited
DNA/RNA polymerases0.04356Inherited
SH2 domain0.05081Inherited
Spectrin repeat0.05319Inherited
SET domain0.06813Inherited
Globin-like0.06908Inherited
Integrin domains0.08001Inherited
RING/U-box0.08556Inherited
GroEL equatorial domain-like0.1095Inherited
Bromodomain0.1248Inherited
HMG-box0.1261Inherited
(Trans)glycosidases0.1412Inherited
EGF/Laminin0.169Inherited
DNA repair protein MutS, domain III0.172Inherited
BRK domain-like0.172Inherited
Immunoglobulin0.1794Inherited
Complement control module/SCR domain0.2224Inherited
ARID-like0.2453Inherited
Histone-fold0.2453Inherited
Prefoldin0.2929Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3359Inherited
Nicotinic receptor ligand binding domain-like0.3359Inherited
BRCT domain0.4198Inherited
FnI-like domain0.4702Inherited
RNI-like0.4809Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.5406Inherited
Ribosomal protein S5 domain 2-like0.5664Inherited
alpha/beta-Hydrolases0.5817Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin reductase FAD-binding domain-like0Direct
Notch domain0Direct
Caspase catalytic domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Smc hinge domain0Direct
beta-glycanases0Direct
ets domain0Direct
Erythroid transcription factor GATA-10Direct
Integrin beta tail domain0Direct
Zn-finger domain of Sec23/240Direct
Gonadodropin/Follitropin0Direct
Lamin A/C globular tail domain0Direct
CCCH zinc finger0Direct
Histone deacetylase, HDAC0Direct
Proteasome subunits0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Exostosin0Direct
JAB1/MPN domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Integrin beta EGF-like domains0Direct
SWIRM domain0Direct
Apolipoprotein A-I0Direct
Plakin repeat0Direct
ABC transporter ATPase domain-like0.002685Inherited
Integrin A (or I) domain0.005311Inherited
C1 set domains (antibody constant domain-like)0.006857Inherited
Actin/HSP700.01214Inherited
Intermediate filament protein, coiled coil region0.01799Inherited
MHC antigen-recognition domain0.02791Inherited
GLA-domain0.03423Inherited
SH2 domain0.04334Inherited
Histone lysine methyltransferases0.04366Inherited
Spectrin repeat0.04397Inherited
Globins0.05632Inherited
DnaQ-like 3'-5' exonuclease0.05632Inherited
Integrin domains0.06705Inherited
Pyrin domain, PYD0.09163Inherited
DNA gyrase/MutL, N-terminal domain0.09163Inherited
DNA gyrase/MutL, second domain0.09163Inherited
Tyrosine-dependent oxidoreductases0.09559Inherited
TNF receptor-like0.09615Inherited
PHD domain0.09671Inherited
G proteins0.09893Inherited
Bromodomain0.1083Inherited
HMG-box0.1109Inherited
Hect, E3 ligase catalytic domain0.1368Inherited
Trunk domain of Sec23/240.1475Inherited
beta-sandwich domain of Sec23/240.1475Inherited
DNA repair protein MutS, domain III0.1475Inherited
BRK domain-like0.1475Inherited
Helical domain of Sec23/240.1475Inherited
C-terminal, gelsolin-like domain of Sec23/240.1475Inherited
VWC domain0.1487Inherited
DEATH domain, DD0.1936Inherited
Complement control module/SCR domain0.2021Inherited
EGF-type module0.2135Inherited
Ras-binding domain, RBD0.2181Inherited
ARID domain0.2181Inherited
Laminin-type module0.2529Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2652Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3121Inherited
Nicotinic receptor ligand binding domain-like0.3121Inherited
TBP-associated factors, TAFs0.3157Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.3615Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.4805Inherited
RecA protein-like (ATPase-domain)0.5138Inherited
Ngr ectodomain-like0.6297Inherited
Extended AAA-ATPase domain0.888Inherited
V set domains (antibody variable domain-like)0.9556Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SAND domain-like0Direct
Integrin beta tail domain0Direct
HIT-like0Direct
DHS-like NAD/FAD-binding domain0Direct
Tricorn protease domain 20Direct
CCCH zinc finger0Direct
Caspase-like0Direct
Smc hinge domain0Direct
Lamin A/C globular tail domain0Direct
Notch domain0Direct
RuvA domain 2-like0Direct
Plakin repeat0Direct
JAB1/MPN domain0Direct
Zn-finger domain of Sec23/240Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Apolipoprotein A-I0Direct
Translation proteins SH3-like domain0Direct
DEATH domain0.0014Inherited
Intermediate filament protein, coiled coil region0.01521Inherited
ABC transporter transmembrane region0.01807Inherited
MHC antigen-recognition domain0.02551Inherited
GLA-domain0.03159Inherited
DNA/RNA polymerases0.03159Inherited
P-loop containing nucleoside triphosphate hydrolases0.0332Inherited
SH2 domain0.03753Inherited
Spectrin repeat0.03947Inherited
SET domain0.05176Inherited
Globin-like0.05257Inherited
Integrin domains0.06165Inherited
RING/U-box0.06634Inherited
GroEL equatorial domain-like0.08632Inherited
Bromodomain0.09999Inherited
HMG-box0.1012Inherited
(Trans)glycosidases0.1147Inherited
Hect, E3 ligase catalytic domain0.1288Inherited
EGF/Laminin0.1391Inherited
Helical domain of Sec23/240.1416Inherited
C-terminal, gelsolin-like domain of Sec23/240.1416Inherited
DNA repair protein MutS, domain III0.1416Inherited
BRK domain-like0.1416Inherited
Immunoglobulin0.1484Inherited
Protein kinase-like (PK-like)0.1658Inherited
Complement control module/SCR domain0.1878Inherited
ARID-like0.2089Inherited
Histone-fold0.2089Inherited
Prefoldin0.2534Inherited
Nucleotide-diphospho-sugar transferases0.2748Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2946Inherited
Nicotinic receptor ligand binding domain-like0.2946Inherited
4-helical cytokines0.3115Inherited
Adenine nucleotide alpha hydrolases-like0.3478Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3478Inherited
BRCT domain0.3762Inherited
FnI-like domain0.4265Inherited
RNI-like0.4371Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.4968Inherited
Ribosomal protein S5 domain 2-like0.5232Inherited
alpha/beta-Hydrolases0.5389Inherited
L domain-like0.8927Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01807Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.02551Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.02551Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03987Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.05257Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.07578Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.08632Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08632Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.08632Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1268Inherited
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.1416Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1416Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1811Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.2202Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.253Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.2946Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.3115Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02551Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1288Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2534Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2534Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4527Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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