SUPERFAMILY 1.75 HMM library and genome assignments server

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Phenotypic Abnormality (PA): Abnormality of the cardiovascular system

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
- 1:   Abnormal cardiovascular system physiology [HP:0011025] <16>(21|34) (29|18|16)
- 1:   Abnormality of the vasculature [HP:0002597] <13>(35|56) (45|27|18)
- 1:   Abnormal cardiac test [HP:0500015] <7>(1|3) (1|1|0)
- 1:   Abnormality of the fetal cardiovascular system [HP:0010948] <7>(0|0) (0|0|0)
- 1:   Abnormality of cardiovascular system morphology [HP:0030680] <3>(29|42) (31|19|20)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
GLA-domain0Direct
Notch domain0Direct
Saposin0Direct
TB module/8-cys domain0Direct
GAF domain-like0Direct
DPP6 N-terminal domain-like0Direct
Creatinase/aminopeptidase0Direct
Plakin repeat0Direct
SAND domain-like0Direct
Zn-finger domain of Sec23/240Direct
Apolipoprotein A-I0Direct
Tricorn protease domain 20Direct
Sec1/munc18-like (SM) proteins0Direct
RmlC-like cupins0Direct
Fibrinogen coiled-coil and central regions0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Creatinase/prolidase N-terminal domain0Direct
Growth factor receptor domain0.01479Inherited
TNF receptor-like0.01631Inherited
Glycosyl hydrolase domain0.0177Inherited
Actin-like ATPase domain0.01898Inherited
Tropomyosin0.02887Inherited
(Trans)glycosidases0.03673Inherited
cAMP-binding domain-like0.04125Inherited
DEATH domain0.04388Inherited
DNA/RNA polymerases0.04575Inherited
Spectrin repeat0.05758Inherited
Globin-like0.07213Inherited
Protein kinase-like (PK-like)0.1047Inherited
SMAD MH1 domain0.1135Inherited
p53-like transcription factors0.1586Inherited
Myosin rod fragments0.1644Inherited
Trypsin-like serine proteases0.1694Inherited
Caspase-like0.1767Inherited
MIR domain0.178Inherited
4-helical cytokines0.1978Inherited
Snake toxin-like0.1978Inherited
Integrin domains0.2244Inherited
HMG-box0.2355Inherited
ARID-like0.2527Inherited
MHC antigen-recognition domain0.2604Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.303Inherited
FnI-like domain0.3135Inherited
TNF-like0.3135Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.3382Inherited
Fibrinogen C-terminal domain-like0.3382Inherited
SMAD/FHA domain0.3662Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.4009Inherited
Hemopexin-like domain0.4315Inherited
RNI-like0.4967Inherited
PGBD-like0.5398Inherited
Cadherin-like0.5881Inherited
Voltage-gated potassium channels0.6729Inherited
L domain-like0.7177Inherited
(Phosphotyrosine protein) phosphatases II0.855Inherited
Ribosomal protein S5 domain 2-like0.8625Inherited
FAD/NAD(P)-binding domain0.8976Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9711Inherited
Nicotinic receptor ligand binding domain-like0.9711Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Smc hinge domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
beta-glycanases0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
TB module/8-cys domain0Direct
Creatinase/aminopeptidase0Direct
ets domain0Direct
Erythroid transcription factor GATA-10Direct
Zn-finger domain of Sec23/240Direct
Proteasome subunits0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
GLA-domain0Direct
ZZ domain0Direct
Sec1/munc18-like (SM) proteins0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Multidomain cupredoxins0Direct
Fibrinogen coiled-coil and central regions0Direct
Putative glucosidase YicI, domain 30Direct
Apolipoprotein A-I0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Plakin repeat0Direct
GAF domain0Direct
EGF-type module0.005639Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.01301Inherited
Actin/HSP700.01301Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.01301Inherited
Growth factor receptor domain0.02106Inherited
Tropomyosin0.02179Inherited
TNF receptor-like0.02992Inherited
PX domain0.03597Inherited
Spectrin repeat0.04751Inherited
Globins0.05902Inherited
Pyrin domain, PYD0.095Inherited
DNA gyrase/MutL, N-terminal domain0.095Inherited
SMAD domain0.095Inherited
SMAD MH1 domain0.095Inherited
Amylase, catalytic domain0.095Inherited
DNA gyrase/MutL, second domain0.095Inherited
ABC transporter ATPase domain-like0.1029Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1049Inherited
Protein kinases, catalytic subunit0.1079Inherited
Calponin-homology domain, CH-domain0.1187Inherited
RecA protein-like (ATPase-domain)0.1429Inherited
Histone lysine methyltransferases0.1429Inherited
Myosin rod fragments0.1429Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.1517Inherited
Double-stranded RNA-binding domain (dsRBD)0.1517Inherited
NADPH-cytochrome p450 reductase-like0.1517Inherited
MIR domain0.1539Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.1539Inherited
Tetratricopeptide repeat (TPR)0.1864Inherited
PHD domain0.1864Inherited
Cytoplasmic domain of inward rectifier potassium channel0.1993Inherited
Integrin domains0.1993Inherited
DEATH domain, DD0.2026Inherited
C1 set domains (antibody constant domain-like)0.2026Inherited
HMG-box0.2139Inherited
Ras-binding domain, RBD0.2248Inherited
STAT0.2248Inherited
Extracellular domain of cell surface receptors0.2248Inherited
STAT DNA-binding domain0.2248Inherited
Transcription factor STAT-4 N-domain0.2248Inherited
ARID domain0.2248Inherited
DnaQ-like 3'-5' exonuclease0.2248Inherited
MHC antigen-recognition domain0.2346Inherited
Transforming growth factor (TGF)-beta0.2472Inherited
Eukaryotic proteases0.2498Inherited
TNF-like0.2879Inherited
T-box0.2879Inherited
28-residue LRR0.3098Inherited
Fibrinogen C-terminal domain-like0.3098Inherited
Caspase recruitment domain, CARD0.323Inherited
LIM domain0.3381Inherited
VWC domain0.3709Inherited
G proteins0.3877Inherited
Hemopexin-like domain0.4036Inherited
Voltage-gated potassium channels0.485Inherited
MMP N-terminal domain0.5106Inherited
Matrix metalloproteases, catalytic domain0.5106Inherited
Cadherin0.6425Inherited
V set domains (antibody variable domain-like)0.7279Inherited
Calmodulin-like0.7945Inherited
Second domain of FERM0.8606Inherited
Ngr ectodomain-like0.952Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9657Inherited
Nicotinic receptor ligand binding domain-like0.9657Inherited
Intermediate filament protein, coiled coil region0.9659Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SAND domain-like0Direct
RmlC-like cupins0Direct
Saposin0Direct
Tricorn protease domain 20Direct
DPP6 N-terminal domain-like0Direct
GAF domain-like0Direct
Creatinase/aminopeptidase0Direct
TB module/8-cys domain0Direct
Smc hinge domain0Direct
GLA-domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Notch domain0Direct
Plakin repeat0Direct
Fibrinogen coiled-coil and central regions0Direct
Zn-finger domain of Sec23/240Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Apolipoprotein A-I0Direct
Creatinase/prolidase N-terminal domain0Direct
Growth factor receptor domain0.009828Inherited
TNF receptor-like0.01092Inherited
Glycosyl hydrolase domain0.01191Inherited
Actin-like ATPase domain0.01282Inherited
Tropomyosin0.0202Inherited
(Trans)glycosidases0.02631Inherited
cAMP-binding domain-like0.02975Inherited
DEATH domain0.03186Inherited
PX domain0.0334Inherited
DNA/RNA polymerases0.0334Inherited
Spectrin repeat0.04304Inherited
Globin-like0.05509Inherited
Immunoglobulin0.07676Inherited
Protein kinase-like (PK-like)0.08262Inherited
SMAD MH1 domain0.08986Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.09452Inherited
Acyl-CoA dehydrogenase NM domain-like0.09452Inherited
Calponin-homology domain, CH-domain0.1096Inherited
p53-like transcription factors0.1299Inherited
Myosin rod fragments0.1349Inherited
Trypsin-like serine proteases0.1395Inherited
Restriction endonuclease-like0.1458Inherited
Caspase-like0.1458Inherited
MIR domain0.1471Inherited
4-helical cytokines0.1653Inherited
Snake toxin-like0.1653Inherited
Integrin domains0.1898Inherited
HMG-box0.1998Inherited
ARID-like0.2156Inherited
STAT0.2156Inherited
Transcription factor STAT-4 N-domain0.2156Inherited
MHC antigen-recognition domain0.2228Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.263Inherited
FnI-like domain0.2729Inherited
TNF-like0.2729Inherited
Fibrinogen C-terminal domain-like0.297Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.297Inherited
SMAD/FHA domain0.3237Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3576Inherited
Hemopexin-like domain0.3877Inherited
RNI-like0.4525Inherited
PGBD-like0.4958Inherited
Cadherin-like0.5453Inherited
Cystine-knot cytokines0.5595Inherited
TPR-like0.5757Inherited
Voltage-gated potassium channels0.6331Inherited
SH3-domain0.6765Inherited
L domain-like0.6792Inherited
(Phosphotyrosine protein) phosphatases II0.8228Inherited
Second domain of FERM0.8308Inherited
Ribosomal protein S5 domain 2-like0.8308Inherited
FAD/NAD(P)-binding domain0.8681Inherited
Intermediate filament protein, coiled coil region0.9462Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9475Inherited
Nicotinic receptor ligand binding domain-like0.9475Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.007002Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.01191Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.01754Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.02975Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02975Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04702Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05629Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.06523Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.08643Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.08986Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08986Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.08986Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.09452Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.09893Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.1458Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1578Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.1898Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2156Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2156Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2156Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2228Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2228Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.4958Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.9475Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003986Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.007002Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0202Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0334Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0334Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.09893Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1212Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1458Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2156Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2156Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2627Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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