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Phenotypic Abnormality (PA): Abnormality of the spleen

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
+ + 2:   Abnormality of the vasculature [HP:0002597] <13>(35|56) (45|27|18)
+ + 2:   Abnormality of the digestive system [HP:0025031] <6>(67|77) (77|46|25)
+ + 2:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
+ 1:   Abnormality of the abdominal organs [HP:0002012] <6>(27|27) (30|13|4)
+ 1:   Abnormality of the lymphatic system [HP:0100763] <7>(9|19) (15|8|5)
0:   Abnormality of the spleen [HP:0001743] <2>(7|14) (9|4|3)
- 1:   Abnormal spleen morphology [HP:0025408] <11>(7|13) (9|4|3)
- 1:   Abnormal spleen physiology [HP:0025409] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Globin-like0.00005223Direct
TNF receptor-like0.004899Inherited
DEATH domain0.01333Inherited
(Trans)glycosidases0.05518Inherited
Notch domain0.1078Inherited
Fibrinogen C-terminal domain-like0.1078Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Fibrinogen coiled-coil and central regions0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Globins0.00003035Direct
Pyrin domain, PYD0.0002247Direct
Ras-binding domain, RBD0.000981Direct
beta-glycanases0.001485Inherited
28-residue LRR0.002387Inherited
PX domain0.002566Inherited
TNF receptor-like0.01252Inherited
DEATH domain, DD0.04259Inherited
Notch domain0.08686Inherited
Fibrinogen C-terminal domain-like0.08686Inherited
Tetratricopeptide repeat (TPR)0.3124Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Globin-like0.00002349Direct
PX domain0.00226Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00226Inherited
TNF receptor-like0.002974Inherited
DEATH domain0.008793Inherited
(Trans)glycosidases0.04106Inherited
Fibrinogen C-terminal domain-like0.08505Inherited
Notch domain0.08505Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0001854Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.001312Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.006167Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.001312Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08505Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)