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Phenotypic Abnormality (PA): Abnormality of the respiratory system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the respiratory system [HP:0002086] <3>(30|35) (38|24|21)
- 1:   Functional respiratory abnormality [HP:0002795] <27>(10|13) (13|7|4)
- 1:   Abnormal respiratory system morphology [HP:0012252] <5>(20|25) (26|18|17)
- 1:   Neoplasm of the respiratory system [HP:0100606] <4>(1|0) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Saposin0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
Lipoxigenase0Direct
Actin depolymerizing proteins0Direct
p53-like transcription factors0.0001404Direct
SH2 domain0.000166Direct
4-helical cytokines0.01011Inherited
DEATH domain0.02221Inherited
Growth factor receptor domain0.02296Inherited
TB module/8-cys domain0.03539Inherited
Calcium-dependent phosphotriesterase0.07057Inherited
RuvA domain 2-like0.07057Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.127Inherited
Nicotinic receptor ligand binding domain-like0.127Inherited
MHC antigen-recognition domain0.158Inherited
GLA-domain0.1669Inherited
Cystine-knot cytokines0.2061Inherited
EGF/Laminin0.2534Inherited
TNF receptor-like0.2872Inherited
Ubiquitin-like0.3718Inherited
Snake toxin-like0.3909Inherited
Tropomyosin0.4749Inherited
RNA-binding domain, RBD0.4861Inherited
Intermediate filament protein, coiled coil region0.6364Inherited
ABC transporter transmembrane region0.7811Inherited
WD40 repeat-like0.8282Inherited
Voltage-gated potassium channels0.8651Inherited
vWA-like0.9291Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
beta-glycanases0Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
Filamin repeat (rod domain)0Direct
Animal lipoxigenases0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Plakin repeat0Direct
SH2 domain0.000083Direct
Growth factor receptor domain0.0001953Direct
Ras-binding domain, RBD0.01156Inherited
STAT0.01156Inherited
STAT DNA-binding domain0.01156Inherited
Transcription factor STAT-4 N-domain0.01156Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.01156Inherited
TB module/8-cys domain0.02544Inherited
DEATH domain, DD0.02899Inherited
C1 set domains (antibody constant domain-like)0.02899Inherited
VWC domain0.03824Inherited
ZZ domain0.0546Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1019Inherited
Nicotinic receptor ligand binding domain-like0.1019Inherited
Tetratricopeptide repeat (TPR)0.1179Inherited
Laminin-type module0.1232Inherited
MHC antigen-recognition domain0.1295Inherited
GLA-domain0.138Inherited
MIR domain0.138Inherited
Arylsulfatase0.2002Inherited
RecA protein-like (ATPase-domain)0.2002Inherited
Canonical RBD0.3108Inherited
Eukaryotic proteases0.3108Inherited
Tropomyosin0.4334Inherited
ABC transporter ATPase domain-like0.578Inherited
Intermediate filament protein, coiled coil region0.5973Inherited
Integrin A (or I) domain0.7499Inherited
ABC transporter transmembrane region0.7546Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lipoxigenase0Direct
Saposin0Direct
Tricorn protease domain 20Direct
Actin depolymerizing proteins0Direct
Notch domain0Direct
Plakin repeat0Direct
p53-like transcription factors0.00006585Direct
SH2 domain0.00007852Direct
4-helical cytokines0.006521Inherited
STAT0.01147Inherited
Transcription factor STAT-4 N-domain0.01147Inherited
DEATH domain0.01528Inherited
Growth factor receptor domain0.01582Inherited
RCC1/BLIP-II0.01932Inherited
TB module/8-cys domain0.02527Inherited
Adenine nucleotide alpha hydrolases-like0.03778Inherited
RuvA domain 2-like0.05382Inherited
Calcium-dependent phosphotriesterase0.05382Inherited
Immunoglobulin0.0829Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.102Inherited
Nicotinic receptor ligand binding domain-like0.102Inherited
MHC antigen-recognition domain0.1294Inherited
GLA-domain0.1372Inherited
MIR domain0.1372Inherited
Cystine-knot cytokines0.173Inherited
Trypsin-like serine proteases0.215Inherited
EGF/Laminin0.2162Inherited
TNF receptor-like0.2481Inherited
Ubiquitin-like0.3291Inherited
Snake toxin-like0.3477Inherited
Tropomyosin0.431Inherited
RNA-binding domain, RBD0.4424Inherited
Intermediate filament protein, coiled coil region0.5952Inherited
ABC transporter transmembrane region0.745Inherited
WD40 repeat-like0.7948Inherited
Voltage-gated potassium channels0.8336Inherited
vWA-like0.9019Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9602Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01147Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01147Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01147Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02527Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.02527Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.02729Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.07858Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.102Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1294Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1336Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2151Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.2986Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.745Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002124Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01147Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01147Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02527Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02527Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03778Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04794Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.05382Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2926Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3372Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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