SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Upper motor neuron dysfunction

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ + 2:   Abnormality of nervous system physiology [HP:0012638] <26>(101|119) (112|81|39)
+ 1:   Abnormality of central motor function [HP:0011442] <10>(22|26) (30|16|7)
0:   Upper motor neuron dysfunction [HP:0002493] <4>(9|15) (13|8|4)
- 1:   Abnormal pyramidal sign [HP:0007256] <5>(2|2) (2|1|0)
- 1:   Hypertonia [HP:0001276] <3>(4|9) (5|5|2)
- 1:   Weakness due to upper motor neuron dysfunction [HP:0010549] <3>(1|4) (4|2|2)
- 1:   Dysfunction of lateral corticospinal tracts [HP:0007299](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ribonuclease PH domain 2-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
ADC-like0Direct
Periplasmic binding protein-like II0.00003074Direct
Periplasmic binding protein-like I0.0003059Direct
Translation proteins0.0008355Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02573Inherited
Cysteine proteinases0.521Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ribonuclease PH domain 1-like0Direct
Ribonuclease PH domain 2-like0Direct
IF2B-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ferredoxin domains from multidomain proteins0Direct
UBA domain0Direct
Phosphate binding protein-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Elongation factors0.0008948Direct
L-arabinose binding protein-like0.0009993Direct
DNA gyrase/MutL, N-terminal domain0.005967Inherited
DNA gyrase/MutL, second domain0.005967Inherited
Extended AAA-ATPase domain0.1006Inherited
MHC antigen-recognition domain0.4297Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
ADC-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Ribonuclease PH domain 2-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Periplasmic binding protein-like II0.00001355Direct
Periplasmic binding protein-like I0.000151Direct
Translation proteins0.0004378Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.01783Inherited
Class II aaRS and biotin synthetases0.01871Inherited
4Fe-4S ferredoxins0.01929Inherited
HAD-like0.2982Inherited
MHC antigen-recognition domain0.4334Inherited
Cysteine proteinases0.4766Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0000505Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.006592Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.4334Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2178Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3483Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)