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Phenotypic Abnormality (PA): Abnormal circulating lipid concentration

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(75|82) (79|40|16)
+ 1:   Abnormal circulating metabolite concentration [HP:0032180] <12>(30|31) (31|14|4)
0:   Abnormal circulating lipid concentration [HP:0003119] <6>(6|5) (6|2|1)
- 1:   Abnormal circulating cholesterol concentration [HP:0003107] <8>(2|1) (2|0|0)
- 1:   Abnormal circulating fatty-acid concentration [HP:0004359] <6>(3|2) (3|1|0)
- 1:   Hyperlipidemia [HP:0003077] <2>(2|1) (2|0|1)
- 1:   Abnormal circulating phospholipid concentration [HP:0040176] <1>(0|0) (0|0|0)
- 1:   Hypolipidemia [HP:0045014] <1>(0|0) (0|0|0)
- 1:   Hyperapobetalipoproteinemia [HP:0008158](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Apolipoprotein A-I0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0003558Direct
Acyl-CoA dehydrogenase NM domain-like0.0003558Direct
alpha/beta-Hydrolases0.001099Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01544Inherited
RING/U-box0.2703Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Apolipoprotein A-I0Direct
Pancreatic lipase, N-terminal domain0.00006928Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0006682Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0006682Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Apolipoprotein A-I0Direct
Acyl-CoA dehydrogenase NM domain-like0.0001762Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0001762Direct
alpha/beta-Hydrolases0.0005868Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01028Inherited
RING/U-box0.2322Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.0001762Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05967Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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