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Phenotypic Abnormality (PA): Limb muscle weakness

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the musculature [HP:0003011] <3>(62|74) (69|31|7)
+ + 2:   Abnormality of limbs [HP:0040064] <8>(57|64) (59|32|25)
+ + 2:   Abnormal muscle physiology [HP:0011804] <12>(43|55) (52|22|4)
+ + 2:   Abnormal skeletal muscle morphology [HP:0011805] <38>(30|34) (32|13|3)
+ 1:   Muscle weakness [HP:0001324] <22>(14|14) (15|4|0)
+ 1:   Abnormality of the musculature of the limbs [HP:0009127] <10>(12|8) (14|4|2)
0:   Limb muscle weakness [HP:0003690] <4>(5|4) (6|1|0)
- 1:   Upper limb muscle weakness [HP:0003484] <2>(2|2) (2|1|0)
- 1:   Lower limb muscle weakness [HP:0007340] <1>(1|1) (2|0|0)
- 1:   Proximal muscle weakness in lower limbs [HP:0008994] <1>(0|0) (0|0|0)
- 1:   Foot dorsiflexor weakness [HP:0009027](1|0) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
HSP20-like chaperones0.00004962Direct
S15/NS1 RNA-binding domain0.0001553Direct
Nicotinic receptor ligand binding domain-like0.003228Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.003228Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02285Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
a tRNA synthase domain0.00008208Direct
Nicotinic receptor ligand binding domain-like0.001947Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.001947Inherited
Myosin rod fragments0.04607Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
HSP20-like chaperones0.00002319Direct
S15/NS1 RNA-binding domain0.0000758Direct
Nicotinic receptor ligand binding domain-like0.00192Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.00192Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.01587Inherited
Myosin rod fragments0.04483Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.00192Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)