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Phenotypic Abnormality (PA): Abnormality of complement system

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
+ + 2:   Abnormality of immune system physiology [HP:0010978] <14>(29|37) (31|22|11)
+ 1:   Abnormality of humoral immunity [HP:0005368] <4>(13|15) (13|9|5)
0:   Abnormality of complement system [HP:0005339] <4>(10|10) (10|7|5)
- 1:   Complement deficiency [HP:0004431] <8>(6|6) (6|2|1)
- 1:   Abnormal total hemolytic complement activity [HP:0031904] <2>(0|0) (0|0|0)
- 1:   Abnormality of the alternative complement pathway [HP:0005482] <2>(0|0) (0|0|0)
- 1:   Reduced hemolytic complement activity [HP:0025434](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Alpha-macroglobulin receptor domain0.0000000841Direct
TIMP-like0.0000001854Direct
Complement control module/SCR domain0.000005457Direct
TSP-1 type 1 repeat0.00003418Direct
LDL receptor-like module0.0000426Direct
Spermadhesin, CUB domain0.0001969Direct
Trypsin-like serine proteases0.0001976Direct
Terpenoid cyclases/Protein prenyltransferases0.001076Inherited
TNF-like0.07386Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Netrin-like domain (NTR/C345C module)0Direct
Anaphylotoxins (complement system)0Direct
Complement components0.00000006785Direct
Alpha-macroglobulin receptor domain0.00000006785Direct
Complement control module/SCR domain0.000006185Direct
TSP-1 type 1 repeat0.00003142Direct
LDL receptor-like module0.00003594Direct
Spermadhesin, CUB domain0.0001563Direct
Eukaryotic proteases0.000186Direct
TNF-like0.07304Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Alpha-macroglobulin receptor domain0.00000003259Direct
TIMP-like0.00000007224Direct
Complement control module/SCR domain0.000002265Direct
TSP-1 type 1 repeat0.00001512Direct
LDL receptor-like module0.000019Direct
Spermadhesin, CUB domain0.00009438Direct
Trypsin-like serine proteases0.00009481Direct
Terpenoid cyclases/Protein prenyltransferases0.0005746Direct
TNF-like0.05653Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
82895,57424
  • 82895 - TSP-1 type 1 repeat
  • 57424 - LDL receptor-like module
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.00000007184Direct
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.00000007184Direct
    49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0.0000003486Direct
    57196,49854
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.000001017Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.000002265Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.00000007184Direct
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.00000007184Direct
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.00000007184Direct
    49854,57196,49854
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.0000003486Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.002385Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)