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Phenotypic Abnormality (PA): Neoplasm by anatomical site

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Neoplasm [HP:0002664] <2>(20|21) (23|8|3)
0:   Neoplasm by anatomical site [HP:0011793] <24>(18|19) (20|7|2)
- 1:   Neoplasm of the skin [HP:0008069] <29>(4|5) (4|3|1)
- 1:   Neoplasm of the gastrointestinal tract [HP:0007378] <16>(6|5) (6|4|0)
- 1:   Neoplasm of the skeletal system [HP:0010622] <10>(1|2) (2|1|0)
- 1:   Hematological neoplasm [HP:0004377] <7>(2|2) (2|1|0)
- 1:   Neoplasm of the endocrine system [HP:0100568] <6>(6|5) (6|3|0)
- 1:   Neoplasm of the heart [HP:0100544] <6>(0|0) (0|0|0)
- 1:   Neoplasm of the eye [HP:0100012] <5>(0|0) (0|0|0)
- 1:   Neoplasm of the oral cavity [HP:0100649] <5>(0|0) (0|0|0)
- 1:   Malignant mesothelioma [HP:0100001] <4>(0|0) (0|0|0)
- 1:   Neoplasm of head and neck [HP:0012288] <4>(0|0) (0|0|0)
- 1:   Neoplasm of the breast [HP:0100013] <4>(2|3) (2|0|0)
- 1:   Neoplasm of the genitourinary tract [HP:0007379] <4>(7|6) (9|2|1)
- 1:   Neoplasm of the pancreas [HP:0002894] <4>(2|2) (3|1|0)
- 1:   Neoplasm of the respiratory system [HP:0100606] <4>(1|0) (1|0|0)
- 1:   Neoplasm of the ear [HP:0012780] <3>(0|0) (0|0|0)
- 1:   Soft tissue neoplasm [HP:0031459] <3>(0|0) (0|0|0)
- 1:   Neoplasm of striated muscle [HP:0009728] <2>(0|0) (0|0|0)
- 1:   Neoplasm of the nervous system [HP:0004375] <2>(3|6) (3|2|0)
- 1:   Vascular neoplasm [HP:0100742] <2>(2|1) (2|0|0)
- 1:   Neoplasm of fatty tissue [HP:0200013] <1>(0|0) (0|0|0)
- 1:   Neoplasm of the nail [HP:0100826] <1>(0|0) (0|0|0)
- 1:   Neoplasm of the thymus [HP:0100521] <1>(0|0) (0|0|0)
- 1:   Neoplasm of the lip [HP:0100604](0|0) (0|0|0)
- 1:   Retroperitoneal chemodectomas [HP:0006729](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DNA-glycosylase0Direct
TNF receptor-like0.008432Inherited
DNA repair protein MutS, domain III0.01187Inherited
Sema domain0.01764Inherited
Ribosomal protein S5 domain 2-like0.02039Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03Inherited
Ribonuclease H-like0.03115Inherited
BRCT domain0.06666Inherited
Plexin repeat0.087Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1051Inherited
Nuclear receptor ligand-binding domain0.2269Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2281Inherited
Intermediate filament protein, coiled coil region0.2367Inherited
(Phosphotyrosine protein) phosphatases II0.3074Inherited
DEATH domain0.6729Inherited
Ubiquitin-like0.7174Inherited
Protein kinase-like (PK-like)1Inherited
Snake toxin-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA gyrase/MutL, N-terminal domain0Direct
DNA gyrase/MutL, second domain0Direct
DIX domain0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.008676Inherited
DNA repair protein MutS, domain III0.008676Inherited
Sema domain0.01381Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.03558Inherited
Ras-binding domain, RBD0.05198Inherited
POU-specific domain0.05198Inherited
Plexin repeat0.07654Inherited
FHA domain0.08272Inherited
RING finger domain, C3HC40.09647Inherited
DEATH domain, DD0.1002Inherited
Laminin-type module0.1813Inherited
Nuclear receptor ligand-binding domain0.2146Inherited
Intermediate filament protein, coiled coil region0.2272Inherited
ABC transporter ATPase domain-like0.7591Inherited
RecA protein-like (ATPase-domain)0.8162Inherited
Protein kinases, catalytic subunit1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DNA-glycosylase0Direct
TNF receptor-like0.005372Inherited
DNA repair protein MutS, domain III0.007736Inherited
Sema domain0.01187Inherited
Ribosomal protein S5 domain 2-like0.01392Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02106Inherited
Ribonuclease H-like0.02195Inherited
BRCT domain0.05049Inherited
Plexin repeat0.06748Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.0829Inherited
lambda repressor-like DNA-binding domains0.1521Inherited
Nuclear receptor ligand-binding domain0.192Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1932Inherited
Intermediate filament protein, coiled coil region0.201Inherited
(Phosphotyrosine protein) phosphatases II0.2674Inherited
RING/U-box0.5144Inherited
DEATH domain0.633Inherited
Ubiquitin-like0.6789Inherited
Protein kinase-like (PK-like)0.9899Inherited
Snake toxin-like0.9998Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.004087Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.007736Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.007736Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.007736Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.01187Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3039Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1699Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1954Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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