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Phenotypic Abnormality (PA): Abnormal respiratory system morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the respiratory system [HP:0002086] <3>(30|35) (38|24|21)
0:   Abnormal respiratory system morphology [HP:0012252] <5>(20|25) (26|18|17)
- 1:   Abnormal lung morphology [HP:0002088] <28>(11|18) (18|11|7)
- 1:   Abnormal sputum [HP:0032016] <3>(3|2) (4|1|0)
- 1:   Abnormal pulmonary situs morphology [HP:0011615] <2>(0|0) (0|0|0)
- 1:   Abnormal respiratory epithelium morphology [HP:0012253] <2>(0|0) (0|0|0)
- 1:   Abnormality of the upper respiratory tract [HP:0002087] <2>(8|9) (8|5|8)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Saposin0Direct
Tricorn protease domain 20Direct
DEATH domain0.004128Inherited
TB module/8-cys domain0.007606Inherited
Calcium-dependent phosphotriesterase0.02217Inherited
RuvA domain 2-like0.02217Inherited
Growth factor receptor domain0.05529Inherited
TNF receptor-like0.07133Inherited
EGF/Laminin0.09533Inherited
Ubiquitin-like0.1822Inherited
MHC antigen-recognition domain0.1978Inherited
Tropomyosin0.2182Inherited
Snake toxin-like0.2657Inherited
RNA-binding domain, RBD0.2751Inherited
WD40 repeat-like0.4226Inherited
Cystine-knot cytokines0.4557Inherited
4-helical cytokines0.5123Inherited
ABC transporter transmembrane region0.626Inherited
Intermediate filament protein, coiled coil region0.7246Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
beta-glycanases0Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Ras-binding domain, RBD0.001517Inherited
STAT0.001517Inherited
STAT DNA-binding domain0.001517Inherited
Transcription factor STAT-4 N-domain0.001517Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.001517Inherited
DEATH domain, DD0.001708Inherited
TB module/8-cys domain0.005034Inherited
VWC domain0.00628Inherited
Laminin-type module0.01839Inherited
Arylsulfatase0.05042Inherited
C1 set domains (antibody constant domain-like)0.07305Inherited
Tetratricopeptide repeat (TPR)0.1213Inherited
MHC antigen-recognition domain0.1747Inherited
Tropomyosin0.1898Inherited
Canonical RBD0.1937Inherited
Eukaryotic proteases0.1937Inherited
RecA protein-like (ATPase-domain)0.2326Inherited
Filamin repeat (rod domain)0.3109Inherited
ABC transporter transmembrane region0.4318Inherited
ABC transporter ATPase domain-like0.4905Inherited
Intermediate filament protein, coiled coil region0.7097Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Saposin0Direct
Tricorn protease domain 20Direct
Notch domain0Direct
STAT0.001408Inherited
Transcription factor STAT-4 N-domain0.001408Inherited
RCC1/BLIP-II0.001959Inherited
DEATH domain0.002467Inherited
TB module/8-cys domain0.004798Inherited
RuvA domain 2-like0.01525Inherited
Calcium-dependent phosphotriesterase0.01525Inherited
Growth factor receptor domain0.04116Inherited
TNF receptor-like0.05446Inherited
EGF/Laminin0.07459Inherited
Ubiquitin-like0.1508Inherited
MHC antigen-recognition domain0.1653Inherited
Tropomyosin0.184Inherited
Snake toxin-like0.2278Inherited
RNA-binding domain, RBD0.237Inherited
Immunoglobulin0.2901Inherited
Trypsin-like serine proteases0.3665Inherited
WD40 repeat-like0.379Inherited
Cystine-knot cytokines0.4119Inherited
4-helical cytokines0.4679Inherited
ABC transporter transmembrane region0.5847Inherited
Intermediate filament protein, coiled coil region0.6863Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8666Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.001408Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001408Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001408Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.004798Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.004798Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.007774Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01417Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.04339Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0906Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1653Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.2995Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.5847Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001408Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001408Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004798Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.004798Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00493Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.005968Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.01525Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04442Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.2995Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3623Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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