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Phenotypic Abnormality (PA): Abnormal inflammatory response

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
+ 1:   Abnormality of immune system physiology [HP:0010978] <14>(29|37) (31|22|11)
0:   Abnormal inflammatory response [HP:0012647] <2>(17|20) (18|11|3)
- 1:   Increased inflammatory response [HP:0012649] <27>(15|18) (16|9|3)
- 1:   Decreased inflammatory response [HP:0012648](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
DNA/RNA polymerases0.0002932Direct
DEATH domain0.006875Inherited
STAT0.01404Inherited
Transcription factor STAT-4 N-domain0.01404Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.03029Inherited
MHC antigen-recognition domain0.1102Inherited
SH2 domain0.1609Inherited
Trypsin-like serine proteases0.1916Inherited
TNF-like0.2162Inherited
Cysteine-rich domain0.2314Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.304Inherited
Immunoglobulin0.406Inherited
RNI-like0.4337Inherited
4-helical cytokines0.4594Inherited
TNF receptor-like0.5732Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.7859Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Netrin-like domain (NTR/C345C module)0Direct
Anaphylotoxins (complement system)0Direct
Proteasome subunits0Direct
Pyrin domain, PYD0.002972Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01064Inherited
Transcription factor STAT-4 N-domain0.01083Inherited
STAT0.01083Inherited
STAT DNA-binding domain0.01083Inherited
Caspase recruitment domain, CARD0.03143Inherited
C1 set domains (antibody constant domain-like)0.04831Inherited
Noncollagenous (NC1) domain of collagen IV0.0619Inherited
PHD domain0.08096Inherited
MHC antigen-recognition domain0.1039Inherited
SH2 domain0.1625Inherited
28-residue LRR0.1716Inherited
DEATH domain, DD0.2133Inherited
TNF-like0.2133Inherited
PLC-like (P variant)0.223Inherited
Eukaryotic proteases0.2299Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2831Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
DNA/RNA polymerases0.0001445Direct
DEATH domain0.00431Inherited
STAT0.0093Inherited
Transcription factor STAT-4 N-domain0.0093Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.02128Inherited
MHC antigen-recognition domain0.08701Inherited
SH2 domain0.1319Inherited
Trypsin-like serine proteases0.1596Inherited
TNF-like0.1822Inherited
Cysteine-rich domain0.1962Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2641Inherited
Snake toxin-like0.3355Inherited
Immunoglobulin0.3627Inherited
RNI-like0.3899Inherited
4-helical cytokines0.4157Inherited
TNF receptor-like0.5303Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.75Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002489Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0093Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0093Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0093Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.009344Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.08701Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.1301Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.6105Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0093Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0093Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3355Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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