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Phenotypic Abnormality (PA): Neurodevelopmental delay

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ + 2:   Abnormality of nervous system physiology [HP:0012638] <26>(101|119) (112|81|39)
+ 1:   Neurodevelopmental abnormality [HP:0012759] <5>(36|53) (39|26|12)
0:   Neurodevelopmental delay [HP:0012758] <4>(17|30) (18|10|2)
- 1:   Global developmental delay [HP:0001263] <4>(10|17) (11|3|0)
- 1:   Delayed speech and language development [HP:0000750] <3>(1|4) (1|1|0)
- 1:   Motor delay [HP:0001270] <2>(1|1) (1|0|0)
- 1:   Delayed social development [HP:0012434](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
L-aspartase-like0Direct
Helical domain of Sec23/240Direct
L27 domain0Direct
PP2C-like0Direct
NTF2-like0Direct
Zn-finger domain of Sec23/240Direct
CCCH zinc finger0Direct
Ribonuclease PH domain 2-like0Direct
RuvA domain 2-like0Direct
Hect, E3 ligase catalytic domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Lamin A/C globular tail domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00088Direct
SET domain0.003258Inherited
ARID-like0.02869Inherited
Nucleotidylyl transferase0.05861Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
L27 domain0Direct
Ribonuclease PH domain 1-like0Direct
Trunk domain of Sec23/240Direct
Anticodon-binding domain0Direct
Zn-finger domain of Sec23/240Direct
Ribonuclease PH domain 2-like0Direct
Lamin A/C globular tail domain0Direct
Protein serine/threonine phosphatase0Direct
CCCH zinc finger0Direct
beta-sandwich domain of Sec23/240Direct
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A0Direct
N-acetyl transferase, NAT0Direct
Ferredoxin domains from multidomain proteins0Direct
Histone lysine methyltransferases0Direct
CUT domain0Direct
SWIRM domain0Direct
L-aspartase/fumarase0Direct
PP2C-like0Direct
Glycosyl transferases group 10Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Hect, E3 ligase catalytic domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0007942Direct
Phosphate binding protein-like0.001766Inherited
ARID domain0.01742Inherited
L-arabinose binding protein-like0.02646Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.06565Inherited
PHD domain0.1193Inherited
HMG-box0.1601Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
L27 domain0Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
CCCH zinc finger0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
NTF2-like0Direct
L-aspartase-like0Direct
PP2C-like0Direct
Lamin A/C globular tail domain0Direct
Ribonuclease PH domain 2-like0Direct
RuvA domain 2-like0Direct
Hect, E3 ligase catalytic domain0Direct
Zn-finger domain of Sec23/240Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0004628Direct
SET domain0.001903Inherited
ARID-like0.02006Inherited
Nucleotidylyl transferase0.04388Inherited
HMG-box0.1807Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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