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Phenotypic Abnormality (PA): Abnormality of the digestive system

(show info)

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the digestive system [HP:0025031] <6>(67|77) (77|46|25)
- 1:   Abnormality of abdomen morphology [HP:0001438] <7>(6|10) (8|5|2)
- 1:   Abnormality of the abdominal organs [HP:0002012] <6>(27|27) (30|13|4)
- 1:   Abnormality of digestive system physiology [HP:0025032] <5>(29|32) (37|13|1)
- 1:   Abnormality of the abdominal wall [HP:0004298] <5>(3|5) (3|4|7)
- 1:   Abnormality of the gastrointestinal tract [HP:0011024] <3>(24|27) (28|13|4)
- 1:   Abnormality of digestive system morphology [HP:0025033] <2>(13|19) (17|8|4)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
LuxS/MPP-like metallohydrolase0Direct
Notch domain0Direct
Restriction endonuclease-like0Direct
Galactose mutarotase-like0Direct
Glycosyl hydrolase domain0Direct
Plakin repeat0Direct
SAND domain-like0Direct
Zn-finger domain of Sec23/240Direct
PA domain0Direct
Ribonuclease PH domain 2-like0Direct
BPTI-like0Direct
Tricorn protease domain 20Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Sec1/munc18-like (SM) proteins0Direct
DHS-like NAD/FAD-binding domain0Direct
dsRNA-binding domain-like0Direct
ADC-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Actin depolymerizing proteins0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Lamin A/C globular tail domain0Direct
Actin-like ATPase domain0.001004Inherited
(Trans)glycosidases0.00938Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.0112Inherited
Acyl-CoA dehydrogenase NM domain-like0.0112Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0112Inherited
beta-sandwich domain of Sec23/240.04139Inherited
Ran binding protein zinc finger-like0.04139Inherited
Ribosomal protein S5 domain 2-like0.04976Inherited
Adenine nucleotide alpha hydrolases-like0.06241Inherited
Globin-like0.09397Inherited
ValRS/IleRS/LeuRS editing domain0.09397Inherited
Protein kinase-like (PK-like)0.09733Inherited
Integrin domains0.1154Inherited
ABC transporter transmembrane region0.1197Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.1207Inherited
CalX-like0.141Inherited
GroEL equatorial domain-like0.141Inherited
DEATH domain0.1466Inherited
"Winged helix" DNA-binding domain0.1959Inherited
Complement control module/SCR domain0.2027Inherited
DNA repair protein MutS, domain III0.2091Inherited
4Fe-4S ferredoxins0.2091Inherited
SET domain0.2198Inherited
RNI-like0.2719Inherited
Nucleotidylyl transferase0.2744Inherited
BRCT domain0.2816Inherited
MHC antigen-recognition domain0.329Inherited
alpha/beta-Hydrolases0.3404Inherited
TNF receptor-like0.3678Inherited
FnI-like domain0.4006Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.4108Inherited
Fibrinogen C-terminal domain-like0.4108Inherited
Snake toxin-like0.4475Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.4651Inherited
TPR-like0.5606Inherited
SpoIIaa-like0.5807Inherited
SH3-domain0.7044Inherited
Immunoglobulin0.7437Inherited
L domain-like0.7667Inherited
Intermediate filament protein, coiled coil region0.7931Inherited
WD40 repeat-like0.9206Inherited
Homeodomain-like0.9541Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9911Inherited
Cadherin-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
MPP-like0Direct
Smc hinge domain0Direct
beta-glycanases0Direct
Ribonuclease PH domain 1-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Zn-finger domain of Sec23/240Direct
Ribonuclease PH domain 2-like0Direct
Lamin A/C globular tail domain0Direct
P4 origin-binding domain-like0Direct
Proteasome subunits0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
N-acetyl transferase, NAT0Direct
Sec1/munc18-like (SM) proteins0Direct
YicI catalytic domain-like0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Fibrinogen coiled-coil and central regions0Direct
DIX domain0Direct
Small Kunitz-type inhibitors & BPTI-like toxins0Direct
Putative glucosidase YicI, domain 30Direct
Glycosyl transferases group 10Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Plakin repeat0Direct
DNA polymerase I0Direct
Interleukin-1 (IL-1)0Direct
FAD/NAD-linked reductases, N-terminal and central domains0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.01285Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.02051Inherited
Actin/HSP700.02051Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.02051Inherited
Ran binding protein zinc finger-like0.0323Inherited
Transforming growth factor (TGF)-beta0.04084Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.04084Inherited
PX domain0.05055Inherited
28-residue LRR0.0683Inherited
Histone lysine methyltransferases0.0683Inherited
G proteins0.07011Inherited
Extended AAA-ATPase domain0.07605Inherited
Ras-binding domain, RBD0.0783Inherited
Globins0.0783Inherited
ValRS/IleRS/LeuRS editing domain0.0783Inherited
DnaQ-like 3'-5' exonuclease0.0783Inherited
Tetratricopeptide repeat (TPR)0.09078Inherited
Integrin domains0.09778Inherited
Eukaryotic proteases0.1076Inherited
Pyrin domain, PYD0.1197Inherited
DNA gyrase/MutL, N-terminal domain0.1197Inherited
DNA gyrase/MutL, second domain0.1197Inherited
CalX-beta domain0.1197Inherited
DEATH domain, DD0.1371Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.1827Inherited
DNA repair protein MutS, domain III0.1827Inherited
Complement control module/SCR domain0.1827Inherited
RecA protein-like (ATPase-domain)0.1909Inherited
VWC domain0.1958Inherited
ABC transporter transmembrane region0.2345Inherited
BC ATP-binding domain-like0.2728Inherited
Nitrogenase iron protein-like0.2728Inherited
BC N-terminal domain-like0.2728Inherited
C1 set domains (antibody constant domain-like)0.2728Inherited
MHC antigen-recognition domain0.3015Inherited
Laminin-type module0.341Inherited
EGF-type module0.3607Inherited
Anti-sigma factor antagonist SpoIIaa0.3763Inherited
SNARE fusion complex0.3763Inherited
Fibrinogen C-terminal domain-like0.3835Inherited
TNF receptor-like0.5086Inherited
KRAB domain (Kruppel-associated box)0.5523Inherited
Laminin G-like module0.5559Inherited
SH3-domain0.7383Inherited
Intermediate filament protein, coiled coil region0.7849Inherited
Homeodomain0.9656Inherited
Cadherin0.9942Inherited
Ngr ectodomain-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SAND domain-like0Direct
LuxS/MPP-like metallohydrolase0Direct
Galactose mutarotase-like0Direct
Restriction endonuclease-like0Direct
ADC-like0Direct
DHS-like NAD/FAD-binding domain0Direct
dsRNA-binding domain-like0Direct
Tricorn protease domain 20Direct
Actin depolymerizing proteins0Direct
BPTI-like0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Smc hinge domain0Direct
Glycosyl hydrolase domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Lamin A/C globular tail domain0Direct
Ribonuclease PH domain 2-like0Direct
Notch domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
PA domain0Direct
Plakin repeat0Direct
Fibrinogen coiled-coil and central regions0Direct
Zn-finger domain of Sec23/240Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Actin-like ATPase domain0.0005353Direct
(Trans)glycosidases0.006017Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.007253Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.007253Inherited
Acyl-CoA dehydrogenase NM domain-like0.007253Inherited
Ran binding protein zinc finger-like0.02987Inherited
beta-sandwich domain of Sec23/240.02987Inherited
Ribosomal protein S5 domain 2-like0.03668Inherited
Adenine nucleotide alpha hydrolases-like0.04706Inherited
PX domain0.04706Inherited
DNA/RNA polymerases0.04706Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.04706Inherited
Trypsin-like serine proteases0.05732Inherited
Globin-like0.07337Inherited
ValRS/IleRS/LeuRS editing domain0.07337Inherited
Protein kinase-like (PK-like)0.07625Inherited
Integrin domains0.09155Inherited
ABC transporter transmembrane region0.09534Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.0963Inherited
GroEL equatorial domain-like0.1145Inherited
CalX-like0.1145Inherited
DEATH domain0.1195Inherited
"Winged helix" DNA-binding domain0.1636Inherited
Complement control module/SCR domain0.1699Inherited
4Fe-4S ferredoxins0.1757Inherited
DNA repair protein MutS, domain III0.1757Inherited
Calcium-dependent phosphotriesterase0.1757Inherited
SET domain0.1856Inherited
RNI-like0.2338Inherited
Nucleotidylyl transferase0.2361Inherited
BRCT domain0.2432Inherited
MHC antigen-recognition domain0.288Inherited
alpha/beta-Hydrolases0.2991Inherited
TNF receptor-like0.3251Inherited
FnI-like domain0.3573Inherited
SNARE fusion complex0.3638Inherited
Class II aaRS and biotin synthetases0.3669Inherited
Fibrinogen C-terminal domain-like0.3674Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.3674Inherited
4-helical cytokines0.4038Inherited
Snake toxin-like0.4038Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.4212Inherited
TPR-like0.5171Inherited
SpoIIaa-like0.5377Inherited
KRAB domain (Kruppel-associated box)0.5377Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.5696Inherited
SH3-domain0.6655Inherited
Immunoglobulin0.7062Inherited
L domain-like0.7298Inherited
Intermediate filament protein, coiled coil region0.7578Inherited
WD40 repeat-like0.8928Inherited
Homeodomain-like0.929Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9697Inherited
Cadherin-like0.9843Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    50156,50044
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.001554Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.007253Inherited
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0.07337Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.09189Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.09534Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1145Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.1145Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.1757Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.1757Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1757Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.1757Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1804Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2626Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.288Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.288Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.321Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.4334Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.5158Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.6893Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.9771Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    50156,50044,52540
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.06292Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1757Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1757Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.288Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.566Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.8437Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.9771Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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