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Phenotypic Abnormality (PA): Abnormal oral morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Phenotypic abnormality [HP:0000118] <25>
+ + + + 4:   Abnormality of head or neck [HP:0000152] <2>(86|104) (97|58|38)
+ + + 3:   Abnormality of the head [HP:0000234] <6>(85|102) (96|57|38)
+ + 2:   Abnormality of the face [HP:0000271] <14>(70|85) (82|46|31)
+ 1:   Abnormality of the mouth [HP:0000153] <2>(37|57) (46|32|22)
0:   Abnormal oral morphology [HP:0031816] <6>(35|53) (44|30|21)
- 1:   Abnormal oral cavity morphology [HP:0000163] <14>(28|43) (36|21|15)
- 1:   Abnormal mandible condylar process morphology [HP:3000077] <1>(0|0) (0|0|0)
- 1:   Abnormal mandible coronoid process morphology [HP:3000078](0|0) (0|0|0)
- 1:   Abnormality of inferior alveolar artery [HP:3000054](0|0) (0|0|0)
- 1:   Abnormality of mandibular symphysis [HP:3000079](0|0) (0|0|0)
- 1:   Pierre-Robin sequence [HP:0000201](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
Helical domain of Sec23/240Direct
TB module/8-cys domain0Direct
Integrin beta tail domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Plakin repeat0Direct
Zn-finger domain of Sec23/240Direct
Tricorn protease domain 20Direct
CalX-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Actin depolymerizing proteins0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Tudor/PWWP/MBT0.0002045Direct
Hect, E3 ligase catalytic domain0.001528Inherited
HMG-box0.007277Inherited
ARID-like0.02607Inherited
Bromodomain0.02788Inherited
Notch domain0.0916Inherited
BRK domain-like0.0916Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0916Inherited
RNI-like0.1063Inherited
MHC antigen-recognition domain0.2167Inherited
Fibrinogen C-terminal domain-like0.3053Inherited
SMAD/FHA domain0.3079Inherited
Transcription factor STAT-4 N-domain0.3241Inherited
STAT0.3241Inherited
Homeodomain-like0.3299Inherited
MIR domain0.4434Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4451Inherited
DEATH domain0.4546Inherited
4-helical cytokines0.4825Inherited
Ubiquitin-like0.4829Inherited
Immunoglobulin0.7289Inherited
Intermediate filament protein, coiled coil region0.8541Inherited
Trypsin-like serine proteases0.9511Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin reductase FAD-binding domain-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
Smc hinge domain0Direct
TB module/8-cys domain0Direct
Trunk domain of Sec23/240Direct
Integrin beta tail domain0Direct
Zn-finger domain of Sec23/240Direct
Protein serine/threonine phosphatase0Direct
Histone deacetylase, HDAC0Direct
beta-sandwich domain of Sec23/240Direct
Clathrin adaptor core protein0Direct
Integrin beta EGF-like domains0Direct
Fibrinogen coiled-coil and central regions0Direct
PWWP domain0Direct
Glycosyl transferases group 10Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Plakin repeat0Direct
Interleukin-1 (IL-1)0Direct
CalX-beta domain0Direct
Hect, E3 ligase catalytic domain0.0009523Direct
PHD domain0.003594Inherited
HMG-box0.005187Inherited
PX domain0.009387Inherited
Histone lysine methyltransferases0.009443Inherited
ARID domain0.01922Inherited
Bromodomain0.02125Inherited
Fibroblast growth factors (FGF)0.02485Inherited
Laminin-type module0.03037Inherited
SPRY domain0.03827Inherited
Pyrin domain, PYD0.03827Inherited
VWC domain0.05959Inherited
Notch domain0.07509Inherited
beta-glycanases0.07509Inherited
DIX domain0.07509Inherited
BRK domain-like0.07509Inherited
RecA protein-like (ATPase-domain)0.1264Inherited
28-residue LRR0.1264Inherited
Homeodomain0.1746Inherited
PDZ domain0.1747Inherited
T-box0.185Inherited
GLA-domain0.1892Inherited
MHC antigen-recognition domain0.1919Inherited
Fibrinogen C-terminal domain-like0.2757Inherited
STAT0.2928Inherited
STAT DNA-binding domain0.2928Inherited
Clathrin coat assembly domain0.2928Inherited
Transcription factor STAT-4 N-domain0.2928Inherited
MIR domain0.4121Inherited
C1 set domains (antibody constant domain-like)0.7067Inherited
PLC-like (P variant)0.7383Inherited
Intermediate filament protein, coiled coil region0.8401Inherited
Eukaryotic proteases0.9035Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Helical domain of Sec23/240Direct
Integrin beta tail domain0Direct
Tricorn protease domain 20Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
TB module/8-cys domain0Direct
Actin depolymerizing proteins0Direct
Smc hinge domain0Direct
Plakin repeat0Direct
Fibrinogen coiled-coil and central regions0Direct
Zn-finger domain of Sec23/240Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
CalX-like0Direct
Tudor/PWWP/MBT0.0000983Direct
Hect, E3 ligase catalytic domain0.0008371Direct
Actin-like ATPase domain0.0009388Direct
Cytokine0.003645Inherited
HMG-box0.004578Inherited
PX domain0.008729Inherited
ARID-like0.01807Inherited
Bromodomain0.01948Inherited
EGF/Laminin0.02948Inherited
Multidrug efflux transporter AcrB transmembrane domain0.03608Inherited
SET domain0.05613Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.07137Inherited
Notch domain0.07137Inherited
BRK domain-like0.07137Inherited
RNI-like0.08382Inherited
DPP6 N-terminal domain-like0.1704Inherited
GLA-domain0.181Inherited
MHC antigen-recognition domain0.1826Inherited
Glycosyl hydrolase domain0.184Inherited
Fibrinogen C-terminal domain-like0.2653Inherited
SMAD/FHA domain0.2678Inherited
STAT0.2833Inherited
Transcription factor STAT-4 N-domain0.2833Inherited
Homeodomain-like0.2888Inherited
MIR domain0.3996Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4013Inherited
DEATH domain0.411Inherited
4-helical cytokines0.4388Inherited
Ubiquitin-like0.4392Inherited
Immunoglobulin0.6907Inherited
Intermediate filament protein, coiled coil region0.8219Inherited
Trypsin-like serine proteases0.9256Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.01807Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04732Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.06826Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.07137Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1704Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1826Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.184Inherited
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0.2833Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2833Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2833Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2833Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4065Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.5596Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.07137Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1001Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2833Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2833Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4074Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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