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Phenotypic Abnormality (PA): Abnormality of the genital system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the genitourinary system [HP:0000119] <5>(73|72) (80|28|9)
0:   Abnormality of the genital system [HP:0000078] <3>(35|34) (37|10|3)
- 1:   Abnormal reproductive system morphology [HP:0012243] <10>(28|27) (29|4|1)
- 1:   Genital neoplasm [HP:0010787] <6>(6|5) (7|2|0)
- 1:   Abnormality of reproductive system physiology [HP:0000080] <5>(9|9) (11|3|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Restriction endonuclease-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
DNA repair protein MutS, domain III0Direct
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
ARID-like0Direct
Zn-finger domain of Sec23/240Direct
Ribonuclease H-like0.0001516Direct
SET domain0.0009089Direct
HMG-box0.01195Inherited
CalX-like0.02021Inherited
Bromodomain0.02377Inherited
HD-domain/PDEase-like0.03069Inherited
WD40 repeat-like0.03883Inherited
GAF domain-like0.04623Inherited
RuvA domain 2-like0.04623Inherited
FYVE/PHD zinc finger0.04668Inherited
Clavaminate synthase-like0.06299Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.06862Inherited
Chromo domain-like0.09916Inherited
Nuclear receptor ligand-binding domain0.102Inherited
BRCT domain0.1187Inherited
"Winged helix" DNA-binding domain0.1364Inherited
Fibrinogen C-terminal domain-like0.1491Inherited
RNA-binding domain, RBD0.157Inherited
RING/U-box0.2491Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2732Inherited
GroEL equatorial domain-like0.2982Inherited
NagB/RpiA/CoA transferase-like0.4336Inherited
Family A G protein-coupled receptor-like0.5996Inherited
Ribosomal protein S5 domain 2-like0.6301Inherited
Trypsin-like serine proteases0.6961Inherited
DEATH domain0.9034Inherited
Cytochrome P4500.9367Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
DNA repair protein MutS, domain III0Direct
Lamin A/C globular tail domain0Direct
ARID domain0Direct
Smc hinge domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
DIX domain0Direct
Dual specificity phosphatase-like0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Fibrinogen coiled-coil and central regions0Direct
DNA polymerase I0Direct
IF2B-like0Direct
Histone lysine methyltransferases0.00154Inherited
PHD domain0.006207Inherited
RING finger domain, C3HC40.007814Inherited
HMG-box0.007814Inherited
CalX-beta domain0.01442Inherited
Bromodomain0.01655Inherited
GAF domain0.03526Inherited
PDEase0.04576Inherited
RecA protein-like (ATPase-domain)0.0685Inherited
Chromo domain0.08144Inherited
Nuclear receptor ligand-binding domain0.08474Inherited
Nuclear receptor0.09748Inherited
Fibrinogen C-terminal domain-like0.1257Inherited
Canonical RBD0.1481Inherited
DNA gyrase/MutL, second domain0.1872Inherited
DNA gyrase/MutL, N-terminal domain0.1872Inherited
Extended AAA-ATPase domain0.2068Inherited
Extracellular domain of cell surface receptors0.2601Inherited
ABC transporter ATPase domain-like0.5125Inherited
Rhodopsin-like0.5128Inherited
Ngr ectodomain-like0.6847Inherited
Eukaryotic proteases0.7163Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
ARID-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Restriction endonuclease-like0Direct
DNA repair protein MutS, domain III0Direct
Lamin A/C globular tail domain0Direct
Zn-finger domain of Sec23/240Direct
Ribonuclease H-like0.00007135Direct
SET domain0.0004792Direct
DNA/RNA polymerases0.00199Inherited
HMG-box0.007789Inherited
CalX-like0.01377Inherited
Bromodomain0.01639Inherited
HD-domain/PDEase-like0.02157Inherited
WD40 repeat-like0.0279Inherited
RuvA domain 2-like0.03374Inherited
GAF domain-like0.03374Inherited
FYVE/PHD zinc finger0.03411Inherited
Clavaminate synthase-like0.04754Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.05217Inherited
Chromo domain-like0.07782Inherited
Nuclear receptor ligand-binding domain0.08025Inherited
BRCT domain0.09451Inherited
"Winged helix" DNA-binding domain0.1104Inherited
Fibrinogen C-terminal domain-like0.1217Inherited
RNA-binding domain, RBD0.1285Inherited
RING/U-box0.2124Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.235Inherited
GroEL equatorial domain-like0.2584Inherited
NagB/RpiA/CoA transferase-like0.3896Inherited
Immunoglobulin0.3937Inherited
Family A G protein-coupled receptor-like0.5567Inherited
Ribosomal protein S5 domain 2-like0.5889Inherited
Trypsin-like serine proteases0.6572Inherited
DEATH domain0.8745Inherited
Cytochrome P4500.9101Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03374Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.03374Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.1851Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03374Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0672Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1328Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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