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Phenotypic Abnormality (PA): Abnormality of the genitourinary system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the genitourinary system [HP:0000119] <5>(74|72) (79|29|9)
- 1:   Urogenital fistula [HP:0100589] <5>(1|0) (1|0|0)
- 1:   Abnormality of the urinary system [HP:0000079] <4>(38|40) (44|16|7)
- 1:   Neoplasm of the genitourinary tract [HP:0007379] <4>(6|7) (8|2|1)
- 1:   Abnormality of the genital system [HP:0000078] <3>(34|34) (36|10|3)
- 1:   Cloacal abnormality [HP:0012620] <2>(0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Smc hinge domain0Direct
Lamin A/C globular tail domain0Direct
DNA repair protein MutS, domain III0Direct
Fibrinogen coiled-coil and central regions0Direct
DNA-glycosylase0Direct
Methylglyoxal synthase-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Restriction endonuclease-like0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Putative DNA-binding domain0Direct
NAD kinase/diacylglycerol kinase-like0Direct
Tricorn protease domain 20Direct
Insulin-like0Direct
Sec63 N-terminal domain-like0Direct
Zn-finger domain of Sec23/240Direct
PRTase-like0Direct
ARID-like0Direct
SAND domain-like0Direct
Nucleoside diphosphate kinase, NDK0Direct
RING/U-box0.01045Inherited
Ribonuclease H-like0.01218Inherited
ClpP/crotonase0.01938Inherited
Alkaline phosphatase-like0.02124Inherited
NagB/RpiA/CoA transferase-like0.03862Inherited
Bromodomain0.04462Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0468Inherited
WD40 repeat-like0.04808Inherited
(Trans)glycosidases0.06035Inherited
Transcription factor STAT-4 N-domain0.06253Inherited
STAT0.06253Inherited
"Winged helix" DNA-binding domain0.06349Inherited
Actin-like ATPase domain0.06361Inherited
BRCT domain0.07117Inherited
SET domain0.07932Inherited
CalX-like0.1006Inherited
GroEL equatorial domain-like0.1006Inherited
C-type lectin-like0.1403Inherited
HMG-box0.1403Inherited
Homeodomain-like0.1569Inherited
Adenine nucleotide alpha hydrolases-like0.1573Inherited
Ypt/Rab-GAP domain of gyp1p0.1605Inherited
GAF domain-like0.1605Inherited
L-aspartase-like0.1605Inherited
4Fe-4S ferredoxins0.1605Inherited
RuvA domain 2-like0.1605Inherited
FYVE/PHD zinc finger0.1849Inherited
PreATP-grasp domain0.1975Inherited
HD-domain/PDEase-like0.1975Inherited
Glutathione synthetase ATP-binding domain-like0.2284Inherited
MHC antigen-recognition domain0.2284Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2284Inherited
Acyl-CoA dehydrogenase NM domain-like0.2284Inherited
RNA-binding domain, RBD0.3138Inherited
Acyl-CoA N-acyltransferases (Nat)0.3268Inherited
TPR-like0.3291Inherited
Clc chloride channel0.3677Inherited
Chromo domain-like0.3942Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3955Inherited
Nuclear receptor ligand-binding domain0.4012Inherited
Cysteine-rich domain0.5274Inherited
Cytochrome P4500.6037Inherited
Ribosomal protein S5 domain 2-like0.6109Inherited
Mitochondrial carrier0.6109Inherited
ARM repeat0.6295Inherited
Fibrinogen C-terminal domain-like0.7213Inherited
Complement control module/SCR domain0.7478Inherited
L domain-like0.8219Inherited
Family A G protein-coupled receptor-like0.8363Inherited
Cytokine0.8522Inherited
Trypsin-like serine proteases0.8738Inherited
DEATH domain0.9514Inherited
TNF-like0.9746Inherited
Immunoglobulin1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
beta-glycanases0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
DNA polymerase I0Direct
Lamin A/C globular tail domain0Direct
Sec63 N-terminal domain0Direct
DIX domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Smc hinge domain0Direct
IF2B-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
DNA gyrase/MutL, second domain0Direct
HCDH C-domain-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Fibrinogen coiled-coil and central regions0Direct
TBP-associated factors, TAFs0Direct
DNA gyrase/MutL, N-terminal domain0Direct
DNA repair protein MutS, domain III0Direct
Insulin-like0Direct
Phosphoribosyltransferases (PRTases)0Direct
Diacylglycerol kinase-like0Direct
ARID domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Zn-finger domain of Sec23/240Direct
Integrin alpha N-terminal domain0Direct
Cystathionine synthase-like0Direct
Cytochrome b50Direct
Dual specificity phosphatase-like0Direct
PHD domain0.001586Inherited
Bromodomain0.03509Inherited
Histone lysine methyltransferases0.03657Inherited
RecA protein-like (ATPase-domain)0.03657Inherited
Arylsulfatase0.03657Inherited
BC ATP-binding domain-like0.04961Inherited
POU-specific domain0.04961Inherited
STAT DNA-binding domain0.04961Inherited
STAT0.04961Inherited
Crotonase-like0.04961Inherited
BC N-terminal domain-like0.04961Inherited
Transcription factor STAT-4 N-domain0.04961Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.05753Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.05753Inherited
CalX-beta domain0.08271Inherited
Actin/HSP700.08808Inherited
RING finger domain, C3HC40.09031Inherited
HMG-box0.1202Inherited
GAF domain0.1363Inherited
Extended AAA-ATPase domain0.1572Inherited
Cytoplasmic domain of inward rectifier potassium channel0.172Inherited
Homeodomain0.1924Inherited
Noncollagenous (NC1) domain of collagen IV0.2Inherited
Extracellular domain of cell surface receptors0.2Inherited
MHC antigen-recognition domain0.201Inherited
PDEase0.2416Inherited
WD40-repeat0.2468Inherited
C1 set domains (antibody constant domain-like)0.3122Inherited
ABC transporter ATPase domain-like0.3204Inherited
Clc chloride channel0.3346Inherited
Chromo domain0.3614Inherited
Nuclear receptor0.3665Inherited
Nuclear receptor ligand-binding domain0.3734Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3959Inherited
Canonical RBD0.4519Inherited
Mitochondrial carrier0.585Inherited
Fibroblast growth factors (FGF)0.5902Inherited
Cytochrome P4500.6503Inherited
Fibrinogen C-terminal domain-like0.6977Inherited
Complement control module/SCR domain0.7284Inherited
Rhodopsin-like0.799Inherited
Eukaryotic proteases0.9129Inherited
TNF-like0.9672Inherited
Voltage-gated potassium channels0.9716Inherited
Ngr ectodomain-like0.9769Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nucleoside diphosphate kinase, NDK0Direct
Sec63 N-terminal domain-like0Direct
NAD kinase/diacylglycerol kinase-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
SAND domain-like0Direct
DNA repair protein MutS, domain III0Direct
Smc hinge domain0Direct
Tricorn protease domain 20Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
PRTase-like0Direct
Insulin-like0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
DNA-glycosylase0Direct
Restriction endonuclease-like0Direct
Methylglyoxal synthase-like0Direct
Fibrinogen coiled-coil and central regions0Direct
ARID-like0Direct
Zn-finger domain of Sec23/240Direct
Lamin A/C globular tail domain0Direct
Putative DNA-binding domain0Direct
RING/U-box0.006817Inherited
Ribonuclease H-like0.008076Inherited
ClpP/crotonase0.01327Inherited
Alkaline phosphatase-like0.01465Inherited
DNA/RNA polymerases0.02796Inherited
NagB/RpiA/CoA transferase-like0.02796Inherited
Bromodomain0.0328Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03456Inherited
WD40 repeat-like0.03564Inherited
(Trans)glycosidases0.04575Inherited
Transcription factor STAT-4 N-domain0.04749Inherited
STAT0.04749Inherited
"Winged helix" DNA-binding domain0.04829Inherited
Actin-like ATPase domain0.04838Inherited
BRCT domain0.05455Inherited
SET domain0.06137Inherited
GroEL equatorial domain-like0.0796Inherited
CalX-like0.0796Inherited
C-type lectin-like0.1145Inherited
HMG-box0.1145Inherited
Homeodomain-like0.1293Inherited
Adenine nucleotide alpha hydrolases-like0.1296Inherited
GAF domain-like0.1323Inherited
Ypt/Rab-GAP domain of gyp1p0.1323Inherited
RuvA domain 2-like0.1323Inherited
4Fe-4S ferredoxins0.1323Inherited
L-aspartase-like0.1323Inherited
FYVE/PHD zinc finger0.1541Inherited
HD-domain/PDEase-like0.1659Inherited
PreATP-grasp domain0.1659Inherited
lambda repressor-like DNA-binding domains0.1659Inherited
Acyl-CoA dehydrogenase NM domain-like0.194Inherited
MHC antigen-recognition domain0.194Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.194Inherited
Glutathione synthetase ATP-binding domain-like0.194Inherited
RNA-binding domain, RBD0.2747Inherited
Acyl-CoA N-acyltransferases (Nat)0.2873Inherited
TPR-like0.2895Inherited
E set domains0.2939Inherited
Clc chloride channel0.3264Inherited
Chromo domain-like0.3523Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3536Inherited
Nuclear receptor ligand-binding domain0.3591Inherited
CBS-domain pair0.3698Inherited
Cysteine-rich domain0.4841Inherited
Cytochrome P4500.5626Inherited
Ribosomal protein S5 domain 2-like0.5703Inherited
Mitochondrial carrier0.5703Inherited
ARM repeat0.5898Inherited
Fibrinogen C-terminal domain-like0.684Inherited
Complement control module/SCR domain0.7116Inherited
L domain-like0.7888Inherited
Family A G protein-coupled receptor-like0.8036Inherited
Cytokine0.8202Inherited
Trypsin-like serine proteases0.8431Inherited
DEATH domain0.9257Inherited
TNF-like0.9513Inherited
Voltage-gated potassium channels0.9637Inherited
Immunoglobulin0.9857Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.03491Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.04749Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04749Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04749Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.05455Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0786Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.1323Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1323Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.1323Inherited
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0.1323Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.1659Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.194Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.194Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1943Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.459Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.4871Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04749Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04749Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0786Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08415Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1157Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1323Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.469Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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