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Phenotypic Abnormality (PA): Microcephaly

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Abnormality of the skeletal system [HP:0000924] <7>(89|98) (94|51|33)
+ + + + + + 6:   Phenotypic abnormality [HP:0000118] <25>
+ + + + + 5:   Abnormality of head or neck [HP:0000152] <2>(87|107) (98|59|37)
+ + + + + 5:   Abnormality of skeletal morphology [HP:0011842] <18>(87|89) (90|49|32)
+ + + + + 5:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ + + + 4:   Abnormality of the head [HP:0000234] <6>(86|105) (97|58|37)
+ + + + 4:   Abnormality of brain morphology [HP:0012443] <13>(44|63) (54|31|14)
+ + + + 4:   Abnormality of nervous system morphology [HP:0012639] <5>(70|97) (81|48|16)
+ + + + 4:   Abnormal axial skeleton morphology [HP:0009121] <6>(48|61) (53|28|26)
+ + + 3:   Abnormal skull morphology [HP:0000929] <14>(27|38) (30|20|20)
+ + + 3:   Morphological abnormality of the central nervous system [HP:0002011] <17>(61|85) (71|41|16)
+ + + 3:   Abnormality of forebrain morphology [HP:0100547] <6>(26|28) (29|15|4)
+ + 2:   Abnormality of skull size [HP:0000240] <2>(15|23) (18|10|5)
+ + 2:   Aplasia/Hypoplasia involving the central nervous system [HP:0002977] <13>(18|22) (22|10|2)
+ + 2:   Abnormality of the cerebrum [HP:0002060] <16>(25|27) (28|15|4)
+ 1:   Decreased head circumference [HP:0040195] <2>(7|11) (10|3|1)
+ 1:   Aplasia/Hypoplasia of the cerebrum [HP:0007364] <5>(11|15) (12|5|1)
0:   Microcephaly [HP:0000252] <2>(7|10) (9|3|1)
- 1:   Postnatal microcephaly [HP:0005484] <2>(2|1) (2|0|0)
- 1:   Congenital microcephaly [HP:0011451](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Pseudouridine synthase0Direct
Restriction endonuclease-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
NagB/RpiA/CoA transferase-like0.03924Inherited
Ribonuclease H-like0.05452Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin domains from multidomain proteins0Direct
IF2B-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
N-acetyl transferase, NAT0Direct
Clathrin adaptor core protein0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
PHD domain0.0003366Direct
Bromodomain0.0004749Direct
ARID domain0.0007807Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Pseudouridine synthase0Direct
Restriction endonuclease-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Bromodomain0.0007071Direct
ARID-like0.000984Direct
NagB/RpiA/CoA transferase-like0.02843Inherited
Ribonuclease H-like0.04091Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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