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Phenotypic Abnormality (PA): Abnormality of the hypothalamus-pituitary axis

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the endocrine system [HP:0000818] <16>(30|34) (35|12|5)
0:   Abnormality of the hypothalamus-pituitary axis [HP:0000864] <2>(6|8) (7|2|0)
- 1:   Abnormality of the pituitary gland [HP:0012503] <5>(6|8) (7|2|0)
- 1:   Abnormal hypothalamus physiology [HP:0012285] <3>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Homeodomain-like0.005519Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.01235Inherited
p53-like transcription factors0.01553Inherited
Ribosomal protein S5 domain 2-like0.03223Inherited
Nuclear receptor ligand-binding domain0.09322Inherited
Cytochrome P4500.2808Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA gyrase/MutL, second domain0.00002784Direct
DNA gyrase/MutL, N-terminal domain0.00002784Direct
Homeodomain0.008309Inherited
HMG-box0.01139Inherited
Nuclear receptor ligand-binding domain0.07501Inherited
Nuclear receptor0.1258Inherited
Cytochrome P4500.1821Inherited
Tyrosine-dependent oxidoreductases0.1954Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Homeodomain-like0.003434Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.008189Inherited
p53-like transcription factors0.01046Inherited
HMG-box0.01113Inherited
Ribosomal protein S5 domain 2-like0.023Inherited
Nuclear receptor ligand-binding domain0.07315Inherited
Cytochrome P4500.2434Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.00002248Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.09416Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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