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Phenotypic Abnormality (PA): Abnormality of the vertebral column

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the skeletal system [HP:0000924] <7>(89|98) (94|51|33)
+ + 2:   Abnormality of skeletal morphology [HP:0011842] <18>(87|89) (90|49|32)
+ 1:   Abnormal axial skeleton morphology [HP:0009121] <6>(48|61) (53|28|26)
0:   Abnormality of the vertebral column [HP:0000925] <20>(21|27) (25|11|10)
- 1:   Abnormal vertebral morphology [HP:0003468] <16>(7|6) (8|1|2)
- 1:   Abnormality of the cervical spine [HP:0003319] <14>(3|5) (4|2|1)
- 1:   Abnormal sacrum morphology [HP:0005107] <9>(0|1) (1|0|0)
- 1:   Abnormality of the curvature of the vertebral column [HP:0010674] <6>(12|15) (13|7|4)
- 1:   Aplasia/Hypoplasia involving the vertebral column [HP:0008518] <6>(2|0) (2|0|0)
- 1:   Abnormality of the intervertebral disk [HP:0005108] <5>(1|1) (1|0|0)
- 1:   Abnormality of the coccyx [HP:0008519] <4>(0|0) (0|0|0)
- 1:   Abnormality of the odontoid process [HP:0003310] <4>(2|0) (2|0|0)
- 1:   Abnormality of the lumbar spine [HP:0100712] <3>(0|0) (0|0|0)
- 1:   Spinal canal stenosis [HP:0003416] <3>(0|0) (0|0|0)
- 1:   Abnormality of the thoracic spine [HP:0100711] <2>(2|2) (2|1|0)
- 1:   Atlantoaxial abnormality [HP:0003413] <2>(0|0) (0|0|0)
- 1:   Back pain [HP:0003418] <2>(0|0) (0|0|0)
- 1:   Spinal instability [HP:0005881] <1>(0|0) (0|0|0)
- 1:   Spondylolisthesis [HP:0003302] <1>(1|1) (1|0|0)
- 1:   Reversed usual vertebral column curves [HP:0008433](0|0) (0|0|0)
- 1:   Spinal deformities [HP:0008443](0|0) (0|0|0)
- 1:   Spinal dysplasia [HP:0008423](0|0) (0|0|0)
- 1:   Spinal rigidity [HP:0003306](0|1) (0|1|0)
- 1:   Spondylolysis [HP:0003304](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
C-terminal, gelsolin-like domain of Sec23/240Direct
Smc hinge domain0Direct
Restriction endonuclease-like0Direct
Helical domain of Sec23/240Direct
RuvA domain 2-like0Direct
Zn-finger domain of Sec23/240Direct
Alkaline phosphatase-like0.02017Inherited
HMG-box0.02226Inherited
Cystine-knot cytokines0.03948Inherited
Galactose-binding domain-like0.04329Inherited
Nucleotide-diphospho-sugar transferases0.1279Inherited
MIR domain0.2096Inherited
Notch domain0.2203Inherited
FKBP-like0.2203Inherited
WD40 repeat-like0.2267Inherited
Nicotinic receptor ligand binding domain-like0.3818Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3818Inherited
GST C-terminal domain-like0.4248Inherited
ARID-like0.4248Inherited
(Trans)glycosidases0.5715Inherited
Homeodomain-like0.896Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Myotubularin-like phosphatases0Direct
beta-sandwich domain of Sec23/240Direct
Smc hinge domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Histone deacetylase, HDAC0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Exostosin0Direct
Trunk domain of Sec23/240Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Zn-finger domain of Sec23/240Direct
Helical domain of Sec23/240Direct
Regulator of chromosome condensation RCC10.002676Inherited
Transforming growth factor (TGF)-beta0.01117Inherited
HMG-box0.01613Inherited
Arylsulfatase0.0223Inherited
beta-glycanases0.02239Inherited
T-box0.07415Inherited
Integrin A (or I) domain0.0787Inherited
MIR domain0.1746Inherited
FKBP immunophilin/proline isomerase0.1903Inherited
Notch domain0.1903Inherited
Actin/HSP700.2061Inherited
Bromodomain0.2496Inherited
Nicotinic receptor ligand binding domain-like0.3339Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3339Inherited
ARID domain0.389Inherited
Homeodomain0.8004Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
C-terminal, gelsolin-like domain of Sec23/240Direct
Smc hinge domain0Direct
Helical domain of Sec23/240Direct
RuvA domain 2-like0Direct
Restriction endonuclease-like0Direct
Zn-finger domain of Sec23/240Direct
beta-sandwich domain of Sec23/240.004155Inherited
GroEL equatorial domain-like0.008231Inherited
Alkaline phosphatase-like0.01387Inherited
HMG-box0.01542Inherited
Cystine-knot cytokines0.0286Inherited
Galactose-binding domain-like0.03172Inherited
Nucleotide-diphospho-sugar transferases0.1033Inherited
MIR domain0.1768Inherited
FKBP-like0.1864Inherited
Notch domain0.1864Inherited
WD40 repeat-like0.1924Inherited
Bromodomain0.2438Inherited
Nicotinic receptor ligand binding domain-like0.3401Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3401Inherited
GST C-terminal domain-like0.3818Inherited
ARID-like0.3818Inherited
Concanavalin A-like lectins/glucanases0.4118Inherited
(Trans)glycosidases0.5295Inherited
Homeodomain-like0.8667Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.06244Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1797Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3401Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3929Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2785Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.4854Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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