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Phenotypic Abnormality (PA): Abnormality of the skin

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the integument [HP:0001574] <4>(46|69) (58|36|15)
0:   Abnormality of the skin [HP:0000951] <4>(33|53) (45|35|12)
- 1:   Neoplasm of the skin [HP:0008069] <29>(4|5) (4|3|1)
- 1:   Abnormality of skin morphology [HP:0011121] <22>(28|47) (40|30|11)
- 1:   Abnormality of skin physiology [HP:0011122] <6>(3|7) (6|3|0)
- 1:   Abnormal perifollicular morphology [HP:0031285] <3>(1|1) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Notch domain0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
RuvA domain 2-like0Direct
Zn-finger domain of Sec23/240Direct
Integrin beta tail domain0Direct
SAND domain-like0Direct
Apolipoprotein A-I0Direct
ABC transporter transmembrane region0.004679Inherited
MHC antigen-recognition domain0.009475Inherited
DNA/RNA polymerases0.01634Inherited
Integrin domains0.03006Inherited
Globin-like0.03096Inherited
EGF/Laminin0.08047Inherited
Prefoldin0.08566Inherited
DNA repair protein MutS, domain III0.1019Inherited
ARID-like0.14Inherited
Complement control module/SCR domain0.2101Inherited
Spectrin repeat0.2373Inherited
Ribosomal protein S5 domain 2-like0.2402Inherited
Nicotinic receptor ligand binding domain-like0.2675Inherited
Bromodomain0.2675Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2675Inherited
DEATH domain0.3007Inherited
Intermediate filament protein, coiled coil region0.3251Inherited
RNI-like0.3401Inherited
alpha/beta-Hydrolases0.378Inherited
FnI-like domain0.4006Inherited
SH2 domain0.4098Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.5527Inherited
Immunoglobulin0.6021Inherited
(Trans)glycosidases0.8451Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Plakin repeat0Direct
Proteasome subunits0Direct
Caspase catalytic domain0Direct
Erythroid transcription factor GATA-10Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Integrin beta tail domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
ets domain0Direct
Apolipoprotein A-I0Direct
Histone deacetylase, HDAC0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Integrin beta EGF-like domains0Direct
Zn-finger domain of Sec23/240Direct
Notch domain0Direct
Integrin A (or I) domain0.0005499Direct
C1 set domains (antibody constant domain-like)0.001023Inherited
MHC antigen-recognition domain0.00734Inherited
GLA-domain0.01262Inherited
Integrin domains0.02434Inherited
DnaQ-like 3'-5' exonuclease0.02456Inherited
Globins0.02456Inherited
DNA gyrase/MutL, second domain0.04689Inherited
DNA gyrase/MutL, N-terminal domain0.04689Inherited
Pyrin domain, PYD0.04689Inherited
EGF-type module0.07169Inherited
beta-sandwich domain of Sec23/240.0872Inherited
C-terminal, gelsolin-like domain of Sec23/240.0872Inherited
DNA repair protein MutS, domain III0.0872Inherited
Trunk domain of Sec23/240.0872Inherited
Helical domain of Sec23/240.0872Inherited
Ras-binding domain, RBD0.1235Inherited
ARID domain0.1235Inherited
Complement control module/SCR domain0.2012Inherited
Tyrosine-dependent oxidoreductases0.2012Inherited
Spectrin repeat0.2274Inherited
Bromodomain0.2566Inherited
Nicotinic receptor ligand binding domain-like0.2566Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2566Inherited
RecA protein-like (ATPase-domain)0.3206Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.3263Inherited
DEATH domain, DD0.3282Inherited
Intermediate filament protein, coiled coil region0.3309Inherited
TNF receptor-like0.3721Inherited
Laminin-type module0.3721Inherited
SH2 domain0.416Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.4544Inherited
VWC domain0.5368Inherited
PHD domain0.6604Inherited
Histone lysine methyltransferases0.7171Inherited
G proteins0.7788Inherited
Ngr ectodomain-like0.8174Inherited
V set domains (antibody variable domain-like)0.9447Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SAND domain-like0Direct
Tricorn protease domain 20Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Plakin repeat0Direct
Apolipoprotein A-I0Direct
RuvA domain 2-like0Direct
Integrin beta tail domain0Direct
Zn-finger domain of Sec23/240Direct
Notch domain0Direct
ABC transporter transmembrane region0.002869Inherited
MHC antigen-recognition domain0.006154Inherited
vWA-like0.00697Inherited
GLA-domain0.01104Inherited
DNA/RNA polymerases0.01104Inherited
Integrin domains0.02129Inherited
Globin-like0.022Inherited
EGF/Laminin0.06238Inherited
Prefoldin0.06667Inherited
C-terminal, gelsolin-like domain of Sec23/240.08047Inherited
DNA repair protein MutS, domain III0.08047Inherited
Helical domain of Sec23/240.08047Inherited
ARID-like0.1143Inherited
P-loop containing nucleoside triphosphate hydrolases0.1516Inherited
Complement control module/SCR domain0.1772Inherited
Spectrin repeat0.2026Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2048Inherited
Ribosomal protein S5 domain 2-like0.2051Inherited
Nicotinic receptor ligand binding domain-like0.2308Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2308Inherited
Bromodomain0.2308Inherited
DEATH domain0.2623Inherited
Protein kinase-like (PK-like)0.2623Inherited
Intermediate filament protein, coiled coil region0.2856Inherited
RNI-like0.2999Inherited
alpha/beta-Hydrolases0.3364Inherited
FnI-like domain0.3585Inherited
SH2 domain0.3674Inherited
4-helical cytokines0.3918Inherited
Nucleotide-diphospho-sugar transferases0.4038Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.5103Inherited
Immunoglobulin0.5608Inherited
Adenine nucleotide alpha hydrolases-like0.5814Inherited
SET domain0.7392Inherited
(Trans)glycosidases0.8128Inherited
L domain-like0.8985Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002869Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.006154Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.01153Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.01376Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.04243Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04243Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.04243Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.06552Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.07361Inherited
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.08047Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08047Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0923Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1616Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.2308Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2856Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.2999Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.5093Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.006154Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05007Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1315Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1964Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3067Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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