SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormality of the hand

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of limbs [HP:0040064] <8>(57|64) (59|32|25)
+ 1:   Abnormality of the upper limb [HP:0002817] <20>(26|29) (30|18|16)
0:   Abnormality of the hand [HP:0001155] <26>(20|25) (24|16|14)
- 1:   Abnormality of finger [HP:0001167] <24>(11|14) (12|10|10)
- 1:   Abnormality of the carpal bones [HP:0001191] <17>(0|0) (0|0|0)
- 1:   Abnormal hand morphology [HP:0005922] <11>(2|4) (2|2|4)
- 1:   Abnormality of the metacarpal bones [HP:0001163] <11>(0|0) (1|1|1)
- 1:   Abnormal hand bone ossification [HP:0010660] <8>(0|0) (0|0|0)
- 1:   Abnormality of the musculature of the hand [HP:0001421] <6>(2|2) (2|1|0)
- 1:   Abnormality of the palm [HP:0100871] <6>(6|7) (8|2|1)
- 1:   Aplasia/hypoplasia involving bones of the hand [HP:0005927] <6>(3|6) (6|2|4)
- 1:   Abnormality of the epiphyses of the hand [HP:0005924] <4>(0|0) (0|0|0)
- 1:   Deviation of the hand or of fingers of the hand [HP:0009484] <3>(1|2) (1|0|0)
- 1:   Joint contracture of the hand [HP:0009473] <3>(0|1) (0|3|0)
- 1:   Synostosis involving bones of the hand [HP:0004278] <3>(0|0) (1|0|0)
- 1:   Abnormality of hand cortical bone [HP:0005926] <2>(0|0) (0|0|0)
- 1:   Decreased finger mobility [HP:0006135] <2>(0|0) (0|0|0)
- 1:   Duplication of hand bones [HP:0004275] <2>(2|1) (2|1|0)
- 1:   Osteolytic defects of the hand bones [HP:0009699] <2>(0|0) (0|0|0)
- 1:   Abnormalities of the metaphyses of the hand [HP:0005923] <1>(0|0) (0|0|0)
- 1:   Abnormality of hand joint mobility [HP:0006256] <1>(1|1) (1|1|0)
- 1:   Autoamputation of digits [HP:0007460] <1>(0|0) (0|0|0)
- 1:   Abnormalities of the diaphyses of the hand [HP:0005925](0|0) (0|0|0)
- 1:   Abnormality of dorsoventral patterning of the limbs [HP:0100270](0|0) (0|0|0)
- 1:   Exostoses of hand bones [HP:0004276](0|0) (0|0|0)
- 1:   Fractured hand bones [HP:0004277](0|0) (0|0|0)
- 1:   Short tubular bones of the hand [HP:0001248](0|0) (0|0|0)
- 1:   Split hand [HP:0001171](0|0) (0|0|0)
- 1:   Ulnar claw [HP:0001178](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Plakin repeat0Direct
RuvA domain 2-like0Direct
WD40 repeat-like0.002144Inherited
EGF/Laminin0.00911Inherited
GroEL equatorial domain-like0.01265Inherited
BRK domain-like0.03256Inherited
Arginase/deacetylase0.03256Inherited
Restriction endonuclease-like0.03256Inherited
Insulin-like0.03256Inherited
ARID-like0.0377Inherited
Prefoldin0.07407Inherited
Multidrug efflux transporter AcrB transmembrane domain0.08158Inherited
vWA-like0.2324Inherited
Nicotinic receptor ligand binding domain-like0.2411Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2411Inherited
p53-like transcription factors0.266Inherited
HLH, helix-loop-helix DNA-binding domain0.4973Inherited
Intermediate filament protein, coiled coil region0.5227Inherited
Cystine-knot cytokines0.5495Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.9752Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Plakin repeat0Direct
Proteasome subunits0Direct
XPF/Rad1/Mus81 nuclease0Direct
Histone deacetylase, HDAC0Direct
Exostosin0Direct
Erythroid transcription factor GATA-10.0008827Direct
TB module/8-cys domain0.008023Inherited
Classic zinc finger, C2H20.01529Inherited
Insulin-like0.02246Inherited
Notch domain0.02246Inherited
BRK domain-like0.02246Inherited
ARID domain0.02628Inherited
Laminin-type module0.03257Inherited
Integrin A (or I) domain0.03287Inherited
Bromodomain0.04071Inherited
VWC domain0.05523Inherited
Nicotinic receptor ligand binding domain-like0.1979Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1979Inherited
Homeodomain0.3185Inherited
Tyrosine-dependent oxidoreductases0.335Inherited
I set domains0.4173Inherited
HLH, helix-loop-helix DNA-binding domain0.4851Inherited
Intermediate filament protein, coiled coil region0.5104Inherited
Transforming growth factor (TGF)-beta0.5966Inherited
RecA protein-like (ATPase-domain)0.7772Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Plakin repeat0Direct
RuvA domain 2-like0Direct
WD40 repeat-like0.001229Inherited
SET domain0.001713Inherited
EGF/Laminin0.005905Inherited
GroEL equatorial domain-like0.008408Inherited
TB module/8-cys domain0.008408Inherited
BRK domain-like0.02324Inherited
Insulin-like0.02324Inherited
Arginase/deacetylase0.02324Inherited
Restriction endonuclease-like0.02324Inherited
Notch domain0.02324Inherited
ARID-like0.02729Inherited
Bromodomain0.04299Inherited
Prefoldin0.05706Inherited
Multidrug efflux transporter AcrB transmembrane domain0.06334Inherited
vWA-like0.1977Inherited
Nicotinic receptor ligand binding domain-like0.206Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.206Inherited
p53-like transcription factors0.2294Inherited
HLH, helix-loop-helix DNA-binding domain0.4538Inherited
Intermediate filament protein, coiled coil region0.4794Inherited
Cystine-knot cytokines0.5068Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.952Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.001858Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.004374Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.005581Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.008408Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.008408Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.02324Inherited
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.02324Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.02729Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.06334Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1171Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1339Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1791Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.206Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001858Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.008408Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.008408Inherited
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.02324Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02633Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.02729Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2881Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)