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Phenotypic Abnormality (PA): Intellectual disability

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ + 2:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
+ 1:   Neurodevelopmental abnormality [HP:0012759] <5>(34|50) (39|26|11)
+ 1:   Abnormality of higher mental function [HP:0011446] <9>(38|46) (42|25|8)
0:   Intellectual disability [HP:0001249] <6>(10|11) (10|5|2)
- 1:   Intellectual disability, borderline [HP:0006889](0|0) (0|0|0)
- 1:   Intellectual disability, mild [HP:0001256](0|0) (1|0|0)
- 1:   Intellectual disability, moderate [HP:0002342](1|0) (1|0|0)
- 1:   Intellectual disability, profound [HP:0002187](1|0) (1|0|0)
- 1:   Intellectual disability, progressive [HP:0006887](0|0) (0|0|0)
- 1:   Intellectual disability, severe [HP:0010864](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
BRK domain-like0Direct
Arginase/deacetylase0Direct
ADC-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
PP2C-like0Direct
Bromodomain0.000852Direct
S-adenosyl-L-methionine-dependent methyltransferases0.1442Inherited
GST C-terminal domain-like0.4575Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin domains from multidomain proteins0Direct
Lamin A/C globular tail domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
PP2C-like0Direct
Histone deacetylase, HDAC0Direct
L-aspartase/fumarase0Direct
Exostosin0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
CUT domain0Direct
BRK domain-like0Direct
Bromodomain0.0004106Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PP2C-like0Direct
BRK domain-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
ADC-like0Direct
Arginase/deacetylase0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Lamin A/C globular tail domain0Direct
Bromodomain0.0004578Direct
S-adenosyl-L-methionine-dependent methyltransferases0.1179Inherited
GST C-terminal domain-like0.4146Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)