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Phenotypic Abnormality (PA): Abnormality of the cardiovascular system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the cardiovascular system [HP:0001626] <5>(59|81) (72|39|29)
- 1:   Abnormal cardiovascular system physiology [HP:0011025] <16>(21|32) (30|17|14)
- 1:   Abnormality of the vasculature [HP:0002597] <13>(33|53) (44|26|18)
- 1:   Abnormal cardiac test [HP:0500015] <7>(1|3) (1|1|0)
- 1:   Abnormality of the fetal cardiovascular system [HP:0010948] <7>(0|0) (0|0|0)
- 1:   Abnormality of cardiovascular system morphology [HP:0030680] <3>(29|40) (32|17|20)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Smc hinge domain0Direct
GLA-domain0Direct
Notch domain0Direct
GAF domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
DPP6 N-terminal domain-like0Direct
TB module/8-cys domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Saposin0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
RmlC-like cupins0Direct
Zn-finger domain of Sec23/240Direct
Creatinase/prolidase N-terminal domain0Direct
SAND domain-like0Direct
Apolipoprotein A-I0Direct
Nucleoside diphosphate kinase, NDK0Direct
Creatinase/aminopeptidase0Direct
TNF receptor-like0.01547Inherited
Glycosyl hydrolase domain0.01692Inherited
Actin-like ATPase domain0.02699Inherited
Growth factor receptor domain0.03177Inherited
(Trans)glycosidases0.03462Inherited
cAMP-binding domain-like0.0394Inherited
DEATH domain0.04114Inherited
Spectrin repeat0.05497Inherited
Globin-like0.07048Inherited
SMAD MH1 domain0.1108Inherited
p53-like transcription factors0.1113Inherited
Tropomyosin0.1205Inherited
Protein kinase-like (PK-like)0.128Inherited
Caspase-like0.1738Inherited
MIR domain0.1743Inherited
DNA/RNA polymerases0.1743Inherited
Immunoglobulin0.1887Inherited
4-helical cytokines0.1923Inherited
Snake toxin-like0.1923Inherited
Integrin domains0.2196Inherited
Trypsin-like serine proteases0.2371Inherited
ARID-like0.2478Inherited
MHC antigen-recognition domain0.2539Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2885Inherited
TNF-like0.3049Inherited
FnI-like domain0.3049Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.33Inherited
Myosin rod fragments0.33Inherited
SMAD/FHA domain0.3564Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3943Inherited
RNI-like0.3966Inherited
Fibrinogen C-terminal domain-like0.5448Inherited
Voltage-gated potassium channels0.57Inherited
Cadherin-like0.5777Inherited
L domain-like0.7036Inherited
Ribosomal protein S5 domain 2-like0.7993Inherited
(Phosphotyrosine protein) phosphatases II0.848Inherited
FAD/NAD(P)-binding domain0.8919Inherited
Nicotinic receptor ligand binding domain-like0.9684Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9684Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
beta-glycanases0Direct
Plakin repeat0Direct
GAF domain0Direct
Proteasome subunits0Direct
Erythroid transcription factor GATA-10Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Smc hinge domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
ets domain0Direct
Apolipoprotein A-I0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
GLA-domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Creatinase/aminopeptidase0Direct
Zn-finger domain of Sec23/240Direct
Notch domain0Direct
TB module/8-cys domain0Direct
Putative glucosidase YicI, domain 30Direct
ZZ domain0Direct
EGF-type module0.004966Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.01235Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.01235Inherited
Actin/HSP700.02087Inherited
Growth factor receptor domain0.02753Inherited
TNF receptor-like0.0285Inherited
Spectrin repeat0.04493Inherited
Globins0.05715Inherited
Amylase, catalytic domain0.09234Inherited
SMAD domain0.09234Inherited
DNA gyrase/MutL, second domain0.09234Inherited
DNA gyrase/MutL, N-terminal domain0.09234Inherited
SMAD MH1 domain0.09234Inherited
Pyrin domain, PYD0.09234Inherited
ABC transporter ATPase domain-like0.0967Inherited
Tropomyosin0.1013Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1013Inherited
Calponin-homology domain, CH-domain0.113Inherited
Protein kinases, catalytic subunit0.1187Inherited
PHD domain0.1276Inherited
Histone lysine methyltransferases0.1384Inherited
RecA protein-like (ATPase-domain)0.1384Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.1488Inherited
NADPH-cytochrome p450 reductase-like0.1488Inherited
Double-stranded RNA-binding domain (dsRBD)0.1488Inherited
MIR domain0.1504Inherited
Tetratricopeptide repeat (TPR)0.178Inherited
Integrin domains0.1943Inherited
Cytoplasmic domain of inward rectifier potassium channel0.1943Inherited
DEATH domain, DD0.196Inherited
T-box0.196Inherited
C1 set domains (antibody constant domain-like)0.196Inherited
Ras-binding domain, RBD0.2195Inherited
STAT DNA-binding domain0.2195Inherited
STAT0.2195Inherited
ARID domain0.2195Inherited
Extracellular domain of cell surface receptors0.2195Inherited
Transcription factor STAT-4 N-domain0.2195Inherited
MHC antigen-recognition domain0.2279Inherited
Transforming growth factor (TGF)-beta0.2384Inherited
TNF-like0.2787Inherited
Myosin rod fragments0.3014Inherited
28-residue LRR0.3014Inherited
Caspase recruitment domain, CARD0.3169Inherited
LIM domain0.3291Inherited
Eukaryotic proteases0.3408Inherited
VWC domain0.363Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.363Inherited
Voltage-gated potassium channels0.4095Inherited
DnaQ-like 3'-5' exonuclease0.4817Inherited
Fibrinogen C-terminal domain-like0.516Inherited
Calmodulin-like0.6305Inherited
Cadherin0.6314Inherited
V set domains (antibody variable domain-like)0.7179Inherited
Second domain of FERM0.8535Inherited
Ngr ectodomain-like0.9474Inherited
Intermediate filament protein, coiled coil region0.9608Inherited
Nicotinic receptor ligand binding domain-like0.9616Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9616Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nucleoside diphosphate kinase, NDK0Direct
SAND domain-like0Direct
GAF domain-like0Direct
Smc hinge domain0Direct
Tricorn protease domain 20Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
RmlC-like cupins0Direct
Creatinase/aminopeptidase0Direct
DPP6 N-terminal domain-like0Direct
GLA-domain0Direct
Creatinase/prolidase N-terminal domain0Direct
Plakin repeat0Direct
Apolipoprotein A-I0Direct
TB module/8-cys domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Fibrinogen coiled-coil and central regions0Direct
Zn-finger domain of Sec23/240Direct
Notch domain0Direct
Saposin0Direct
TNF receptor-like0.0104Inherited
Glycosyl hydrolase domain0.01146Inherited
Actin-like ATPase domain0.01895Inherited
Growth factor receptor domain0.02264Inherited
(Trans)glycosidases0.02488Inherited
cAMP-binding domain-like0.02857Inherited
DEATH domain0.02993Inherited
Spectrin repeat0.0413Inherited
Globin-like0.05397Inherited
SMAD MH1 domain0.08815Inherited
Acyl-CoA N-acyltransferases (Nat)0.08815Inherited
p53-like transcription factors0.08853Inherited
Acyl-CoA dehydrogenase NM domain-like0.09177Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.09177Inherited
Tropomyosin0.09655Inherited
Protein kinase-like (PK-like)0.1034Inherited
Calponin-homology domain, CH-domain0.1053Inherited
Caspase-like0.1439Inherited
Restriction endonuclease-like0.1439Inherited
MIR domain0.1443Inherited
DNA/RNA polymerases0.1443Inherited
Immunoglobulin0.1577Inherited
4-helical cytokines0.1611Inherited
Snake toxin-like0.1611Inherited
Integrin domains0.1858Inherited
Complement control module/SCR domain0.1936Inherited
Trypsin-like serine proteases0.2024Inherited
Transcription factor STAT-4 N-domain0.2119Inherited
STAT0.2119Inherited
ARID-like0.2119Inherited
MHC antigen-recognition domain0.2178Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2506Inherited
FnI-like domain0.2664Inherited
TNF-like0.2664Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2904Inherited
Myosin rod fragments0.2904Inherited
SMAD/FHA domain0.3154Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3524Inherited
RNI-like0.3547Inherited
Fibrinogen C-terminal domain-like0.5021Inherited
Voltage-gated potassium channels0.5279Inherited
Cadherin-like0.5356Inherited
Cystine-knot cytokines0.5487Inherited
SH3-domain0.5681Inherited
L domain-like0.6656Inherited
EF-hand0.7426Inherited
Ribosomal protein S5 domain 2-like0.7652Inherited
(Phosphotyrosine protein) phosphatases II0.8158Inherited
Second domain of FERM0.8246Inherited
FAD/NAD(P)-binding domain0.8623Inherited
Intermediate filament protein, coiled coil region0.9419Inherited
Nicotinic receptor ligand binding domain-like0.9445Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9445Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.006684Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.01146Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.02648Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02857Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.04273Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0541Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.06325Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.08339Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08815Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.08815Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.08815Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.09177Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1523Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.1858Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2119Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2119Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2119Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2119Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2178Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.4043Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.9445Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003779Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.006684Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01953Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.03254Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03254Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.09655Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1176Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1439Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2119Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2119Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2578Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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