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Phenotypic Abnormality (PA): Splenomegaly

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
+ + + + 4:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
+ + + + 4:   Abnormality of the vasculature [HP:0002597] <13>(35|56) (45|27|18)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the digestive system [HP:0025031] <6>(67|77) (77|46|25)
+ + + 3:   Abnormality of the lymphatic system [HP:0100763] <7>(9|19) (15|8|5)
+ + + 3:   Abnormality of the abdominal organs [HP:0002012] <6>(27|27) (30|13|4)
+ + 2:   Abnormality of abdomen morphology [HP:0001438] <7>(6|10) (8|5|2)
+ + 2:   Abnormality of the spleen [HP:0001743] <2>(7|14) (9|4|3)
+ 1:   Abnormal spleen morphology [HP:0025408] <11>(7|13) (9|4|3)
+ 1:   Visceromegaly [HP:0003271] <3>(6|10) (8|5|2)
0:   Splenomegaly [HP:0001744] <1>(4|10) (6|4|2)
- 1:   Fluctuating splenomegaly [HP:0006268](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DEATH domain0.00000004945Direct
TNF receptor-like0.00000316Direct
Globin-like0.00001027Direct
Notch domain0.0009026Direct


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Globins0.000006408Direct
Pyrin domain, PYD0.00006518Direct
TNF receptor-like0.0001098Direct
Notch domain0.0005891Direct
beta-glycanases0.0005891Direct
28-residue LRR0.0006554Direct
DEATH domain, DD0.0007083Direct
PX domain0.0008527Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DEATH domain0.00000001914Direct
TNF receptor-like0.000001296Direct
Globin-like0.000004341Direct
Notch domain0.0004762Direct
PX domain0.0006764Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0006764Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000001166Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00004759Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0004762Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0004762Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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