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Phenotypic Abnormality (PA): Weight loss

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Growth abnormality [HP:0001507] <6>(29|48) (34|24|15)
+ + 2:   Abnormality of body weight [HP:0004323] <4>(9|23) (13|12|3)
+ 1:   Decreased body weight [HP:0004325] <6>(8|15) (9|8|2)
0:   Weight loss [HP:0001824] <1>(4|8) (5|6|2)
- 1:   Cachexia [HP:0004326](1|1) (2|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
MHC antigen-recognition domain0.00002924Direct
Transcription factor STAT-4 N-domain0.0001398Direct
STAT0.0001398Direct
vWA-like0.1363Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA gyrase/MutL, second domain0.00001863Direct
DNA gyrase/MutL, N-terminal domain0.00001863Direct
MHC antigen-recognition domain0.00002068Direct
STAT DNA-binding domain0.00009388Direct
STAT0.00009388Direct
Transcription factor STAT-4 N-domain0.00009388Direct
C1 set domains (antibody constant domain-like)0.0002086Direct
Integrin A (or I) domain0.04871Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MHC antigen-recognition domain0.00001341Direct
Transcription factor STAT-4 N-domain0.0000679Direct
STAT0.0000679Direct
Concanavalin A-like lectins/glucanases0.06957Inherited
vWA-like0.111Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.00001315Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00001341Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0000679Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000679Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000679Direct
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.0007201Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000679Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000679Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)