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Phenotypic Abnormality (PA): Abnormality of blood and blood-forming tissues
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this HP term (SDHP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Proteasome subunits | 0 | DIRECT |
Globins | 0 | DIRECT |
Fibrinogen coiled-coil and central regions | 0 | DIRECT |
Eukaryotic proteases | 0.000001139 | DIRECT |
SH2 domain | 0.00003831 | DIRECT |
GLA-domain | 0.001407 | INHERITED FROM: Post-partum hemorrhage || Abnormal prothrombin time || Deep venous thrombosis || Internal hemorrhage || Prolonged prothrombin time || Abnormality of the coagulation cascade || Abnormal bleeding || Venous thrombosis || Prolonged bleeding following procedure || Abnormality of coagulation || Joint hemorrhage |
DEATH domain, DD | 0.006967 | INHERITED FROM: Subcutaneous hemorrhage || Lymphoma |
Complement control module/SCR domain | 0.008797 | INHERITED FROM: Anemia due to reduced life span of red cells || Microangiopathic hemolytic anemia || Schistocytosis || Reticulocytosis || Abnormal platelet count |
Ras GEF | 0.01096 | INHERITED FROM: Abnormal thrombocyte morphology || Abnormal bleeding |
DNA gyrase/MutL, second domain | 0.01096 | INHERITED FROM: Internal hemorrhage || Abnormal bleeding || Gastrointestinal hemorrhage |
DNA gyrase/MutL, N-terminal domain | 0.01096 | INHERITED FROM: Internal hemorrhage || Abnormal bleeding || Gastrointestinal hemorrhage |
Pyrin domain, PYD | 0.01096 | INHERITED FROM: Abnormal leukocyte count || Abnormal leukocyte morphology || Leukocytosis |
Kringle modules | 0.02868 | INHERITED FROM: Deep venous thrombosis || Abnormality of coagulation |
ABC transporter ATPase domain-like | 0.02924 | INHERITED FROM: Stomatocytosis || Episodic hemolytic anemia |
Nitrogenase iron protein-like | 0.03468 | INHERITED FROM: Abnormality of multiple cell lineages in the bone marrow || Abnormal leukocyte count || Lymphopenia || Pancytopenia |
Transcription factor STAT-4 N-domain | 0.03468 | INHERITED FROM: Leukopenia || Thrombocytopenia || Neutropenia || Abnormal neutrophil count || Abnormal leukocyte count || Abnormal platelet count || Abnormal thrombocyte morphology |
STAT DNA-binding domain | 0.03468 | INHERITED FROM: Leukopenia || Thrombocytopenia || Neutropenia || Abnormal neutrophil count || Abnormal leukocyte count || Abnormal platelet count || Abnormal thrombocyte morphology |
STAT | 0.03468 | INHERITED FROM: Leukopenia || Thrombocytopenia || Neutropenia || Abnormal neutrophil count || Abnormal leukocyte count || Abnormal platelet count || Abnormal thrombocyte morphology |
MHC antigen-recognition domain | 0.05472 | INHERITED FROM: Venous thrombosis |
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0.07114 | INHERITED FROM: Bruising susceptibility |
BEACH domain | 0.07646 | INHERITED FROM: Abnormality of bone marrow cell morphology || Abnormality of multiple cell lineages in the bone marrow |
Fibrinogen C-terminal domain-like | 0.09926 | INHERITED FROM: Abnormality of the common coagulation pathway || Abnormality of circulating fibrinogen || Internal hemorrhage || Venous thrombosis |
28-residue LRR | 0.09926 | INHERITED FROM: Leukocytosis |
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.1191 | INHERITED FROM: Abnormal thrombocyte morphology |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.1379 | INHERITED FROM: Leukopenia |
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0.1718 | INHERITED FROM: Intracranial hemorrhage |
Integrin domains | 0.1718 | INHERITED FROM: Subarachnoid hemorrhage || Spontaneous hematomas || Intracranial hemorrhage || Cephalohematoma || Petechiae || Ecchymosis || Purpura || Neonatal alloimmune thrombocytopenia || Macular purpura || Melena |
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0.1718 | INHERITED FROM: Intracranial hemorrhage |
VWC domain | 0.2081 | INHERITED FROM: Bruising susceptibility |
RecA protein-like (ATPase-domain) | 0.2319 | INHERITED FROM: Sideroblastic anemia || Pyridoxine-responsive sideroblastic anemia || Myelodysplasia |
Second domain of FERM | 0.2521 | INHERITED FROM: Cerebral hemorrhage |
G proteins | 0.2826 | INHERITED FROM: Abnormal platelet function |
Transglutaminase core | 0.2843 | INHERITED FROM: Abnormality of the common coagulation pathway || Abnormality of the coagulation cascade |
V set domains (antibody variable domain-like) | 0.3015 | INHERITED FROM: Abnormal lymphocyte morphology |
Ngr ectodomain-like | 0.964 | INHERITED FROM: Abnormal platelet aggregation || Abnormal megakaryocyte morphology || Macrothrombocytopenia || Spontaneous, recurrent epistaxis || Spontaneous hematomas || Impaired platelet aggregation || Prolonged bleeding after surgery || Prolonged bleeding time || Giant platelets || Prolonged bleeding after dental extraction || Hematemesis || Menorrhagia || Decreased platelet glycoprotein Ib-IX-V || Impaired ristocetin-induced platelet aggregation || Abnormal platelet membrane protein expression || Abnormality of von Willebrand factor || Abnormal platelet volume || Prolonged bleeding following procedure || Increased mean platelet volume |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Download Newick format tree:
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this HP term (SPHO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP | 0 | DIRECT |
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin | 0 | DIRECT |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.0001093 | DIRECT |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0.0003562 | DIRECT |
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like | 0.0006806 | DIRECT |
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.0009696 | DIRECT |
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases | 0.001114 | INHERITED FROM: Deep venous thrombosis || Venous thrombosis |
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like | 0.009418 | INHERITED FROM: Internal hemorrhage || Abnormal bleeding || Gastrointestinal hemorrhage |
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009418 | INHERITED FROM: Leukocytosis |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.02079 | INHERITED FROM: Anemia of inadequate production |
50729,81837 50729 - PH domain-like 81837 - BEACH domain | 0.02533 | INHERITED FROM: Abnormal thrombocyte morphology || Abnormal platelet count || Abnormality of bone marrow cell morphology || Thrombocytopenia || Abnormality of multiple cell lineages in the bone marrow |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.0296 | INHERITED FROM: Abnormality of coagulation |
47655,49417 47655 - STAT 49417 - p53-like transcription factors | 0.03018 | INHERITED FROM: Abnormal leukocyte count || Abnormal thrombocyte morphology || Abnormal platelet count || Neutropenia || Leukopenia || Abnormal neutrophil count || Thrombocytopenia |
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain | 0.03018 | INHERITED FROM: Abnormal leukocyte count || Abnormal thrombocyte morphology || Abnormal platelet count || Neutropenia || Leukopenia || Abnormal neutrophil count || Thrombocytopenia |
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT | 0.03018 | INHERITED FROM: Abnormal leukocyte count || Abnormal thrombocyte morphology || Abnormal platelet count || Neutropenia || Leukopenia || Abnormal neutrophil count || Thrombocytopenia |
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin | 0.04675 | INHERITED FROM: Venous thrombosis |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP | 0 | Direct |
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin | 0 | Direct |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.0001093 | Direct |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0.0003562 | Direct |
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like | 0.0006806 | Direct |
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.0009696 | Direct |
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases | 0.001114 | Inherited |
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like | 0.009418 | Inherited |
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009418 | Inherited |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.02079 | Inherited |
50729,81837 50729 - PH domain-like 81837 - BEACH domain | 0.02533 | Inherited |
57440,57440 57440 - Kringle-like 57440 - Kringle-like | 0.0296 | Inherited |
47655,49417 47655 - STAT 49417 - p53-like transcription factors | 0.03018 | Inherited |
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain | 0.03018 | Inherited |
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT | 0.03018 | Inherited |
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin | 0.04675 | Inherited |
(show details)
Supra-domains annotated to this HP term (SPHO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.00003269 | DIRECT |
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases | 0.009418 | INHERITED FROM: Abnormality of coagulation |
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors | 0.03018 | INHERITED FROM: Abnormal leukocyte count || Abnormal thrombocyte morphology || Abnormal platelet count || Neutropenia || Leukopenia || Abnormal neutrophil count || Thrombocytopenia |
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain | 0.03018 | INHERITED FROM: Abnormal leukocyte count || Abnormal thrombocyte morphology || Abnormal platelet count || Neutropenia || Leukopenia || Abnormal neutrophil count || Thrombocytopenia |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.00003269 | Direct |
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases | 0.009418 | Inherited |
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors | 0.03018 | Inherited |
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain | 0.03018 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|