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Phenotypic Abnormality (PA): Abnormality of blood and blood-forming tissues

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of blood and blood-forming tissues [HP:0001871] <11>(24|35) (31|16|5)
- 1:   Abnormal erythrocyte morphology [HP:0001877] <20>(3|6) (4|2|1)
- 1:   Abnormal bleeding [HP:0001892] <16>(8|15) (14|3|1)
- 1:   Hematological neoplasm [HP:0004377] <7>(2|2) (2|1|0)
- 1:   Abnormality of coagulation [HP:0001928] <6>(6|7) (6|3|2)
- 1:   Abnormal thrombosis [HP:0001977] <5>(5|5) (6|2|0)
- 1:   Abnormality of bone marrow cell morphology [HP:0005561] <5>(3|4) (3|1|0)
- 1:   Abnormal leukocyte morphology [HP:0001881] <4>(8|9) (9|5|2)
- 1:   Abnormal thrombocyte morphology [HP:0001872] <4>(7|11) (7|7|4)
- 1:   Abnormal erythrocyte physiology [HP:0020054] <3>(0|0) (0|0|0)
- 1:   Abnormal myeloid cell morphology [HP:0020047] <1>(0|0) (0|0|0)
- 1:   Extramedullary hematopoiesis [HP:0001978](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Globin-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Trypsin-like serine proteases0.0000004419Direct
SH2 domain0.00004311Direct
DEATH domain0.00008938Direct
GLA-domain0.001986Inherited
TNF receptor-like0.00406Inherited
Complement control module/SCR domain0.0103Inherited
Ras GEF0.01424Inherited
Snake toxin-like0.03382Inherited
Hairpin loop containing domain-like0.03549Inherited
RNI-like0.03883Inherited
Transcription factor STAT-4 N-domain0.04186Inherited
STAT0.04186Inherited
Kringle-like0.06582Inherited
Immunoglobulin0.07647Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.08095Inherited
BEACH domain0.08836Inherited
4-helical cytokines0.0928Inherited
Fibrinogen C-terminal domain-like0.1103Inherited
Integrin domains0.1869Inherited
p53-like transcription factors0.2245Inherited
FYVE/PHD zinc finger0.6326Inherited
L domain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Globins0Direct
Fibrinogen coiled-coil and central regions0Direct
Eukaryotic proteases0.000001139Direct
SH2 domain0.00003831Direct
GLA-domain0.001407Inherited
DEATH domain, DD0.006967Inherited
Complement control module/SCR domain0.008797Inherited
Ras GEF0.01096Inherited
DNA gyrase/MutL, second domain0.01096Inherited
DNA gyrase/MutL, N-terminal domain0.01096Inherited
Pyrin domain, PYD0.01096Inherited
Kringle modules0.02868Inherited
ABC transporter ATPase domain-like0.02924Inherited
Nitrogenase iron protein-like0.03468Inherited
Transcription factor STAT-4 N-domain0.03468Inherited
STAT DNA-binding domain0.03468Inherited
STAT0.03468Inherited
MHC antigen-recognition domain0.05472Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.07114Inherited
BEACH domain0.07646Inherited
Fibrinogen C-terminal domain-like0.09926Inherited
28-residue LRR0.09926Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1191Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.1379Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.1718Inherited
Integrin domains0.1718Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.1718Inherited
VWC domain0.2081Inherited
RecA protein-like (ATPase-domain)0.2319Inherited
Second domain of FERM0.2521Inherited
G proteins0.2826Inherited
Transglutaminase core0.2843Inherited
V set domains (antibody variable domain-like)0.3015Inherited
Ngr ectodomain-like0.964Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Globin-like0Direct
Trypsin-like serine proteases0.0000001737Direct
SH2 domain0.00001918Direct
DEATH domain0.00004095Direct
GLA-domain0.001114Inherited
TNF receptor-like0.002416Inherited
Complement control module/SCR domain0.006648Inherited
Ras GEF0.009418Inherited
P-loop containing nucleoside triphosphate hydrolases0.02018Inherited
Snake toxin-like0.02401Inherited
Hairpin loop containing domain-like0.02533Inherited
RNI-like0.0279Inherited
Transcription factor STAT-4 N-domain0.03018Inherited
STAT0.03018Inherited
MHC antigen-recognition domain0.04675Inherited
Kringle-like0.04982Inherited
Immunoglobulin0.0587Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.06243Inherited
BEACH domain0.06857Inherited
4-helical cytokines0.07235Inherited
Fibrinogen C-terminal domain-like0.08699Inherited
EGF/Laminin0.1509Inherited
Integrin domains0.1551Inherited
FnI-like domain0.1811Inherited
Second domain of FERM0.1868Inherited
p53-like transcription factors0.1897Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2117Inherited
FYVE/PHD zinc finger0.5915Inherited
Cystine-knot cytokines0.6256Inherited
L domain-like0.9961Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0001093Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0003562Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0006806Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0009696Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.001114Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.009418Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.009418Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.02079Inherited
    50729,81837
  • 50729 - PH domain-like
  • 81837 - BEACH domain
  • 0.02533Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0296Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03018Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03018Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.03018Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.04675Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.00003269Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.009418Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03018Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03018Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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