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Phenotypic Abnormality (PA): Acidosis

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(75|82) (79|40|16)
+ + 2:   Abnormal homeostasis [HP:0012337] <8>(44|47) (44|22|8)
+ 1:   Abnormality of acid-base homeostasis [HP:0004360] <7>(19|16) (19|7|2)
0:   Acidosis [HP:0001941] <8>(13|12) (13|5|2)
- 1:   Lactic acidosis [HP:0003128] <7>(3|3) (3|2|1)
- 1:   Metabolic acidosis [HP:0001942] <5>(0|0) (0|0|0)
- 1:   Chronic acidosis [HP:0012468] <3>(0|0) (0|0|0)
- 1:   Ketoacidosis [HP:0001993] <3>(0|0) (0|0|0)
- 1:   Renal tubular acidosis [HP:0001947] <3>(0|0) (0|0|0)
- 1:   Respiratory acidosis [HP:0005972] <2>(0|0) (0|0|0)
- 1:   Hyperchloremic acidosis [HP:0001995] <1>(0|0) (0|0|0)
- 1:   Increased serum lactate [HP:0002151] <1>(2|1) (2|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
ClpP/crotonase0.000007794Direct
Single hybrid motif0.000009128Direct
Thiamin diphosphate-binding fold (THDP-binding)0.00002502Direct
Nucleotidylyl transferase0.00002671Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.00006272Direct
Acyl-CoA dehydrogenase NM domain-like0.00006272Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00006272Direct
Terpenoid synthases0.0005333Direct
Rudiment single hybrid motif0.0005333Direct
4Fe-4S ferredoxins0.0005333Direct
Translation proteins0.003187Inherited
Mitochondrial carrier0.6706Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
HCDH C-domain-like0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.000001481Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.000004855Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.000004855Direct
Biotinyl/lipoyl-carrier proteins and domains0.000004855Direct
Crotonase-like0.0001369Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0002599Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0.0003082Direct
Branched-chain alpha-keto acid dehydrogenase PP module0.0003082Direct
BC C-terminal domain-like0.0003082Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.6255Inherited
Mitochondrial carrier0.6255Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
ClpP/crotonase0.00000324Direct
Single hybrid motif0.000003815Direct
Thiamin diphosphate-binding fold (THDP-binding)0.00001089Direct
Nucleotidylyl transferase0.00001167Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00002839Direct
Acyl-CoA dehydrogenase NM domain-like0.00002839Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.00002839Direct
Terpenoid synthases0.0002704Direct
Rudiment single hybrid motif0.0002704Direct
4Fe-4S ferredoxins0.0002704Direct
Translation proteins0.001855Inherited
Mitochondrial carrier0.6304Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.0000001295Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.00002839Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.0002704Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.0002704Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)