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Phenotypic Abnormality (PA): Acidosis

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(76|83) (79|38|16)
+ + 2:   Abnormal homeostasis [HP:0012337] <8>(42|43) (42|21|8)
+ 1:   Abnormality of acid-base homeostasis [HP:0004360] <7>(19|15) (19|7|2)
0:   Acidosis [HP:0001941] <8>(12|11) (12|5|2)
- 1:   Lactic acidosis [HP:0003128] <7>(2|2) (2|2|1)
- 1:   Metabolic acidosis [HP:0001942] <5>(0|0) (0|0|0)
- 1:   Chronic acidosis [HP:0012468] <3>(0|0) (0|0|0)
- 1:   Ketoacidosis [HP:0001993] <3>(0|0) (0|0|0)
- 1:   Renal tubular acidosis [HP:0001947] <3>(0|0) (0|0|0)
- 1:   Respiratory acidosis [HP:0005972] <2>(0|0) (0|0|0)
- 1:   Hyperchloremic acidosis [HP:0001995] <1>(0|0) (0|0|0)
- 1:   Increased serum lactate [HP:0002151] <1>(3|1) (3|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
ClpP/crotonase0.00000635Direct
Single hybrid motif0.00000759Direct
Nucleotidylyl transferase0.00001291Direct
Thiamin diphosphate-binding fold (THDP-binding)0.00002133Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.00005281Direct
Acyl-CoA dehydrogenase NM domain-like0.00005281Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00005281Direct
Terpenoid synthases0.000484Direct
Rudiment single hybrid motif0.000484Direct
Translation proteins0.01175Inherited
FAD/NAD(P)-binding domain0.9165Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
HCDH C-domain-like0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0000005858Direct
Biotinyl/lipoyl-carrier proteins and domains0.000004169Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.000004169Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.000004169Direct
Crotonase-like0.0001233Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0002309Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0.0002839Direct
BC C-terminal domain-like0.0002839Direct
Branched-chain alpha-keto acid dehydrogenase PP module0.0002839Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.6222Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
ClpP/crotonase0.000002769Direct
Single hybrid motif0.000003321Direct
Nucleotidylyl transferase0.000005754Direct
Thiamin diphosphate-binding fold (THDP-binding)0.000009687Direct
Acyl-CoA dehydrogenase NM domain-like0.00002477Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.00002477Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.00002477Direct
Terpenoid synthases0.0002513Direct
Rudiment single hybrid motif0.0002513Direct
Translation proteins0.007748Inherited
FAD/NAD(P)-binding domain0.8887Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.0000001122Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.00002477Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.0002513Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.0002513Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)