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Phenotypic Abnormality (PA): Abnormality of the respiratory system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the respiratory system [HP:0002086] <3>(30|35) (38|24|21)
- 1:   Functional respiratory abnormality [HP:0002795] <27>(10|13) (13|7|4)
- 1:   Abnormal respiratory system morphology [HP:0012252] <5>(20|25) (26|18|17)
- 1:   Neoplasm of the respiratory system [HP:0100606] <4>(1|0) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Tricorn protease domain 20Direct
Plakin repeat0Direct
Saposin0Direct
Lipoxigenase0Direct
Actin depolymerizing proteins0Direct
p53-like transcription factors0.0001419Direct
SH2 domain0.0001677Direct
4-helical cytokines0.01016Inherited
DEATH domain0.02235Inherited
Growth factor receptor domain0.02313Inherited
TB module/8-cys domain0.03546Inherited
Calcium-dependent phosphotriesterase0.07072Inherited
RuvA domain 2-like0.07072Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1274Inherited
Nicotinic receptor ligand binding domain-like0.1274Inherited
MHC antigen-recognition domain0.1584Inherited
GLA-domain0.1673Inherited
Cystine-knot cytokines0.2068Inherited
EGF/Laminin0.2543Inherited
TNF receptor-like0.2877Inherited
Ubiquitin-like0.3727Inherited
Snake toxin-like0.3915Inherited
Tropomyosin0.4753Inherited
RNA-binding domain, RBD0.4867Inherited
Intermediate filament protein, coiled coil region0.6372Inherited
ABC transporter transmembrane region0.7818Inherited
WD40 repeat-like0.8292Inherited
Voltage-gated potassium channels0.8658Inherited
vWA-like0.9295Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Filamin repeat (rod domain)0Direct
Animal lipoxigenases0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
beta-glycanases0Direct
Notch domain0Direct
Plakin repeat0Direct
SH2 domain0.00008414Direct
Growth factor receptor domain0.0001971Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0116Inherited
Transcription factor STAT-4 N-domain0.0116Inherited
Ras-binding domain, RBD0.0116Inherited
STAT DNA-binding domain0.0116Inherited
STAT0.0116Inherited
TB module/8-cys domain0.02549Inherited
DEATH domain, DD0.02912Inherited
C1 set domains (antibody constant domain-like)0.02912Inherited
VWC domain0.03837Inherited
ZZ domain0.0547Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1023Inherited
Nicotinic receptor ligand binding domain-like0.1023Inherited
Tetratricopeptide repeat (TPR)0.1183Inherited
Laminin-type module0.1235Inherited
MHC antigen-recognition domain0.1299Inherited
GLA-domain0.1384Inherited
MIR domain0.1384Inherited
Arylsulfatase0.2006Inherited
RecA protein-like (ATPase-domain)0.2006Inherited
Eukaryotic proteases0.3116Inherited
Canonical RBD0.3116Inherited
Tropomyosin0.4339Inherited
ABC transporter ATPase domain-like0.5788Inherited
Intermediate filament protein, coiled coil region0.5982Inherited
Integrin A (or I) domain0.7505Inherited
ABC transporter transmembrane region0.7552Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Saposin0Direct
Notch domain0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
Actin depolymerizing proteins0Direct
Lipoxigenase0Direct
p53-like transcription factors0.00006643Direct
SH2 domain0.00007915Direct
4-helical cytokines0.006545Inherited
Transcription factor STAT-4 N-domain0.0115Inherited
STAT0.0115Inherited
DEATH domain0.01537Inherited
Growth factor receptor domain0.01594Inherited
RCC1/BLIP-II0.01936Inherited
TB module/8-cys domain0.0253Inherited
Adenine nucleotide alpha hydrolases-like0.03787Inherited
RuvA domain 2-like0.05391Inherited
Calcium-dependent phosphotriesterase0.05391Inherited
Immunoglobulin0.08329Inherited
Nicotinic receptor ligand binding domain-like0.1023Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1023Inherited
MHC antigen-recognition domain0.1296Inherited
GLA-domain0.1375Inherited
MIR domain0.1375Inherited
Cystine-knot cytokines0.1736Inherited
Trypsin-like serine proteases0.2155Inherited
EGF/Laminin0.2171Inherited
TNF receptor-like0.2485Inherited
Ubiquitin-like0.3298Inherited
Snake toxin-like0.3482Inherited
Tropomyosin0.4314Inherited
RNA-binding domain, RBD0.4427Inherited
Intermediate filament protein, coiled coil region0.5961Inherited
ABC transporter transmembrane region0.7456Inherited
WD40 repeat-like0.7958Inherited
Voltage-gated potassium channels0.8343Inherited
vWA-like0.9024Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9605Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0115Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0115Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0115Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.0253Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0253Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.02738Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.07879Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.1023Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1296Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1338Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2156Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.299Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.7456Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002129Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0115Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0115Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0253Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0253Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03787Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04806Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.05391Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2932Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3382Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)