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Phenotypic Abnormality (PA): Abnormality of the respiratory system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the respiratory system [HP:0002086] <3>(28|34) (37|24|20)
- 1:   Functional respiratory abnormality [HP:0002795] <27>(10|13) (13|7|3)
- 1:   Abnormal respiratory system morphology [HP:0012252] <5>(18|24) (25|18|17)
- 1:   Neoplasm of the respiratory system [HP:0100606] <4>(1|0) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lipoxigenase0Direct
Notch domain0Direct
Actin depolymerizing proteins0Direct
Saposin0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
SH2 domain0.00005435Direct
p53-like transcription factors0.000225Direct
4-helical cytokines0.009246Inherited
Growth factor receptor domain0.01498Inherited
DEATH domain0.01975Inherited
TB module/8-cys domain0.03384Inherited
Calcium-dependent phosphotriesterase0.06841Inherited
RuvA domain 2-like0.06841Inherited
Nicotinic receptor ligand binding domain-like0.1201Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1201Inherited
MHC antigen-recognition domain0.1511Inherited
GLA-domain0.161Inherited
EGF/Laminin0.2333Inherited
TNF receptor-like0.2764Inherited
Ubiquitin-like0.3536Inherited
Snake toxin-like0.379Inherited
Intermediate filament protein, coiled coil region0.6173Inherited
RNA-binding domain, RBD0.6593Inherited
WD40 repeat-like0.7629Inherited
ABC transporter transmembrane region0.7703Inherited
Voltage-gated potassium channels0.8703Inherited
vWA-like0.8985Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
beta-glycanases0Direct
Plakin repeat0Direct
Filamin repeat (rod domain)0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Notch domain0Direct
Animal lipoxigenases0Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
SH2 domain0.00002739Direct
Growth factor receptor domain0.00005749Direct
Ras-binding domain, RBD0.01094Inherited
STAT DNA-binding domain0.01094Inherited
STAT0.01094Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.01094Inherited
Transcription factor STAT-4 N-domain0.01094Inherited
TB module/8-cys domain0.0244Inherited
DEATH domain, DD0.02723Inherited
C1 set domains (antibody constant domain-like)0.02723Inherited
VWC domain0.03655Inherited
ZZ domain0.0529Inherited
Nicotinic receptor ligand binding domain-like0.09635Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.09635Inherited
Laminin-type module0.1178Inherited
MHC antigen-recognition domain0.1247Inherited
MIR domain0.1339Inherited
GLA-domain0.1339Inherited
Tetratricopeptide repeat (TPR)0.1938Inherited
RecA protein-like (ATPase-domain)0.1942Inherited
Arylsulfatase0.1942Inherited
Eukaryotic proteases0.2955Inherited
Canonical RBD0.4883Inherited
ABC transporter ATPase domain-like0.5616Inherited
Intermediate filament protein, coiled coil region0.5794Inherited
Integrin A (or I) domain0.7394Inherited
ABC transporter transmembrane region0.7459Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lipoxigenase0Direct
Tricorn protease domain 20Direct
Plakin repeat0Direct
Actin depolymerizing proteins0Direct
Notch domain0Direct
Saposin0Direct
SH2 domain0.00002552Direct
p53-like transcription factors0.0001127Direct
4-helical cytokines0.005996Inherited
Growth factor receptor domain0.01006Inherited
Transcription factor STAT-4 N-domain0.01087Inherited
STAT0.01087Inherited
DEATH domain0.01354Inherited
RCC1/BLIP-II0.01831Inherited
TB module/8-cys domain0.02424Inherited
Adenine nucleotide alpha hydrolases-like0.03613Inherited
RuvA domain 2-like0.05231Inherited
Calcium-dependent phosphotriesterase0.05231Inherited
Nicotinic receptor ligand binding domain-like0.0962Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.0962Inherited
Immunoglobulin0.1031Inherited
MHC antigen-recognition domain0.1241Inherited
MIR domain0.1327Inherited
GLA-domain0.1327Inherited
Cystine-knot cytokines0.163Inherited
EGF/Laminin0.1986Inherited
Trypsin-like serine proteases0.2017Inherited
TNF receptor-like0.2393Inherited
Ubiquitin-like0.3128Inherited
Snake toxin-like0.3374Inherited
Intermediate filament protein, coiled coil region0.5772Inherited
RNA-binding domain, RBD0.6203Inherited
WD40 repeat-like0.7271Inherited
ABC transporter transmembrane region0.7346Inherited
Voltage-gated potassium channels0.8392Inherited
vWA-like0.8695Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9546Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01087Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01087Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01087Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.01186Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.02424Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02424Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.07449Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0962Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1241Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1299Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.201Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.2898Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2937Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.7346Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01087Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01087Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01831Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02424Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02424Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03613Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04543Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.05231Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.28Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4886Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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