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Phenotypic Abnormality (PA): Neurological speech impairment

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ + 2:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
+ 1:   Abnormality of higher mental function [HP:0011446] <9>(38|46) (42|25|8)
0:   Neurological speech impairment [HP:0002167] <20>(5|9) (6|4|1)
- 1:   Dysarthria [HP:0001260] <3>(2|5) (2|1|0)
- 1:   Dysphonia [HP:0001618] <2>(1|1) (1|0|0)
- 1:   Aphasia [HP:0002381] <1>(0|0) (0|0|0)
- 1:   Absent speech [HP:0001344](0|1) (1|0|0)
- 1:   Alexia [HP:0010523](0|0) (0|0|0)
- 1:   Anarthria [HP:0002425](0|0) (0|0|0)
- 1:   Anomia [HP:0030784](0|0) (0|0|0)
- 1:   Deficit in nonword repetition [HP:0002526](0|0) (0|0|0)
- 1:   Dysgraphia [HP:0010526](2|2) (2|1|0)
- 1:   Dysphasia [HP:0002357](0|1) (0|1|1)
- 1:   Echolalia [HP:0010529](0|0) (0|0|0)
- 1:   Grammar-specific speech disorder [HP:0006977](0|0) (0|0|0)
- 1:   Incomprehensible speech [HP:0002546](0|0) (0|0|0)
- 1:   Loss of speech [HP:0002371](0|0) (0|0|0)
- 1:   Mutism [HP:0002300](1|1) (1|1|0)
- 1:   Palilalia [HP:0031814](0|0) (0|0|0)
- 1:   Poor speech [HP:0002465](0|1) (0|0|0)
- 1:   Scanning speech [HP:0002168](0|0) (0|0|0)
- 1:   Stuttering [HP:0025268](0|0) (0|0|0)
- 1:   Tachylalia [HP:0031937](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.05397Inherited
SNARE fusion complex0.07471Inherited
Ribosomal protein S5 domain 2-like0.2263Inherited
RNA-binding domain, RBD0.3269Inherited
Intermediate filament protein, coiled coil region0.9647Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
IF2B-like0Direct
DNA gyrase/MutL, second domain0.00353Inherited
DNA gyrase/MutL, N-terminal domain0.00353Inherited
L-arabinose binding protein-like0.01721Inherited
SNARE fusion complex0.05348Inherited
Clathrin coat assembly domain0.09658Inherited
Canonical RBD0.2664Inherited
Complement control module/SCR domain0.5959Inherited
Intermediate filament protein, coiled coil region0.9413Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Periplasmic binding protein-like I0.02988Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.04047Inherited
SNARE fusion complex0.05764Inherited
Ribosomal protein S5 domain 2-like0.1919Inherited
RNA-binding domain, RBD0.2874Inherited
Intermediate filament protein, coiled coil region0.9405Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.003938Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.09176Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.489Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.2748Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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