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Phenotypic Abnormality (PA): Upper motor neuron dysfunction

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ + 2:   Abnormality of nervous system physiology [HP:0012638] <26>(104|120) (119|81|38)
+ 1:   Abnormality of central motor function [HP:0011442] <10>(18|24) (27|15|5)
0:   Upper motor neuron dysfunction [HP:0002493] <4>(8|14) (13|7|3)
- 1:   Abnormal pyramidal sign [HP:0007256] <5>(2|2) (2|1|0)
- 1:   Hypertonia [HP:0001276] <3>(5|9) (7|4|1)
- 1:   Weakness due to upper motor neuron dysfunction [HP:0010549] <3>(1|4) (4|2|2)
- 1:   Dysfunction of lateral corticospinal tracts [HP:0007299](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
ThrRS/AlaRS common domain0Direct
ADC-like0Direct
Ribonuclease PH domain 2-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Translation proteins0.001995Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02488Inherited
Cysteine proteinases0.575Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin domains from multidomain proteins0Direct
UBA domain0Direct
IF2B-like0Direct
Ribonuclease PH domain 1-like0Direct
Ribonuclease PH domain 2-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
L-arabinose binding protein-like0.000924Direct
DNA gyrase/MutL, second domain0.005715Inherited
DNA gyrase/MutL, N-terminal domain0.005715Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.07046Inherited
Extended AAA-ATPase domain0.09877Inherited
MHC antigen-recognition domain0.4259Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
ADC-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribonuclease PH domain 2-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
ThrRS/AlaRS common domain0Direct
Translation proteins0.001138Inherited
NagB/RpiA/CoA transferase-like0.008216Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.01735Inherited
4Fe-4S ferredoxins0.01894Inherited
Ribonuclease H-like0.02461Inherited
HAD-like0.2981Inherited
MHC antigen-recognition domain0.434Inherited
Cysteine proteinases0.5331Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001741Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.006405Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.008216Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.434Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2139Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3433Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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