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Phenotypic Abnormality (PA): Neoplasm

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Neoplasm [HP:0002664] <2>(20|24) (24|8|3)
- 1:   Neoplasm by anatomical site [HP:0011793] <24>(18|21) (21|7|2)
- 1:   Neoplasm by histology [HP:0011792] <7>(5|9) (6|3|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DNA-glycosylase0Direct
SH2 domain0.00001377Direct
Protein kinase-like (PK-like)0.0001037Direct
TNF receptor-like0.01073Inherited
DNA repair protein MutS, domain III0.01347Inherited
Ribosomal protein S5 domain 2-like0.01812Inherited
DEATH domain0.01835Inherited
Sema domain0.02118Inherited
Snake toxin-like0.02506Inherited
DNA/RNA polymerases0.02886Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03527Inherited
Ribonuclease H-like0.03729Inherited
BRCT domain0.07619Inherited
Plexin repeat0.1001Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1358Inherited
Ubiquitin-like0.1392Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2444Inherited
Nuclear receptor ligand-binding domain0.2594Inherited
Intermediate filament protein, coiled coil region0.2755Inherited
(Phosphotyrosine protein) phosphatases II0.3397Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
DIX domain0Direct
DNA gyrase/MutL, second domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
SH2 domain0.00001129Direct
Protein kinases, catalytic subunit0.000179Direct
Tandem AAA-ATPase domain0.004609Inherited
RecA protein-like (ATPase-domain)0.006312Inherited
DNA repair protein MutS, domain III0.01007Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01007Inherited
Sema domain0.01689Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.04173Inherited
POU-specific domain0.0592Inherited
Ras-binding domain, RBD0.0592Inherited
Plexin repeat0.08895Inherited
FHA domain0.0944Inherited
RING finger domain, C3HC40.1152Inherited
DEATH domain, DD0.116Inherited
Ran binding protein zinc finger-like0.137Inherited
PHD domain0.1637Inherited
PLC-like (P variant)0.1789Inherited
Laminin-type module0.203Inherited
Nuclear receptor ligand-binding domain0.2481Inherited
Intermediate filament protein, coiled coil region0.2678Inherited
ABC transporter ATPase domain-like0.3432Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DNA-glycosylase0Direct
SH2 domain0.000006151Direct
Protein kinase-like (PK-like)0.0000497Direct
TNF receptor-like0.007029Inherited
DNA repair protein MutS, domain III0.008976Inherited
Ribosomal protein S5 domain 2-like0.01231Inherited
DEATH domain0.01249Inherited
Sema domain0.0146Inherited
Snake toxin-like0.01747Inherited
DNA/RNA polymerases0.02033Inherited
RING/U-box0.02394Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0254Inherited
p53-like transcription factors0.02577Inherited
Ribonuclease H-like0.02699Inherited
BRCT domain0.0589Inherited
Plexin repeat0.07926Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1104Inherited
Ubiquitin-like0.1136Inherited
Ran binding protein zinc finger-like0.1265Inherited
lambda repressor-like DNA-binding domains0.1695Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2091Inherited
Nuclear receptor ligand-binding domain0.223Inherited
Intermediate filament protein, coiled coil region0.2384Inherited
(Phosphotyrosine protein) phosphatases II0.2995Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0001337Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.005285Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.008976Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.008976Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.008976Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.0146Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3545Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000586Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1962Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2153Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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