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Phenotypic Abnormality (PA): Neoplasm

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Neoplasm [HP:0002664] <2>(20|21) (23|8|3)
- 1:   Neoplasm by anatomical site [HP:0011793] <24>(18|19) (20|7|2)
- 1:   Neoplasm by histology [HP:0011792] <7>(5|7) (6|3|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DNA-glycosylase0Direct
SH2 domain0.00002797Direct
Protein kinase-like (PK-like)0.00009834Direct
TNF receptor-like0.01102Inherited
DNA repair protein MutS, domain III0.0137Inherited
DEATH domain0.01881Inherited
Sema domain0.02148Inherited
Snake toxin-like0.02537Inherited
Ribosomal protein S5 domain 2-like0.02657Inherited
DNA/RNA polymerases0.02925Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03578Inherited
Ribonuclease H-like0.03793Inherited
BRCT domain0.07685Inherited
Plexin repeat0.1014Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.138Inherited
Ubiquitin-like0.1412Inherited
Nuclear receptor ligand-binding domain0.2626Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2721Inherited
Intermediate filament protein, coiled coil region0.2793Inherited
(Phosphotyrosine protein) phosphatases II0.3434Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA gyrase/MutL, second domain0Direct
DIX domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
SH2 domain0.00002279Direct
Protein kinases, catalytic subunit0.0001409Direct
RecA protein-like (ATPase-domain)0.006439Inherited
DNA repair protein MutS, domain III0.01018Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01018Inherited
Sema domain0.01717Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.04224Inherited
POU-specific domain0.05974Inherited
Ras-binding domain, RBD0.05974Inherited
Plexin repeat0.09024Inherited
FHA domain0.09554Inherited
RING finger domain, C3HC40.1171Inherited
DEATH domain, DD0.1176Inherited
Ran binding protein zinc finger-like0.1384Inherited
Laminin-type module0.205Inherited
ABC transporter ATPase domain-like0.2209Inherited
Nuclear receptor ligand-binding domain0.2515Inherited
Intermediate filament protein, coiled coil region0.2713Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DNA-glycosylase0Direct
SH2 domain0.00001228Direct
Protein kinase-like (PK-like)0.00004537Direct
TNF receptor-like0.007116Inherited
DNA repair protein MutS, domain III0.009051Inherited
DEATH domain0.0127Inherited
Sema domain0.0147Inherited
Snake toxin-like0.01757Inherited
RING/U-box0.01806Inherited
Ribosomal protein S5 domain 2-like0.01844Inherited
DNA/RNA polymerases0.02049Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02557Inherited
Ribonuclease H-like0.0272Inherited
BRCT domain0.05902Inherited
Plexin repeat0.07975Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1117Inherited
Ubiquitin-like0.1146Inherited
Ran binding protein zinc finger-like0.1272Inherited
lambda repressor-like DNA-binding domains0.1703Inherited
Nuclear receptor ligand-binding domain0.2249Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2339Inherited
Intermediate filament protein, coiled coil region0.2408Inherited
(Phosphotyrosine protein) phosphatases II0.3019Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0007428Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.005351Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.009051Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.009051Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.009051Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.0147Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3572Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000593Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1974Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2165Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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