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Phenotypic Abnormality (PA): Abnormality of the immune system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
- 1:   Abnormality of immune system physiology [HP:0010978] <14>(29|37) (31|22|11)
- 1:   Abnormality of the lymphatic system [HP:0100763] <7>(9|19) (15|8|5)
- 1:   Abnormal immune system morphology [HP:0032251] <3>(11|11) (11|6|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Tricorn protease domain 20Direct
Anaphylotoxins (complement system)0Direct
Restriction endonuclease-like0Direct
SAND domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Lipoxigenase0Direct
DEATH domain0.000005317Direct
Immunoglobulin0.0002942Direct
MHC antigen-recognition domain0.0003874Direct
SH2 domain0.003434Inherited
Complement control module/SCR domain0.003814Inherited
TNF-like0.008721Inherited
ABC transporter transmembrane region0.008721Inherited
p53-like transcription factors0.009081Inherited
DNA/RNA polymerases0.009564Inherited
RNI-like0.0104Inherited
4-helical cytokines0.01265Inherited
(Trans)glycosidases0.01334Inherited
Globin-like0.01973Inherited
TNF receptor-like0.02714Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.05807Inherited
Caspase-like0.07737Inherited
Transcription factor STAT-4 N-domain0.1024Inherited
STAT0.1024Inherited
Alpha-macroglobulin receptor domain0.1132Inherited
Fibrinogen C-terminal domain-like0.1174Inherited
Terpenoid cyclases/Protein prenyltransferases0.1174Inherited
Trypsin-like serine proteases0.1402Inherited
TIMP-like0.181Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2714Inherited
Cysteine-rich domain0.3617Inherited
TSP-1 type 1 repeat0.3721Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4011Inherited
FYVE/PHD zinc finger0.4691Inherited
SH3-domain0.4864Inherited
LDL receptor-like module0.6874Inherited
Spermadhesin, CUB domain0.7057Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Animal lipoxigenases0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
Netrin-like domain (NTR/C345C module)0Direct
beta-glycanases0Direct
ets domain0Direct
Notch domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Anaphylotoxins (complement system)0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Long-chain cytokines0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0Direct
Fibrinogen coiled-coil and central regions0Direct
C1 set domains (antibody constant domain-like)0.00001626Direct
MHC antigen-recognition domain0.0002453Direct
DEATH domain, DD0.002435Inherited
SH2 domain0.002581Inherited
Complement control module/SCR domain0.002772Inherited
ABC transporter ATPase domain-like0.004136Inherited
TNF-like0.006461Inherited
ABC transporter transmembrane region0.009402Inherited
Globins0.01472Inherited
Ras-binding domain, RBD0.01472Inherited
Pyrin domain, PYD0.0308Inherited
28-residue LRR0.03201Inherited
PX domain0.04738Inherited
TNF receptor-like0.06209Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.06365Inherited
Tandem AAA-ATPase domain0.07142Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.08626Inherited
Nitrogenase iron protein-like0.08626Inherited
Transcription factor STAT-4 N-domain0.08626Inherited
STAT DNA-binding domain0.08626Inherited
STAT0.08626Inherited
Alpha-macroglobulin receptor domain0.0968Inherited
Complement components0.0968Inherited
Fibrinogen C-terminal domain-like0.1009Inherited
Arylsulfatase0.1009Inherited
Caspase recruitment domain, CARD0.1528Inherited
Eukaryotic proteases0.1863Inherited
PLC-like (P variant)0.2531Inherited
Tetratricopeptide repeat (TPR)0.2551Inherited
PHD domain0.2551Inherited
Noncollagenous (NC1) domain of collagen IV0.2576Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2915Inherited
TSP-1 type 1 repeat0.3514Inherited
V set domains (antibody variable domain-like)0.3656Inherited
RecA protein-like (ATPase-domain)0.4324Inherited
SH3-domain0.5399Inherited
LDL receptor-like module0.675Inherited
Spermadhesin, CUB domain0.6907Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Notch domain0Direct
Tricorn protease domain 20Direct
Anaphylotoxins (complement system)0Direct
Restriction endonuclease-like0Direct
SAND domain-like0Direct
Lipoxigenase0Direct
DEATH domain0.000002201Direct
Immunoglobulin0.0001447Direct
MHC antigen-recognition domain0.0001929Direct
SH2 domain0.002016Inherited
Complement control module/SCR domain0.002255Inherited
ABC transporter transmembrane region0.005562Inherited
TNF-like0.005562Inherited
p53-like transcription factors0.005806Inherited
DNA/RNA polymerases0.006134Inherited
RNI-like0.006702Inherited
4-helical cytokines0.008285Inherited
(Trans)glycosidases0.00879Inherited
Globin-like0.01339Inherited
TNF receptor-like0.01888Inherited
PX domain0.04345Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.04345Inherited
Caspase-like0.05941Inherited
Transcription factor STAT-4 N-domain0.08052Inherited
STAT0.08052Inherited
Alpha-macroglobulin receptor domain0.08958Inherited
Fibrinogen C-terminal domain-like0.09334Inherited
Terpenoid cyclases/Protein prenyltransferases0.09334Inherited
Trypsin-like serine proteases0.1137Inherited
TIMP-like0.1499Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2333Inherited
Cysteine-rich domain0.3194Inherited
TSP-1 type 1 repeat0.3293Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.3578Inherited
Snake toxin-like0.3775Inherited
FYVE/PHD zinc finger0.4254Inherited
SH3-domain0.4424Inherited
LDL receptor-like module0.6482Inherited
Spermadhesin, CUB domain0.6667Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    82895,57424
  • 82895 - TSP-1 type 1 repeat
  • 57424 - LDL receptor-like module
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.00009058Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0001929Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.005562Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.005646Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0115Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02855Inherited
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.05941Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.05941Inherited
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.05941Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.05941Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.08052Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.08052Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.08052Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1454Inherited
    49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0.1454Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.1454Inherited
    57196,49854
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.2467Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.4566Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0004798Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.05941Inherited
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.05941Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05941Inherited
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.05941Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.08052Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.08052Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.08052Inherited
    49854,57196,49854
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.1454Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2343Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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