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Phenotypic Abnormality (PA): Abnormality of the immune system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the immune system [HP:0002715] <3>(37|52) (39|28|15)
- 1:   Abnormality of immune system physiology [HP:0010978] <14>(29|40) (31|23|11)
- 1:   Abnormality of the lymphatic system [HP:0100763] <7>(10|17) (14|6|4)
- 1:   Abnormal immune system morphology [HP:0032251] <3>(9|10) (9|6|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lipoxigenase0Direct
Notch domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Restriction endonuclease-like0Direct
Tricorn protease domain 20Direct
Anaphylotoxins (complement system)0Direct
SAND domain-like0Direct
DEATH domain0.000004996Direct
Immunoglobulin0.0002919Direct
MHC antigen-recognition domain0.0003742Direct
SH2 domain0.001883Inherited
Complement control module/SCR domain0.003698Inherited
RNI-like0.004588Inherited
TNF-like0.008531Inherited
ABC transporter transmembrane region0.008531Inherited
DNA/RNA polymerases0.009413Inherited
4-helical cytokines0.01239Inherited
(Trans)glycosidases0.01304Inherited
p53-like transcription factors0.01392Inherited
Globin-like0.01951Inherited
TNF receptor-like0.02679Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.05739Inherited
Caspase-like0.07695Inherited
Transcription factor STAT-4 N-domain0.1015Inherited
STAT0.1015Inherited
Alpha-macroglobulin receptor domain0.1122Inherited
Terpenoid cyclases/Protein prenyltransferases0.1163Inherited
TIMP-like0.1799Inherited
Trypsin-like serine proteases0.2075Inherited
Fibrinogen C-terminal domain-like0.2555Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2679Inherited
Cysteine-rich domain0.3589Inherited
TSP-1 type 1 repeat0.3691Inherited
SH3-domain0.4082Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4663Inherited
Spermadhesin, CUB domain0.6405Inherited
LDL receptor-like module0.7701Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
beta-glycanases0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
Proteasome subunits0Direct
Anaphylotoxins (complement system)0Direct
Long-chain cytokines0Direct
XPF/Rad1/Mus81 nuclease0Direct
ets domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Notch domain0Direct
Animal lipoxigenases0Direct
Netrin-like domain (NTR/C345C module)0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0Direct
C1 set domains (antibody constant domain-like)0.00001596Direct
MHC antigen-recognition domain0.000242Direct
SH2 domain0.001391Inherited
DEATH domain, DD0.002402Inherited
Complement control module/SCR domain0.002736Inherited
ABC transporter ATPase domain-like0.004082Inherited
TNF-like0.006403Inherited
ABC transporter transmembrane region0.009328Inherited
Ras-binding domain, RBD0.01464Inherited
Globins0.01464Inherited
Laminin-type module0.02104Inherited
Pyrin domain, PYD0.03072Inherited
28-residue LRR0.03186Inherited
TNF receptor-like0.06198Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.0636Inherited
I set domains0.07821Inherited
STAT DNA-binding domain0.0859Inherited
STAT0.0859Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0859Inherited
Transcription factor STAT-4 N-domain0.0859Inherited
Nitrogenase iron protein-like0.0859Inherited
Alpha-macroglobulin receptor domain0.09616Inherited
Complement components0.09616Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.09616Inherited
Arylsulfatase0.1003Inherited
Caspase recruitment domain, CARD0.1525Inherited
PLC-like (P variant)0.1958Inherited
PHD domain0.2071Inherited
Fibrinogen C-terminal domain-like0.233Inherited
Tetratricopeptide repeat (TPR)0.2538Inherited
Noncollagenous (NC1) domain of collagen IV0.2567Inherited
Eukaryotic proteases0.2752Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2895Inherited
TSP-1 type 1 repeat0.3503Inherited
V set domains (antibody variable domain-like)0.3638Inherited
RecA protein-like (ATPase-domain)0.4308Inherited
SH3-domain0.4598Inherited
Spermadhesin, CUB domain0.6236Inherited
LDL receptor-like module0.761Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SAND domain-like0Direct
Lipoxigenase0Direct
Tricorn protease domain 20Direct
Anaphylotoxins (complement system)0Direct
Restriction endonuclease-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Notch domain0Direct
DEATH domain0.00000217Direct
Immunoglobulin0.000148Direct
MHC antigen-recognition domain0.0001921Direct
Actin-like ATPase domain0.0009762Direct
SH2 domain0.00107Inherited
Complement control module/SCR domain0.002226Inherited
RNI-like0.00281Inherited
ABC transporter transmembrane region0.005505Inherited
TNF-like0.005505Inherited
DNA/RNA polymerases0.006109Inherited
4-helical cytokines0.008219Inherited
(Trans)glycosidases0.008674Inherited
p53-like transcription factors0.009307Inherited
Globin-like0.01336Inherited
TNF receptor-like0.01878Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.04324Inherited
Caspase-like0.05944Inherited
Transcription factor STAT-4 N-domain0.08029Inherited
STAT0.08029Inherited
Alpha-macroglobulin receptor domain0.08933Inherited
Terpenoid cyclases/Protein prenyltransferases0.09294Inherited
TIMP-like0.1495Inherited
Trypsin-like serine proteases0.1749Inherited
Fibrinogen C-terminal domain-like0.2193Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2313Inherited
Cysteine-rich domain0.3179Inherited
TSP-1 type 1 repeat0.3276Inherited
SH3-domain0.3659Inherited
Snake toxin-like0.3759Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4232Inherited
Spermadhesin, CUB domain0.6011Inherited
LDL receptor-like module0.7345Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
82895,57424
  • 82895 - TSP-1 type 1 repeat
  • 57424 - LDL receptor-like module
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.00009012Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0001921Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.005505Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.005621Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01141Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0285Inherited
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.05944Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.05944Inherited
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.05944Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.08029Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.08029Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.08029Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1451Inherited
    49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0.1451Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.1451Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1506Inherited
    57196,49854
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.2451Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.4551Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.000478Direct
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.05944Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.05944Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05944Inherited
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.05944Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.08029Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.08029Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.08029Inherited
    49854,57196,49854
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.1451Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2335Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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