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Phenotypic Abnormality (PA): Functional respiratory abnormality

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the respiratory system [HP:0002086] <3>(28|34) (37|24|20)
0:   Functional respiratory abnormality [HP:0002795] <27>(10|13) (13|7|3)
- 1:   Abnormal pattern of respiration [HP:0002793] <9>(1|4) (1|1|1)
- 1:   Respiratory insufficiency [HP:0002093] <8>(2|4) (3|1|0)
- 1:   Abnormal breath sound [HP:0030829] <6>(0|0) (0|0|0)
- 1:   Abnormality of pulmonary circulation [HP:0030875] <6>(1|1) (1|0|1)
- 1:   Dyspnea [HP:0002094] <4>(3|3) (4|1|0)
- 1:   Weakness of muscles of respiration [HP:0004347] <4>(1|0) (1|2|0)
- 1:   Asthma [HP:0002099] <3>(0|0) (0|0|0)
- 1:   Cough [HP:0012735] <3>(1|2) (1|1|0)
- 1:   Cyanosis [HP:0000961] <3>(0|0) (0|0|0)
- 1:   Obstructive lung disease [HP:0006536] <3>(0|1) (0|0|1)
- 1:   Abnormal blood gas level [HP:0012415] <2>(0|0) (0|0|0)
- 1:   Abnormal respiratory motile cilium physiology [HP:0012261] <2>(0|1) (0|0|1)
- 1:   Abnormality on pulmonary function testing [HP:0030878] <2>(0|0) (0|0|0)
- 1:   Breathing dysregulation [HP:0005957] <2>(0|0) (0|0|0)
- 1:   Abnormal bronchus physiology [HP:0025427] <1>(0|0) (0|0|0)
- 1:   Abnormal mucociliary clearance [HP:0031602] <1>(0|1) (0|0|1)
- 1:   Abnormal nasal mucus secretion [HP:0031416] <1>(0|0) (0|0|0)
- 1:   Abnormal response to short acting pulmonary vasodilator [HP:0030893] <1>(0|0) (0|0|0)
- 1:   Decreased pulmonary function [HP:0005952] <1>(0|0) (0|0|0)
- 1:   Restrictive ventilatory defect [HP:0002091] <1>(0|1) (1|1|0)
- 1:   Sneeze [HP:0025095] <1>(0|0) (0|0|0)
- 1:   Snoring [HP:0025267] <1>(0|0) (0|0|0)
- 1:   Upper airway obstruction [HP:0002781] <1>(0|0) (1|1|1)
- 1:   Aspiration [HP:0002835](0|0) (0|0|0)
- 1:   Recurrent singultus [HP:0100247](0|0) (0|0|0)
- 1:   Reduced vital capacity [HP:0002792](2|2) (2|1|0)
- 1:   Tracheal tug on inspiration [HP:0025008](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Saposin0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
Nicotinic receptor ligand binding domain-like0.01735Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.01735Inherited
Calcium-dependent phosphotriesterase0.02655Inherited
GLA-domain0.05902Inherited
MHC antigen-recognition domain0.262Inherited
Voltage-gated potassium channels0.5975Inherited
vWA-like0.8268Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Plakin repeat0Direct
Filamin repeat (rod domain)0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Nicotinic receptor ligand binding domain-like0.01074Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.01074Inherited
ZZ domain0.01793Inherited
Laminin-type module0.02237Inherited
GLA-domain0.0432Inherited
MHC antigen-recognition domain0.2147Inherited
MIR domain0.3578Inherited
Tetratricopeptide repeat (TPR)0.4267Inherited
C1 set domains (antibody constant domain-like)0.5661Inherited
Integrin A (or I) domain0.5738Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Tricorn protease domain 20Direct
Plakin repeat0Direct
Saposin0Direct
Adenine nucleotide alpha hydrolases-like0.008002Inherited
Nicotinic receptor ligand binding domain-like0.01177Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.01177Inherited
Calcium-dependent phosphotriesterase0.01858Inherited
GLA-domain0.04462Inherited
MHC antigen-recognition domain0.2256Inherited
MIR domain0.3689Inherited
Voltage-gated potassium channels0.5562Inherited
Immunoglobulin0.6131Inherited
vWA-like0.7938Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.01177Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.0517Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.1167Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2256Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3643Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.134Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2256Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.7373Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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