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Phenotypic Abnormality (PA): Aplasia/Hypoplasia involving the central nervous system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(147|170) (164|102|45)
+ + 2:   Abnormality of nervous system morphology [HP:0012639] <5>(70|97) (81|48|16)
+ 1:   Morphological abnormality of the central nervous system [HP:0002011] <17>(61|85) (71|41|16)
0:   Aplasia/Hypoplasia involving the central nervous system [HP:0002977] <13>(18|22) (22|10|2)
- 1:   Aplasia/Hypoplasia of the cerebrum [HP:0007364] <5>(11|15) (12|5|1)
- 1:   Atrophy/Degeneration affecting the cerebrum [HP:0007369] <5>(1|3) (2|2|0)
- 1:   Aplasia/Hypoplasia of the cerebellum [HP:0007360] <2>(0|1) (1|1|0)
- 1:   Aplasia/Hypoplasia of the optic tract [HP:0011000] <2>(0|0) (0|0|0)
- 1:   Aplasia/Hypoplasia of the pyramidal tract [HP:0007363] <2>(0|0) (0|0|0)
- 1:   Aplasia/Hypoplasia involving the corticospinal tracts [HP:0007365] <1>(0|0) (0|0|0)
- 1:   Aplasia/Hypoplasia of the brainstem [HP:0007362] <1>(2|2) (3|1|0)
- 1:   Optic nerve hypoplasia [HP:0000609] <1>(1|1) (1|0|0)
- 1:   Agenesis of pineal gland [HP:0012687](0|0) (0|0|0)
- 1:   Global brain atrophy [HP:0002283](0|0) (0|0|0)
- 1:   Hypoplasia of olfactory tract [HP:0007036](0|0) (0|0|0)
- 1:   Hypoplasia of the olfactory bulb [HP:0040326](0|0) (0|0|0)
- 1:   Hypoplastic olfactory lobes [HP:0006894](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
Pseudouridine synthase0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
ADC-like0Direct
Restriction endonuclease-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
WD40 repeat-like0.0001872Direct
ARID-like0.009318Inherited
Tubulin nucleotide-binding domain-like0.0371Inherited
Tubulin C-terminal domain-like0.05317Inherited
Nucleotidylyl transferase0.05993Inherited
Actin-like ATPase domain0.1869Inherited
NagB/RpiA/CoA transferase-like0.1986Inherited
Homeodomain-like0.3422Inherited
Ribonuclease H-like0.3988Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin domains from multidomain proteins0Direct
Smc hinge domain0Direct
IF2B-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
Histone deacetylase, HDAC0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
N-acetyl transferase, NAT0Direct
Clathrin adaptor core protein0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
SWIRM domain0Direct
Protein serine/threonine phosphatase0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.003833Inherited
ARID domain0.004922Inherited
Bromodomain0.01407Inherited
Tubulin, GTPase domain0.02121Inherited
Tubulin, C-terminal domain0.0321Inherited
PHD domain0.09274Inherited
MIR domain0.2289Inherited
Homeodomain0.3793Inherited
PDZ domain0.4523Inherited
T-box0.5567Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
ADC-like0Direct
Smc hinge domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Pseudouridine synthase0Direct
Restriction endonuclease-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
WD40 repeat-like0.00009243Direct
ARID-like0.006044Inherited
Bromodomain0.01841Inherited
Tubulin nucleotide-binding domain-like0.02682Inherited
Tubulin C-terminal domain-like0.03981Inherited
Nucleotidylyl transferase0.0454Inherited
Nucleotide-diphospho-sugar transferases0.1552Inherited
Actin-like ATPase domain0.156Inherited
NagB/RpiA/CoA transferase-like0.1668Inherited
PDZ domain-like0.212Inherited
MIR domain0.2484Inherited
Homeodomain-like0.302Inherited
Ribonuclease H-like0.3567Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.02155Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.03981Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.2075Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.3581Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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