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Phenotypic Abnormality (PA): Abnormality of urine homeostasis

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Abnormality of the genitourinary system [HP:0000119] <5>(74|72) (79|29|9)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the urinary system [HP:0000079] <4>(38|40) (44|16|7)
+ 1:   Abnormality of the urinary system physiology [HP:0011277] <3>(22|25) (26|9|5)
+ 1:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(76|83) (79|38|16)
0:   Abnormality of urine homeostasis [HP:0003110] <58>(17|20) (20|7|3)
- 1:   Abnormal urine carbohydrate level [HP:0031979] <12>(0|0) (0|0|0)
- 1:   Abnormal urinary color [HP:0012086] <9>(0|0) (0|0|0)
- 1:   Abnormal urinary electrolyte concentration [HP:0012591] <7>(1|3) (4|1|0)
- 1:   Abnormal urine protein level [HP:0020129] <7>(0|1) (0|0|0)
- 1:   Crystalluria [HP:0020074] <6>(0|0) (0|0|0)
- 1:   Abnormal urine carboxylic acid level [HP:0031980] <5>(0|0) (0|0|0)
- 1:   Abnormal urine cytology [HP:0012614] <5>(5|7) (5|5|3)
- 1:   Aciduria [HP:0012072] <3>(8|7) (8|1|0)
- 1:   Abnormal urinary 1-methylhistidine concentration [HP:0410313] <2>(0|0) (0|0|0)
- 1:   Abnormal urinary 3-methylhistidine concentration [HP:0410316] <2>(0|0) (0|0|0)
- 1:   Abnormal urinary mineral level [HP:0025640] <2>(0|0) (0|0|0)
- 1:   Abnormal urinary sulfate concentration [HP:0012612] <2>(0|0) (0|0|0)
- 1:   Abnormal urine alpha-ketoglutarate concentration [HP:0012401] <2>(0|0) (0|0|0)
- 1:   Abnormal urine citrate concentration [HP:0012404] <2>(0|0) (0|0|0)
- 1:   Abnormal urine urobilinogen level [HP:0032472] <2>(0|0) (0|0|0)
- 1:   Abnormality of urinary uric acid concentration [HP:0012610] <2>(0|0) (0|0|0)
- 1:   Abnormality of urine bicarbonate concentration [HP:0011279] <2>(0|0) (0|0|0)
- 1:   Abnormality of urine catecholamine concentration [HP:0011281] <2>(0|0) (0|0|0)
- 1:   Glycopeptiduria [HP:0012067] <2>(0|0) (0|0|0)
- 1:   Myoglobinuria [HP:0002913] <2>(0|0) (0|0|0)
- 1:   Abnormal urinary acylglycine profile [HP:0012073] <1>(0|0) (0|0|0)
- 1:   Abnormal urine hexanoylglycine concentration [HP:0500254] <1>(0|0) (0|0|0)
- 1:   Abnormal urine sebacic acid concentration [HP:0500251] <1>(0|0) (0|0|0)
- 1:   Abnormality of urine glucose concentration [HP:0011016] <1>(0|0) (0|0|0)
- 1:   Hemoglobinuria [HP:0003641] <1>(0|0) (0|0|0)
- 1:   Urinary glycosaminoglycan excretion [HP:0003541] <1>(2|1) (2|0|0)
- 1:   Abnormal concentration of acylcarnitine in the urine [HP:0500170](0|0) (0|0|0)
- 1:   Abnormal urinary odor [HP:0012088](0|0) (0|0|0)
- 1:   Absent urinary urothione [HP:0003606](0|0) (0|0|0)
- 1:   Bacteriuria [HP:0012461](0|0) (0|0|0)
- 1:   Bilirubinuria [HP:0031811](0|0) (0|0|0)
- 1:   Cloudy urine [HP:0031967](0|0) (0|0|0)
- 1:   Elevated urinary N-acetylaspartic acid level [HP:0032272](0|0) (0|0|0)
- 1:   Elevated urinary delta-aminolevulinic acid [HP:0003163](0|0) (0|0|0)
- 1:   Elevated urine pyrophosphate [HP:0003491](0|0) (0|0|0)
- 1:   Foamy urine [HP:0031504](0|0) (0|0|0)
- 1:   Hemosiderinuria [HP:0012543](0|0) (0|0|0)
- 1:   Hyperprostaglandinuria [HP:0003527](0|0) (0|0|0)
- 1:   Hyperuricosuria [HP:0003149](0|0) (0|0|0)
- 1:   Hyposthenuria [HP:0003158](0|0) (0|0|0)
- 1:   Increased level of N-acetylneuraminic acid in urine [HP:0410156](0|0) (0|0|0)
- 1:   Increased level of O-phosphoethanolamine in urine [HP:0410158](0|0) (0|0|0)
- 1:   Increased urinary excretion of galactosyl hydroxylysine [HP:0031991](0|0) (0|0|0)
- 1:   Increased urinary hypoxanthine [HP:0011814](0|0) (0|0|0)
- 1:   Increased urinary mucus [HP:0032068](0|0) (0|0|0)
- 1:   Increased urinary porphobilinogen [HP:0012217](0|0) (0|0|0)
- 1:   Increased urinary sulfite [HP:0011942](0|0) (0|0|0)
- 1:   Increased urinary thiosulfate [HP:0011943](0|0) (0|0|0)
- 1:   Increased urinary type 1 collagen N-terminal telopeptide level [HP:0032208](0|0) (0|0|0)
- 1:   Ketonuria [HP:0002919](0|0) (0|0|0)
- 1:   Lipiduria [HP:0032567](0|0) (0|0|0)
- 1:   Low urinary cyclic AMP response to PTH administration [HP:0003456](0|0) (0|0|0)
- 1:   Nitrituria [HP:0031812](0|0) (0|0|0)
- 1:   Parathormone-independent increased renal tubular calcium reabsorption [HP:0003529](0|0) (0|0|0)
- 1:   Porphyrinuria [HP:0010473](0|0) (0|0|0)
- 1:   Trimethylaminuria [HP:0003614](0|0) (0|0|0)
- 1:   Uraciluria [HP:0012127](0|0) (0|0|0)
- 1:   Xanthinuria [HP:0010934](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
PRTase-like0Direct
L-aspartase-like0.004457Inherited
ClpP/crotonase0.00717Inherited
Adenine nucleotide alpha hydrolases-like0.01315Inherited
(Trans)glycosidases0.01636Inherited
Alkaline phosphatase-like0.01705Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.01705Inherited
Acyl-CoA dehydrogenase NM domain-like0.01705Inherited
Glutathione synthetase ATP-binding domain-like0.01729Inherited
PreATP-grasp domain0.03914Inherited
C-type lectin-like0.06192Inherited
Transcription factor STAT-4 N-domain0.08389Inherited
STAT0.08389Inherited
Clc chloride channel0.08389Inherited
Mitochondrial carrier0.1465Inherited
Complement control module/SCR domain0.1596Inherited
L domain-like0.5532Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
beta-glycanases0Direct
HCDH C-domain-like0Direct
Phosphoribosyltransferases (PRTases)0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.002219Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.002219Inherited
Noncollagenous (NC1) domain of collagen IV0.002599Inherited
Cytoplasmic domain of inward rectifier potassium channel0.003712Inherited
Arylsulfatase0.0142Inherited
Cystathionine synthase-like0.02738Inherited
Crotonase-like0.02738Inherited
BC ATP-binding domain-like0.07394Inherited
STAT DNA-binding domain0.07394Inherited
STAT0.07394Inherited
Clc chloride channel0.07394Inherited
BC N-terminal domain-like0.07394Inherited
Transcription factor STAT-4 N-domain0.07394Inherited
Cytochrome P4500.1267Inherited
Mitochondrial carrier0.1371Inherited
Complement control module/SCR domain0.1528Inherited
Ngr ectodomain-like0.35Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PRTase-like0Direct
L-aspartase-like0.002724Inherited
ClpP/crotonase0.004567Inherited
Adenine nucleotide alpha hydrolases-like0.008765Inherited
(Trans)glycosidases0.01106Inherited
Acyl-CoA dehydrogenase NM domain-like0.01155Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.01155Inherited
Alkaline phosphatase-like0.01155Inherited
Glutathione synthetase ATP-binding domain-like0.01172Inherited
CBS-domain pair0.02758Inherited
PreATP-grasp domain0.02836Inherited
C-type lectin-like0.04699Inherited
Clc chloride channel0.06522Inherited
Transcription factor STAT-4 N-domain0.06522Inherited
STAT0.06522Inherited
Mitochondrial carrier0.1199Inherited
Complement control module/SCR domain0.1316Inherited
Cytochrome P4500.1396Inherited
L domain-like0.5109Inherited
Voltage-gated potassium channels0.806Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.002887Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.01059Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.01155Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.06522Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.06522Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.06522Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.08153Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.06522Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.06522Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.09955Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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