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Phenotypic Abnormality (PA): Abnormal circulating hormone level

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the endocrine system [HP:0000818] <16>(30|34) (35|12|5)
0:   Abnormal circulating hormone level [HP:0003117] <28>(4|9) (6|4|1)
- 1:   Abnormal calcium-phosphate regulating hormone level [HP:0100530] <4>(0|0) (0|0|0)
- 1:   Abnormal circulating androgen level [HP:0030347] <4>(0|0) (0|0|0)
- 1:   Abnormal circulating gonadotropin level [HP:0030338] <4>(0|0) (0|0|0)
- 1:   Abnormal circulating estrogen level [HP:0025132] <3>(0|0) (1|0|0)
- 1:   Abnormal circulating progesterone level [HP:0031212] <3>(1|1) (1|0|0)
- 1:   Abnormal thyroid hormone level [HP:0031508] <3>(0|0) (0|0|0)
- 1:   Abnormal adiponectin level [HP:0030684] <2>(0|0) (0|0|0)
- 1:   Abnormal antimullerian hormone level [HP:0031101] <2>(0|0) (0|0|0)
- 1:   Abnormal circulating osteocalcin level [HP:0031427] <2>(0|0) (0|0|0)
- 1:   Abnormal glucagon level [HP:0030687] <2>(0|0) (0|0|0)
- 1:   Abnormal growth hormone level [HP:0032367] <2>(1|1) (1|0|0)
- 1:   Abnormal pituitary glycoprotein hormone alpha subunit level [HP:0032481] <2>(0|0) (0|0|0)
- 1:   Abnormal serum insulin-like growth factor 1 level [HP:0030352] <2>(0|0) (0|0|0)
- 1:   Abnormality of circulating adrenocorticotropin level [HP:0011043] <2>(2|2) (2|0|0)
- 1:   Abnormality of circulating glucocorticoid level [HP:0012111] <2>(0|0) (1|0|0)
- 1:   Abnormality of circulating leptin level [HP:0004361] <2>(0|0) (0|0|0)
- 1:   Abnormality of gonadotropin-releasing hormone level [HP:0500012] <2>(0|0) (0|0|0)
- 1:   Abnormal circulating gastrin level [HP:0500166] <1>(0|0) (0|0|0)
- 1:   Abnormal circulating inhibin level [HP:0031099] <1>(0|0) (0|0|0)
- 1:   Abnormal insulin level [HP:0040214] <1>(0|0) (0|0|0)
- 1:   Abnormality of circulating catecholamine level [HP:0012099] <1>(0|0) (0|0|0)
- 1:   Abnormality of circulating pregnenolone level [HP:0031187](0|0) (0|0|0)
- 1:   Decreased circulating dehydroepiandrosterone level [HP:0031214](0|0) (0|0|0)
- 1:   Decreased circulating dehydroepiandrosterone-sulfate level [HP:0031215](0|0) (0|0|0)
- 1:   Elevated vascular endothelial growth factor level [HP:0031052](0|0) (0|0|0)
- 1:   Fasting hypoglycemia [HP:0003162](0|0) (0|0|0)
- 1:   Increased serum 1,25-dihydroxyvitamin D3 [HP:0003152](0|0) (0|0|0)
- 1:   Increased serum serotonin [HP:0003144](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nuclear receptor ligand-binding domain0.0005994Direct
NagB/RpiA/CoA transferase-like0.0579Inherited
Cytochrome P4500.07869Inherited
Homeodomain-like0.2076Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
IF2B-like0Direct
Acetylcholinesterase-like0.00008186Direct
PDEase0.0001632Direct
Nuclear receptor ligand-binding domain0.0003777Direct
GAF domain0.0006954Direct
Hypoxia-inducible factor Hif2a, C-terminal domain0.0006954Direct
Nuclear receptor0.0008683Direct
Cytochrome P4500.05805Inherited
Homeodomain0.1719Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nuclear receptor ligand-binding domain0.000315Direct
GAF domain-like0.0005921Direct
NagB/RpiA/CoA transferase-like0.04366Inherited
Cytochrome P4500.06078Inherited
Homeodomain-like0.175Inherited
Cystine-knot cytokines0.2542Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0004988Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.0005921Direct
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0005921Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.0005921Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.0005921Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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