SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Lactic acidosis

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Phenotypic abnormality [HP:0000118] <25>
+ + + + 4:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(76|83) (79|38|16)
+ + + 3:   Abnormal homeostasis [HP:0012337] <8>(42|43) (42|21|8)
+ + 2:   Abnormality of acid-base homeostasis [HP:0004360] <7>(19|15) (19|7|2)
+ 1:   Acidosis [HP:0001941] <8>(12|11) (12|5|2)
0:   Lactic acidosis [HP:0003128] <7>(2|2) (2|2|1)
- 1:   Chronic lactic acidosis [HP:0004925](0|0) (0|0|0)
- 1:   Congenital lactic acidosis [HP:0004902](0|0) (0|0|0)
- 1:   Exercise-induced lactic acidemia [HP:0004901](0|0) (0|0|0)
- 1:   Intermittent lactic acidemia [HP:0004913](0|0) (0|0|0)
- 1:   Persistent lactic acidosis [HP:0004898](0|0) (0|0|0)
- 1:   Severe lactic acidosis [HP:0004900](0|0) (0|0|0)
- 1:   Stress/infection-induced lactic acidosis [HP:0004897](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Thiamin diphosphate-binding fold (THDP-binding)0.0000002905Direct


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Branched-chain alpha-keto acid dehydrogenase Pyr module0.00001521Direct
Branched-chain alpha-keto acid dehydrogenase PP module0.00001521Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Thiamin diphosphate-binding fold (THDP-binding)0.0000001196Direct

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)