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Phenotypic Abnormality (PA): Abnormality of mitochondrial metabolism

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(75|82) (79|40|16)
+ + + 3:   Abnormal cellular phenotype [HP:0025354] <3>(10|10) (13|3|0)
+ + 2:   Abnormal cellular physiology [HP:0011017] <16>(10|10) (13|3|0)
+ 1:   Abnormality of the mitochondrion [HP:0012103] <2>(5|3) (7|1|0)
0:   Abnormality of mitochondrial metabolism [HP:0003287] <14>(5|3) (7|1|0)
- 1:   Abnormal activity of mitochondrial respiratory chain [HP:0011922] <2>(0|0) (0|0|0)
- 1:   Decreased plasma carnitine [HP:0003234] <2>(2|2) (2|1|0)
- 1:   3-Methylglutaconic aciduria [HP:0003535] <1>(0|0) (0|0|0)
- 1:   Abnormal iron deposition in mitochondria [HP:0008306](0|0) (0|0|0)
- 1:   Abnormal mitochondria in muscle tissue [HP:0008316](0|0) (0|0|0)
- 1:   Decreased activity of 3-hydroxyacyl-CoA dehydrogenase [HP:0100950](0|0) (0|0|0)
- 1:   Decreased activity of the pyruvate dehydrogenase complex [HP:0002928](0|0) (0|0|0)
- 1:   Deficiency or absence of cytochrome b(-245) [HP:0003514](0|0) (0|0|0)
- 1:   Electron transfer flavoprotein-ubiquinone oxidoreductase defect [HP:0003647](0|0) (0|0|0)
- 1:   Mitochondrial depletion [HP:0030059](0|0) (0|0|0)
- 1:   Mitochondrial lysine transport defect [HP:0008265](0|0) (0|0|0)
- 1:   Mitochondrial malic enzyme reduced [HP:0003232](0|0) (0|0|0)
- 1:   Mitochondrial propionyl-CoA carboxylase defect [HP:0003288](0|0) (0|0|0)
- 1:   Mitochondrial respiratory chain defects [HP:0200125](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Acyl-CoA dehydrogenase C-terminal domain-like0.000004691Direct
Acyl-CoA dehydrogenase NM domain-like0.000004691Direct
4Fe-4S ferredoxins0.00001544Direct
ClpP/crotonase0.0002091Direct
Adenine nucleotide alpha hydrolases-like0.000359Direct


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0000003674Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0000003674Direct
Crotonase-like0.00008135Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Acyl-CoA dehydrogenase NM domain-like0.00000193Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.00000193Direct
4Fe-4S ferredoxins0.000006619Direct
ClpP/crotonase0.0001007Direct
Adenine nucleotide alpha hydrolases-like0.0001782Direct
CoA-dependent acyltransferases0.0005481Direct
S-adenosyl-L-methionine-dependent methyltransferases0.0009927Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.00000193Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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