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Phenotypic Abnormality (PA): Abnormality of connective tissue

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of connective tissue [HP:0003549] <12>(19|27) (19|20|20)
- 1:   Abnormal adipose tissue morphology [HP:0009124] <10>(5|6) (5|1|2)
- 1:   Flexion contracture [HP:0001371] <9>(8|10) (8|7|1)
- 1:   Hernia [HP:0100790] <4>(5|7) (5|5|7)
- 1:   Scarring [HP:0100699] <4>(1|2) (1|1|2)
- 1:   Abnormality of odontoid tissue [HP:3000050] <3>(0|1) (0|1|0)
- 1:   Abnormal Sharpey fiber morphology [HP:0100685] <2>(0|0) (0|0|0)
- 1:   Abnormality of the fascia [HP:0100536] <1>(0|0) (0|0|0)
- 1:   Connective tissue nevi [HP:0100898] <1>(0|0) (0|0|0)
- 1:   Increased connective tissue [HP:0009025] <1>(0|0) (0|0|0)
- 1:   Cellulitis [HP:0100658](2|2) (2|0|0)
- 1:   Congenital mesoblastic nephroma [HP:0100881](0|0) (0|0|0)
- 1:   Musculotendinous retraction [HP:0031462](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Troponin coil-coiled subunits0Direct
CalX-like0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Smc hinge domain0Direct
Ribonuclease PH domain 2-like0Direct
Tropomyosin0.0007411Direct
Myosin rod fragments0.00953Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0196Inherited
Ribosomal protein S5 domain 2-like0.02353Inherited
Calponin-homology domain, CH-domain0.02992Inherited
Ribonuclease H-like0.05586Inherited
FnI-like domain0.1125Inherited
vWA-like0.1225Inherited
SH2 domain0.1259Inherited
Spectrin repeat0.1478Inherited
MIR domain0.2312Inherited
HMG-box0.2324Inherited
SH3-domain0.2938Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
CalX-beta domain0Direct
Proteasome subunits0Direct
Glycosyl transferases group 10Direct
Troponin T0Direct
Notch domain0Direct
Smc hinge domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Ribonuclease PH domain 1-like0Direct
Ribonuclease PH domain 2-like0Direct
Tropomyosin0.0004219Direct
Laminin-type module0.00279Inherited
Myosin rod fragments0.006395Inherited
DNA gyrase/MutL, second domain0.01018Inherited
DNA gyrase/MutL, N-terminal domain0.01018Inherited
Growth factor receptor domain0.01024Inherited
VWC domain0.01385Inherited
EGF-type module0.02187Inherited
Calponin-homology domain, CH-domain0.02196Inherited
LIM domain0.0262Inherited
Histone lysine methyltransferases0.02948Inherited
Integrin A (or I) domain0.04581Inherited
SH2 domain0.1049Inherited
Spectrin repeat0.1242Inherited
MIR domain0.2002Inherited
HMG-box0.2025Inherited
SH3-domain0.3235Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
Troponin coil-coiled subunits0Direct
CalX-like0Direct
Notch domain0Direct
Ribonuclease PH domain 2-like0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Tropomyosin0.0003847Direct
Myosin rod fragments0.006115Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01329Inherited
Ribosomal protein S5 domain 2-like0.01622Inherited
Calponin-homology domain, CH-domain0.02098Inherited
Ribonuclease H-like0.04162Inherited
FnI-like domain0.08894Inherited
vWA-like0.0979Inherited
SH2 domain0.1009Inherited
Spectrin repeat0.1206Inherited
MIR domain0.1958Inherited
HMG-box0.197Inherited
SH3-domain0.2542Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001477Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.009791Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.01329Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02207Inherited
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.02609Inherited
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.02609Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.06291Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.07056Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.129Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1958Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.005377Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01355Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02098Inherited
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.02609Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.02609Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.02609Inherited
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.02609Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.03092Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.04162Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)