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Phenotypic Abnormality (PA): Abnormal circulating carboxylic acid concentration

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(76|83) (79|38|16)
+ 1:   Abnormal circulating metabolite concentration [HP:0032180] <12>(29|32) (30|14|4)
0:   Abnormal circulating carboxylic acid concentration [HP:0004354] <6>(9|7) (9|4|1)
- 1:   Abnormality of serum amino acid level [HP:0003112] <17>(8|6) (8|3|1)
- 1:   Abnormal circulating dicarboxylic acid concentration [HP:0010995] <4>(0|0) (0|0|0)
- 1:   Abnormal circulating monocarboxylic acid cocentration [HP:0010996] <3>(0|0) (0|0|0)
- 1:   Elevated circulating gamma-aminobutyric acid concentration [HP:0032529](0|0) (0|0|0)
- 1:   Increased level of galactonate in red blood cells [HP:0410063](0|0) (0|0|0)
- 1:   Increased level of hippuric acid in blood [HP:0410065](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Aminomethyltransferase beta-barrel domain0Direct
Single hybrid motif0.00003259Direct
Folate-binding domain0.00003355Direct
Rudiment single hybrid motif0.00003355Direct
Glutathione synthetase ATP-binding domain-like0.0001931Direct
Thiamin diphosphate-binding fold (THDP-binding)0.0007361Direct
PreATP-grasp domain0.001038Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.004903Inherited
PLP-dependent transferases0.005378Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Aminomethyltransferase beta-barrel domain0Direct
BC C-terminal domain-like0.00002505Direct
Aminomethyltransferase folate-binding domain0.00002505Direct
Biotinyl/lipoyl-carrier proteins and domains0.00002921Direct
FAD-linked reductases, N-terminal domain0.0002827Direct
BC ATP-binding domain-like0.0008559Direct
BC N-terminal domain-like0.0008559Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Aminomethyltransferase beta-barrel domain0Direct
Single hybrid motif0.000015Direct
Folate-binding domain0.00001546Direct
Rudiment single hybrid motif0.00001546Direct
Glutathione synthetase ATP-binding domain-like0.00009558Direct
Thiamin diphosphate-binding fold (THDP-binding)0.0003917Direct
PreATP-grasp domain0.0005693Direct
Formate/glycerate dehydrogenase catalytic domain-like0.00302Inherited
PLP-dependent transferases0.003342Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
103025,101790
  • 103025 - Folate-binding domain
  • 101790 - Aminomethyltransferase beta-barrel domain
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.00001546Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.0005693Direct
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.0007077Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.00001546Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)