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Phenotypic Abnormality (PA): Abnormality of temperature regulation

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(75|82) (79|40|16)
+ 1:   Abnormal homeostasis [HP:0012337] <8>(44|47) (44|22|8)
0:   Abnormality of temperature regulation [HP:0004370] <6>(10|13) (10|6|2)
- 1:   Fever [HP:0001945] <4>(5|9) (5|4|2)
- 1:   Hypothermia [HP:0002045] <1>(2|2) (2|1|0)
- 1:   Heat intolerance [HP:0002046](0|0) (0|0|0)
- 1:   Impaired thermal sensitivity [HP:0006901](0|0) (0|0|0)
- 1:   Malignant hyperthermia [HP:0002047](2|2) (2|1|0)
- 1:   Temperature instability [HP:0005968](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DEATH domain0.0000001414Direct
RNI-like0.007722Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01207Inherited
SH2 domain0.01311Inherited
Transcription factor STAT-4 N-domain0.01389Inherited
STAT0.01389Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1733Inherited
Nicotinic receptor ligand binding domain-like0.1733Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1836Inherited
Acyl-CoA dehydrogenase NM domain-like0.1836Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
IF2B-like0Direct
Pyrin domain, PYD0.00005606Direct
Caspase recruitment domain, CARD0.001936Inherited
28-residue LRR0.003154Inherited
SH2 domain0.008261Inherited
Transcription factor STAT-4 N-domain0.009053Inherited
STAT DNA-binding domain0.009053Inherited
STAT0.009053Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1502Inherited
Nicotinic receptor ligand binding domain-like0.1502Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.1509Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.1509Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DEATH domain0.00000005484Direct
RNI-like0.004875Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.007876Inherited
SH2 domain0.008627Inherited
Transcription factor STAT-4 N-domain0.009183Inherited
STAT0.009183Inherited
Nicotinic receptor ligand binding domain-like0.1428Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1428Inherited
Acyl-CoA dehydrogenase NM domain-like0.152Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.152Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00004585Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.009183Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.009183Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.009183Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.1428Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.152Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.009183Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.009183Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)