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Phenotypic Abnormality (PA): Abnormality of complement system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the immune system [HP:0002715] <3>(37|52) (39|28|15)
+ + 2:   Abnormality of immune system physiology [HP:0010978] <14>(29|40) (31|23|11)
+ 1:   Abnormality of humoral immunity [HP:0005368] <4>(13|16) (13|9|5)
0:   Abnormality of complement system [HP:0005339] <4>(10|10) (10|7|5)
- 1:   Complement deficiency [HP:0004431] <8>(6|6) (6|2|1)
- 1:   Abnormal total hemolytic complement activity [HP:0031904] <2>(0|0) (0|0|0)
- 1:   Abnormality of the alternative complement pathway [HP:0005482] <2>(0|0) (0|0|0)
- 1:   Reduced hemolytic complement activity [HP:0025434](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Alpha-macroglobulin receptor domain0.00000007285Direct
TIMP-like0.0000001611Direct
Complement control module/SCR domain0.000006381Direct
LDL receptor-like module0.00003059Direct
TSP-1 type 1 repeat0.00003794Direct
Spermadhesin, CUB domain0.0001398Direct
Trypsin-like serine proteases0.0002186Direct
Terpenoid cyclases/Protein prenyltransferases0.001147Inherited
TNF-like0.07746Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Netrin-like domain (NTR/C345C module)0Direct
Alpha-macroglobulin receptor domain0.0000000712Direct
Complement components0.0000000712Direct
Complement control module/SCR domain0.00001057Direct
LDL receptor-like module0.00003048Direct
TSP-1 type 1 repeat0.00004598Direct
Spermadhesin, CUB domain0.0001256Direct
Eukaryotic proteases0.0002639Direct
TNF-like0.08361Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Alpha-macroglobulin receptor domain0.00000002973Direct
TIMP-like0.00000006611Direct
Complement control module/SCR domain0.000002783Direct
LDL receptor-like module0.00001404Direct
TSP-1 type 1 repeat0.00001754Direct
Spermadhesin, CUB domain0.00006796Direct
Trypsin-like serine proteases0.0001092Direct
Terpenoid cyclases/Protein prenyltransferases0.0006301Direct
TNF-like0.05979Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
82895,57424
  • 82895 - TSP-1 type 1 repeat
  • 57424 - LDL receptor-like module
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.00000006695Direct
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.00000006695Direct
    49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0.0000003252Direct
    57196,49854
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.0000009486Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.000002783Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.00000006695Direct
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.00000006695Direct
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.00000006695Direct
    49854,57196,49854
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.0000003252Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.002599Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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