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Phenotypic Abnormality (PA): Abnormality of humoral immunity

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the immune system [HP:0002715] <3>(37|52) (39|28|15)
+ 1:   Abnormality of immune system physiology [HP:0010978] <14>(29|40) (31|23|11)
0:   Abnormality of humoral immunity [HP:0005368] <4>(13|16) (13|9|5)
- 1:   Abnormal immunoglobulin level [HP:0010701] <8>(3|6) (3|2|0)
- 1:   Abnormality of complement system [HP:0005339] <4>(10|10) (10|7|5)
- 1:   Circulating immune complexes [HP:0012224](0|0) (0|0|0)
- 1:   Cryoglobulinemia [HP:0100778](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Complement control module/SCR domain0.000001313Direct
SH2 domain0.0001586Direct
TNF-like0.0003227Direct
TSP-1 type 1 repeat0.0003302Direct
TNF receptor-like0.0003302Direct
Terpenoid cyclases/Protein prenyltransferases0.0009896Direct
TIMP-like0.003664Inherited
Alpha-macroglobulin receptor domain0.003664Inherited
Trypsin-like serine proteases0.00675Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01286Inherited
LDL receptor-like module0.0439Inherited
Spermadhesin, CUB domain0.0448Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
Anaphylotoxins (complement system)0Direct
Netrin-like domain (NTR/C345C module)0Direct
Complement control module/SCR domain0.0000006638Direct
SH2 domain0.00008759Direct
TNF-like0.0001806Direct
TSP-1 type 1 repeat0.0001851Direct
Alpha-macroglobulin receptor domain0.002283Inherited
Complement components0.002283Inherited
Eukaryotic proteases0.002435Inherited
TNF receptor-like0.002526Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.02638Inherited
LDL receptor-like module0.03437Inherited
Spermadhesin, CUB domain0.03485Inherited
DEATH domain, DD0.03856Inherited
C1 set domains (antibody constant domain-like)0.05624Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Complement control module/SCR domain0.0000005532Direct
SH2 domain0.00007743Direct
TNF-like0.0001641Direct
TNF receptor-like0.0001684Direct
TSP-1 type 1 repeat0.0001684Direct
Terpenoid cyclases/Protein prenyltransferases0.0005394Direct
Alpha-macroglobulin receptor domain0.002201Inherited
TIMP-like0.002201Inherited
Trypsin-like serine proteases0.004286Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.008559Inherited
LDL receptor-like module0.03219Inherited
Spermadhesin, CUB domain0.03294Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
82895,57424
  • 82895 - TSP-1 type 1 repeat
  • 57424 - LDL receptor-like module
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0000005532Direct
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.0001199Direct
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.0001199Direct
    49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0.0004983Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0006682Direct
    57196,49854
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.00124Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.008356Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.0001199Direct
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0001199Direct
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.0001199Direct
    49854,57196,49854
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.0004983Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.002061Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)