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Phenotypic Abnormality (PA): Abnormality of B cell physiology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of metabolism/homeostasis [HP:0001939] <16>(75|82) (79|40|16)
+ + + 3:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
+ + + 3:   Abnormal cellular phenotype [HP:0025354] <3>(10|10) (13|3|0)
+ + 2:   Abnormality of immune system physiology [HP:0010978] <14>(29|37) (31|22|11)
+ + 2:   Abnormal cellular physiology [HP:0011017] <16>(10|10) (13|3|0)
+ 1:   Abnormal lymphocyte physiology [HP:0031409] <5>(5|6) (5|2|0)
0:   Abnormality of B cell physiology [HP:0005372] <5>(5|6) (5|2|0)
- 1:   Abnormal immunoglobulin level [HP:0010701] <8>(3|5) (3|2|0)
- 1:   Defective B cell activation [HP:0005384] <1>(0|0) (0|0|0)
- 1:   Absent specific antibody response [HP:0005424](0|0) (0|0|0)
- 1:   Impaired Ig class switch recombination [HP:0002959](0|0) (0|0|0)
- 1:   Impaired memory B cell generation [HP:0002847](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DEATH domain0.000001429Direct
TNF receptor-like0.000001689Direct
SH2 domain0.000009377Direct
TNF-like0.001106Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.003055Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
SH2 domain0.000004827Direct
TNF receptor-like0.00009097Direct
DEATH domain, DD0.0004266Direct
C1 set domains (antibody constant domain-like)0.0004266Direct
TNF-like0.0006464Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DEATH domain0.0000005717Direct
TNF receptor-like0.000000679Direct
SH2 domain0.000003931Direct
TNF-like0.0005908Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.001774Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000001352Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0003855Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)