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Phenotypic Abnormality (PA): Atrophy/Degeneration affecting the central nervous system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ + 2:   Abnormality of nervous system morphology [HP:0012639] <5>(69|97) (79|52|16)
+ 1:   Morphological abnormality of the central nervous system [HP:0002011] <17>(60|85) (69|44|16)
0:   Atrophy/Degeneration affecting the central nervous system [HP:0007367] <10>(3|5) (5|3|0)
- 1:   Brain atrophy [HP:0012444] <3>(1|3) (3|2|0)
- 1:   Atrophy/Degeneration involving the corticospinal tracts [HP:0007372] <2>(0|0) (0|0|0)
- 1:   Increased cerebral lipofuscin [HP:0011813] <2>(0|0) (0|0|0)
- 1:   Motor neuron atrophy [HP:0007373] <2>(2|2) (2|1|0)
- 1:   Atrophy/Degeneration involving the spinal cord [HP:0007344] <1>(0|0) (0|0|0)
- 1:   Neurodegeneration [HP:0002180] <1>(1|1) (2|0|0)
- 1:   Senile plaques [HP:0100256] <1>(0|0) (0|0|0)
- 1:   Atrophy/Degeneration affecting the brainstem [HP:0007366](0|0) (0|0|0)
- 1:   Central nervous system degeneration [HP:0007009](0|0) (0|0|0)
- 1:   Neuronal loss in central nervous system [HP:0002529](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Calcium-dependent phosphotriesterase0.006769Inherited
RNA-binding domain, RBD0.04696Inherited
Actin-like ATPase domain0.05355Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Serum paraoxonase/arylesterase 1, PON10Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.007682Inherited
Clathrin adaptor core protein0.01157Inherited
Canonical RBD0.01351Inherited
PDZ domain0.124Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Calcium-dependent phosphotriesterase0.004235Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.0204Inherited
RNA-binding domain, RBD0.03433Inherited
PDZ domain-like0.03477Inherited
Actin-like ATPase domain0.03975Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.005357Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.07466Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.1539Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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